Organometallic Complexes as Enzyme Inhibitors: A Conceptual Overview

Organoruthenium(II) Complexes Bearing an Aromatase Inhibitor: Synthesis, Characterization, in Vitro Biological Activity and in Vivo Toxicity in Zebrafish Embryos

“…7,8 A number of anticancer metal complexes including an enzyme inhibitor in their structure have been reported previously. [9][10][11] However, metal complexes bearing aromatase inhibitors have so far been overlooked. Aromatase is the enzyme that catalyzes the final, rate-limiting step in estrogen synthesis from androgens.…”

“…In addition, metal complexation greatly increases the structural possibilities to form enzyme inhibitors relative to purely organic molecules. Because they can adopt geometries other than linear, trigonal, or tetrahedral, metals can allow organic ligands (or enzyme inhibitors) to occupy a specific position in the active site of enzymes. , A number of anticancer metal complexes including an enzyme inhibitor in their structure have been reported previously. − However, metal complexes bearing aromatase inhibitors have so far been overlooked. Aromatase is the enzyme that catalyzes the final, rate-limiting step in estrogen synthesis from androgens .…”