2010
DOI: 10.1016/j.jbiosc.2010.01.010
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Organomercurials removal by heterogeneous merB genes harboring bacterial strains

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Cited by 46 publications
(27 citation statements)
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“…The processed products by organomercury lyase are finally volatilized by MerA gene. The merB gene is considered as an ancillary component of the mer operon (Mei-Fang Chien et al 2010). In most cases, merB gene was found to be mapped immediately downstream of merA gene.…”
Section: Role Of Merb Gene In Organomercurial Mercury Volatilizationmentioning
confidence: 99%
“…The processed products by organomercury lyase are finally volatilized by MerA gene. The merB gene is considered as an ancillary component of the mer operon (Mei-Fang Chien et al 2010). In most cases, merB gene was found to be mapped immediately downstream of merA gene.…”
Section: Role Of Merb Gene In Organomercurial Mercury Volatilizationmentioning
confidence: 99%
“…Interestingly, the serine-containing MerB2 protein from Bacillus megaterium is considerably less efficient at cleaving carbon–Hg bonds relative to its MerB1 protein, which has an aspartic acid residue in the active site. 4749 Finally, substituting serine in place of D99 in E. coli MerB results in a mutant protein that sequesters Cu II when expressed in bacteria and has significantly lower catalytic activity. 50 Taken together with our current results on organotin and organolead compounds, initial binding to D99 is important not only for the catalytic activity of MerB, but also for metal selectivity.…”
Section: Discussionmentioning
confidence: 99%
“…Further, metabolic analyses can be used as diagnostic tools in the study of microbial cell status and environmental conditions. From the perspective of a synthetic biologist, engineering microbial metabolomics has direct links with applications: to degrade toxins (Dziga et al, 2012), herbicides (Sinha et al, 2010), and environmental pollutants (Chien et al, 2010), and to produce chemicals (Curran and Alper, 2012), pharmaceuticals (Paddon et al, 2013), and biofuels (Zhang et al, 2011; Peralta-Yahya et al, 2012). …”
Section: Metabolomicsmentioning
confidence: 99%