Organoids as regenerative medicine for inflammatory bowel disease

Hammerhøj, Alexander; Chakravarti, Deepavali; Sato, Toshiro; Jensen, Kim Bak; Nielsen, Ole Haagen

doi:10.1016/j.isci.2024.110118

iScience

2024

DOI: 10.1016/j.isci.2024.110118

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Organoids as regenerative medicine for inflammatory bowel disease

Alexander Hammerhøj,

Deepavali Chakravarti,

Toshiro Sato

et al.

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2024

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Cited by 3 publications

References 113 publications

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Establishment of an ulcerative colitis model using colon organoids derived from human induced pluripotent stem cells

Yokoi,

Deguchi,

Watanabe

et al. 2024

iScience

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Establishment of an ulcerative colitis model using colon organoids derived from human induced pluripotent stem cells

Yokoi,

Deguchi,

Watanabe

et al. 2024

iScience

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Dissecting Innate and Adaptive Immunity in Inflammatory Bowel Disease: Immune Compartmentalization, Microbiota Crosstalk, and Emerging Therapies

Yue,

Hu,

Tian

et al. 2024

JIR

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The intestinal immune system is the largest immune organ in the human body. Excessive immune response to intestinal cavity induced by harmful stimuli including pathogens, foreign substances and food antigens is an important cause of inflammatory diseases such as celiac disease and inflammatory bowel disease (IBD). Although great progress has been made in the treatment of IBD by some immune-related biotherapeutic products, yet a considerable proportion of IBD patients remain unresponsive or immune tolerant to immunotherapeutic strategy. Therefore, it is necessary to further understand the mechanism of immune cell populations involved in enteritis, including dendritic cells, macrophages and natural lymphocytes, in the steady-state immune tolerance of IBD, in order to find effective IBD therapy. In this review, we discussed the important role of innate and adaptive immunity in the development of IBD. And the relationship between intestinal immune system disorders and microflora crosstalk were also presented. We also focus on the new findings in the field of T cell immunity, which might identify novel cytokines, chemokines or anti-cytokine antibodies as new approaches for the treatment of IBD.

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Advances in the research of intestinal fungi in Crohn's disease

Kong,

Yu,

Wang

et al. 2024

World J Gastroenterol

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This article reviews of the original research published by Wu et al in the World Journal of Gastroenterology , delving into the pivotal role of the gut microbiota in the pathogenesis of Crohn's disease (CD). Insights were gained from fecal microbiota transplantation (FMT) in mouse models, revealing the intricate interplay between the gut microbiota, mesenteric adipose tissue (MAT), and creeping fat. The study uncovered the characteristics of inflammation and fibrosis in the MAT and intestinal tissues of patients with CD; moreover, through the FMT mouse model, it observed the impact of samples from healthy patients and those with CD on symptoms. The pathogenesis of CD is complex, and its etiology remains unclear; however, it is widely believed that gut microbiota dysbiosis plays a significant role. Recently, with the development and application of next-generation sequencing technology, research on the role of fungi in the pathogenesis and chronicity of CD has deepened. This editorial serves as a supplement to the research by Wu et al who discussed advances related to the study of fungi in CD.

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Organoids as regenerative medicine for inflammatory bowel disease

Cited by 3 publications

References 113 publications

Establishment of an ulcerative colitis model using colon organoids derived from human induced pluripotent stem cells

Establishment of an ulcerative colitis model using colon organoids derived from human induced pluripotent stem cells

Dissecting Innate and Adaptive Immunity in Inflammatory Bowel Disease: Immune Compartmentalization, Microbiota Crosstalk, and Emerging Therapies

Advances in the research of intestinal fungi in Crohn's disease

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