Organochlorine Pesticides in Placentas from Southern Spain and Some Related Factors

Lopez-Espinosa, Maria-José; Granada, Alicia; Carreño, Johanny; Salvatierra, Maite; Olea‐Serrano, F.; Olea, Nicolás

doi:10.1016/j.placenta.2006.09.009

Cited by 99 publications

(41 citation statements)

References 52 publications

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“…Humans may be exposed to mixtures of these and numerous other compounds, hampering the prediction of effects on TH levels. We have previously demonstrated the ubiquity of exposure to OC xeno-oestrogens in the INMA-Granada cohort (54). In this study, prenatal exposure to 17 OC pesticides or the xeno-oestrogenic burden in the placentas were observed to modify the impact of neonatal TSH on neurodevelopment, in agreement with the suspected capacity of OCs to interfere with the thyroid system (20)(21)(22)(23)(24)(25)(26).…”

Section: Discussionsupporting

confidence: 85%

Newborn TSH concentration and its association with cognitive development in healthy boys

Freire

Ramos²,

Amaya³

et al. 2010

European Journal of Endocrinology

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Objective: An association between thyroid function during pregnancy or infancy and neurodevelopment in children has been demonstrated. We aimed to investigate whether newborn TSH concentrations are related to subsequent neurocognitive development. Design: We conducted a longitudinal study on 178 children from a general population birth cohort in Granada (Spain) born in [2000][2001][2002]. Methods: TSH concentrations were measured in umbilical cord blood, and cognitive functions were assessed at 4 years of age using the McCarthy's scales of children's abilities (MSCA). Organochlorine (OC) compound concentrations and the combined oestrogenicity (total effective xeno-oestrogenic burden (TEXB)) were also determined in the placentae. Results: Mean newborn TSH was 3.55 mU/l (rangeZ0.24-17 mU/l). In multivariate regression analyses, adjusting for maternal and child characteristics, higher newborn TSH concentrations showed a decrease of 3.51 and 3.15 points on the MSCA general cognitive and executive function scores respectively and were associated with a higher risk of scoring below the 20th percentile (P20) on the quantitative score (odds ratio (OR)Z2.64). Children with TSH in the upper quartile (4.19-17.0 mU/l) were at higher risk of scoring !P20 on span memory (ORZ5.73), whereas children with TSH in the second quartile (2.05-2.95 mU/l) were at lower risk of scoring !P20 on the verbal scale (ORZ0.24). Neonatal TSH status was also associated with general cognitive and executive function outcomes when controlling for prenatal exposure to OCs or placental TEXB. Conclusions: Newborn thyroid hormone status expressed by TSH in cord blood may adversely affect later cognitive function. A more thorough screening for neonatal thyroid deficiency is warranted.

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Section: Discussionsupporting

confidence: 85%

Newborn TSH concentration and its association with cognitive development in healthy boys

Freire

Ramos²,

Amaya³

et al. 2010

European Journal of Endocrinology

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“…In utero exposure to p-p DDT and o-p DDT was also found to be associated with deleterious mental development [13]. Recently, in a study performed to mothers living in Southern Spain, a larger number of OC pesticide residues in placenta were significantly associated with lower birth weight, confirming previous observations [9].…”

Section: Introductionsupporting

confidence: 64%

“…Organochlorine pesticides have been detected in human body fluids and tissues including placenta [7][8][9]. Exploring the adverse effect of chemicals during pregnancy is very important because of the vulnerability of this particular period of human development [10].…”

Section: Introductionmentioning

confidence: 99%

Heptachlor and o‐p′DDT effects on protein kinase activities associated with human placenta particulate fractions

Magnarelli

Souza

D’Angelo

2009

J Biochem & Molecular Tox

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Organochlorine pesticides have been detected in placenta. The ability of heptachlor (HC) and 1,1,1-tricholoro-2-(2-chlorophenyl)-2-4-chlorophenyl)ethane (o-p'DDT) to interfere with protein phosphorylation was evaluated. In vitro incubations of cell-free placental villi homogenates with a concentration range 1-100 microM were performed. In particulate fractions, total serine/threonine kinase activity was increased by 10 microM HC and o-p' DDT (59% and 82%, respectively). Maximum eightfold increase was observed with 10 microM o-p' DDT on protein kinase A activity. By contrast, protein kinase C activity was reduced by 10 microM HC and o-p' DDT (40% and 52%, respectively). Endogenous substrate phosphorylation studies demonstrated that slight but significant increase in 24-kDa band labeling was produced in nuclear samples with 1, 10, and 100 microM HC and 100 microM o-p' DDT. Exposition to 100 microM HC increased 85-kDa band labeling. In mitochondrial fractions, 10 microM HC and o-p' DDT increased 24- and 65-kDa bands' labeling. These data indicate that both pesticides affect protein kinase activities in particulate fraction. Nuclear compartmentalization of these compounds, insertion in membranes, and chemical stress production may be associated to the observed effects, thus suggesting deleterious consequences in signaling pathways.

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“…For instance, aldrin is still observed in human breast milk from developing countries (Yalcin et al, 2014) or in placenta of pregnant women from Southern Spain, (Lopez-Espinosa et al, 2007) meaning that these contaminants accumulate in body fats, which may have potential impact on human health. On the other hand, CPF is not a lipophilic compound but is a currently used pesticide in more than 80 countries, whose residues can be found in fruits and vegetables (Angioni et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Phenotypic malignant changes and untargeted lipidomic analysis of long-term exposed prostate cancer cells to endocrine disruptors

Bedia

Dalmau

Jaumot

et al. 2015

Environmental Research

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Endocrine disruptors (EDs) are a class of environmental toxic molecules able to interfere with the normal hormone metabolism. Numerous studies involve EDs exposure to initiation and development of cancers, including prostate cancer. In this work, three different EDs (aldrin, aroclor 1254 and chlorpyrifos (CPF)) were investigated as potential inducers of a malignant phenotype in DU145 prostate cancer cells after a chronic exposure. Epithelial to mesenchymal transition (EMT) induction, proliferation, migration, colony formation and release of metalloproteinase 2 (MMP-2) were analyzed in 50-day exposed cells to the selected EDs. As a result, aldrin and CPF exposure led to an EMT induction (loss of 16% and 14% of E-cadherin levels, respectively, compared to the unexposed cells). Aroclor and CPF presented an increased migration (134% and 126%, respectively), colony formation (204% and 144%, respectively) and MMP-2 release (137% in both cases) compared to the unexposed cells. An untargeted lipidomic analysis was performed to decipher the lipids involved in the observed transformations. As general results, aldrin exposure showed a global decrease in phospholipids and sphingolipids, and aroclor and CPF showed an increase of certain phospholipids, glycosphingolipids as well as a remarkable increase of some cardiolipin species. Furthermore, the three exposures resulted in an increase of some triglyceride species. In conclusion, some significant changes in lipids were identified and thus we postulate that some lipid compounds and lipid metabolic pathways could be involved in the acquisition of the malignant phenotype in exposed prostate cancer cells to the selected EDs.

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Organochlorine Pesticides in Placentas from Southern Spain and Some Related Factors

Cited by 99 publications

References 52 publications

Newborn TSH concentration and its association with cognitive development in healthy boys

Newborn TSH concentration and its association with cognitive development in healthy boys

Heptachlor and o‐p′DDT effects on protein kinase activities associated with human placenta particulate fractions

Phenotypic malignant changes and untargeted lipidomic analysis of long-term exposed prostate cancer cells to endocrine disruptors

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