Organogel investigations as a floating oral system with depot property

Kaddoori, Zainab Saad; Mohamed, Masar Basim Mohsin; Numan, None Nawfal Am.

doi:10.32947/ajps.v20i4.783

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…Sodium bicarbonate was used as gas generating or foaming agent. The required amount of each ingredient is demonstrated in table (1). First, the required amount of PVA was weighed and placed in a glass test tube of (10 ml in volume).…”

Section: Super Porous Hydrogel Composite Preparationmentioning

confidence: 99%

“…A gastroretentive drug delivery system (GRDDS) is an approach widely used and investigated in oral drug delivery to maintain the medication in the stomach for an extended period of time (1). It is specifically advantageous for drugs with narrow absorption windows, drugs that are highly absorbed from the stomach, or drugs intended for local gastric effect (2).…”

Section: Introductionmentioning

confidence: 99%

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Effect of modification of formulation variables on physical characterization of superporouse hydrogel

Safa Mohammed Nser,

Athmar Dhahir Habeeb Al-Shohani

2023

AJPS

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Superporouse hydrogel (SPH) is widely used and investigated as a gastro retentive drug delivery system to extend drug residence time in the stomach However, their mechanical strength represents a problem because they need to withstand the peristaltic movement of the stomach. Properties of SPH are widely affected by the materials used for their synthesis. The aim of the research is to study the effect of changing the foaming agent and foam stabilizer amount on physical properties, in particular mechanical strength, and drug release from SPH. Trifluoperazine HCl will be used as model drug in the study. SPH formulations was prepared using fixed amount of acrylamide (AM) and polyvinyl alcohol (PVA) as monomers, polyethylene glycol diacrylate (PEGDA) as cross-linker, TRFP as model drug and variable amount of sodium bicarbonate (NaHCO3) as foaming agent, and tween 20 as foam stabilizer. Ammonium persulphate (APS) / tetramethyl ethylenediamine (TEMED) system was used as polymerization initiator. The effect of changing foaming agent and foam stabilizer on mechanical strength, buoyancy, porosity, density, drug release, drug content, swelling ratio, and swelling time was investigated. Modifying both factors affected all the physical properties and drug release profile. When tween 20 was increased the mechanical strength, density and floating lag time was increased with a reduction in porosity and drug release. While increasing NaHCO3 reduced mechanical strength, density and floating lag time with increased porosity and faster drug release was observed. Optimum physical properties were observed in formula 2 which had 230 µl of Tween 20 (v/v) and 50 mg of NaHCO3 in which the mechanical strength was 579±0.4, floating lag time 14 min and 80% of the drug was released within 12 hr. As a conclusion SPH with improved mechanical strength, physical properties and drug release pattern can be achieved by changing foam stabilizer and foaming agent amount in the formulations.

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Section: Super Porous Hydrogel Composite Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of modification of formulation variables on physical characterization of superporouse hydrogel

Safa Mohammed Nser,

Athmar Dhahir Habeeb Al-Shohani

2023

AJPS

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Tailoring and Optimization of Nifedipine Controlled Release Organogel via Quality by Design Approach

Dave,

Kariya,

Dudhat

2024

J Pharm Innov

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Effect Of Different Variables On The Formulation Of Sodium Alginate Beads

Lateef,

Basim,

Mohammed

2024

AJPS

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This work examined the possibility of encapsulating prednisolone as drug modelling in Na-alginate polymeric beads. Our beads were formulated by ionotropic gelation method using Na-alginate as an anionic natural polysaccharide polymer and Cacl2 as a positive charge cross-linker. Eleven formulations were successfully created, and different variations were evaluated, including Na-alginate concentration ( 0.5, 2, 3) w/v %, Cacl2 concentration (1, 3, 5) w/v % stirring speed (100, 300, 400) rpm, the addition of tween-80 (0, 2.5, 5) ml, washing beads with alcohol, change curing time. The beads were assayed by bead size, morphology, drug loading, encapsulation efficiency, yield and FTIR. The results showed that the best formula was F2 which can be obtained when using a high concentration of Na-alginate (2 w/v %), Cacl2 (5 w/v %), the addition of tween-80 (5ml) with the lowest stirring speed (100 rpm) without increase curing time or washing with alcohol. Also, the FTIR result revealed a shifting of the carbonyl group and a low intensity of the hydroxyl group in the spectrogram of F2, indicating potential hydrogen bond interactions that might have resulted in the creation of beads.

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Organogel investigations as a floating oral system with depot property

Cited by 4 publications

References 27 publications

Effect of modification of formulation variables on physical characterization of superporouse hydrogel

Effect of modification of formulation variables on physical characterization of superporouse hydrogel

Tailoring and Optimization of Nifedipine Controlled Release Organogel via Quality by Design Approach

Effect Of Different Variables On The Formulation Of Sodium Alginate Beads

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