Organometallic complexes of transition metals in luminescent cell imaging applications

Thorp‐Greenwood, Flora L.; Balasingham, Rebeca; Coogan, Michael P.

doi:10.1016/j.jorganchem.2012.01.020

Cited by 136 publications

(82 citation statements)

References 60 publications

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“…This is generally done by tuning the structure of the N^N ligand, since it is involved in the MLCT. Two families of ligand have been particularly explored: (i) polypyridyl ligands, mostly derived from 2,2'-bipyridine (bpy) and 1,10-phenanthroline (phen) [19][20][21][23][24][25][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] and (ii) bis-quinoline and its derivatives, e.g. bis(phenanthridinylmethyl)amine (bpm) [22,[43][44][45].…”

Section: Spectroscopic Properties Of Luminescent Re(i) Tricarbonyl Comentioning

confidence: 99%

“…Indeed, their use for correlative fluorescence and infrared imaging was recently exemplified which demonstrates their validity as Single Core Multimodal Probes for Imaging (SCoMPIs) [10,[12][13][14]. Biological applications of Re(CO) 3 complexes based either on their luminescence or infrared properties have been extensively reviewed [15][16][17][18][19][20][21][22][23][24][25]. In the present review, after a brief overview on their applications and potential as probes or drugs relying on their photophysical properties, we will attempt to give a special focus on their use as multimodal probes for the labelling and imaging of peptides and proteins.…”

Section: Introductionmentioning

confidence: 99%

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Re(I) carbonyl complexes: Multimodal platforms for inorganic chemical biology

Hostachy

Policar

Delsuc

2017

Coordination Chemistry Reviews

113

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Bio-imaging, by enabling the visualization of biomolecules of interest, has proved to be highly informative in the study of biological processes. Although fluorescence microscopy is probably one of the most used techniques, alternative methods of imaging, providing complementary information, are emerging. In this context, metal complexes represent valuable platforms for multimodal imaging, since they may combine interesting spectroscopic features and biologically relevant functionalization on a single molecular core. In particular, d6 low-spin rhenium tri-carbonyl complexes display unique luminescence and vibrational properties, and can be readily functionalized. Here we review their applications and potential as probes or drugs relying on their photophysical properties, before focusing on their use as multimodal probes for the labelling and imaging of peptides and proteins.

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Section: Spectroscopic Properties Of Luminescent Re(i) Tricarbonyl Comentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Re(I) carbonyl complexes: Multimodal platforms for inorganic chemical biology

Hostachy

Policar

Delsuc

2017

Coordination Chemistry Reviews

113

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“…For instance, many Re organometallic complexes are excellent luminescent probes with long-lived emission states, large Stokes shifts, high quantum yields and emission that can be tuned by varying the ligands. 37,48 They can thus be easily followed inside cells by conventional and/or time-resolved (e.g. FLIMS) emission microscopy to elucidate their cellular distribution and mechanism of action.…”

Section: -14mentioning

confidence: 99%

Underestimated Potential of Organometallic Rhenium Complexes as Anticancer Agents

2014

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ABSTRACT:In the recent years, organometallic compounds have become recognized as promising anti-cancer drug candidates. While radioactive 186/188 Re compounds are already used in clinics for cancer treatment, cold Re organometallic compounds have mostly been explored as luminescent probes and photosensitizers in photo-catalysis. However, a growing number of studies have recently revealed the potential of Re organometallic complexes as anticancer agents.Several compounds have displayed cytotoxicity equaling or exceeding that of the well-established anti-cancer drug cisplatin. In this review, we present the currently known Re organometallic complexes that have shown anti-proliferative activity on cancer cell lines. A particular emphasis is placed on their cellular uptake and localization as well as their potential mechanism of action.

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“…Além dessas características, buscam-se compostos nos quais a geração de oxigênio singlete seja minimizada, uma vez que ele é responsável por causar morte celular e levar a total inutilização do sistema para obtenção de imagens. 29,[66][67][68] Já para obtenção de imagens celulares in vivo existe o problema da existência de componentes celulares que são capazes de absorver e emitir luz, como o grupo indol do triptofano comumente encontrado em proteínas. Para evitar interferências, os marcadores devem possuir emissão em comprimentos de onda distintos das biomoléculas, com tempo de vida de emissão que permita a sua diferenciação, além de possuir comprimentos de onda de excitação e emissão em regiões mais penetrantes nos tecidos.…”

Section: Fotossensores Biológicosunclassified

A importância do estado excitado 3MLCT de compostos de Ru(II), Re(I) e Ir(III) no desenvolvimento de fotossensores, OLEDS e fotorredução de CO2

Müller¹,

Gonçalves²,

Ramos³

et al. 2016

Quim. Nova

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. The photochemistry and photophysics of coordination compounds have been extensively investigated not only because their structure, stability, reactivity dependence on the metal center oxidation state and the coordinated ligand; but also for their electronic transitions in a wide range of visible radiation. The knowledge of light absorption, excited state deactivation, sensitization and quenching processes are crucial to their manipulation aiming the development of systems capable of execute useful functions such as photosensors and/or probes, luminescent devices and molecular systems to convert sunlight into other types of energy. In this review, the progresses and challenges of biomolecules photosensors, organic light emitting diodes and CO 2 photoreduction catalysts based on ruthenium(II), rhenium(I) or iridium(III) coordination compounds are discussed based on their photochemical and photophysical processes.Keywords: Coordination chemistry; inorganic photochemistry; biomolecules photosensors; organic light emitting diodes; CO 2 photocatalysts. INTRODUÇÃOO desenvolvimento e a compreensão de sistemas baseados em estruturas moleculares que utilizam fótons como reagente para a ocorrência de processos químicos e físicos é o foco da fotoquímica, ciência que vem adquirindo cada vez mais destaque, principalmente, devido às potenciais aplicações em processos de conversão de energia 1-8 ou em sistemas biológicos. 9-16Compostos de coordenação apresentam grande potencial para aplicações em sistemas fotoquímicos 17-26 devido à possibilidade de incorporar diferentes ligantes a centros metálicos para formar subunidades com funcionalidades específicas que podem estar relacionadas às suas transições eletrônicas. O processo fotoquímico, que se inicia com a absorção de luz por uma espécie química e resulta na transição de um elétron do estado fundamental para um estado excitado, pode ter seu mecanismo representado por um diagrama de Jablonski, Figura 2.28-30 Na transição eletrônica, um elétron do orbital molecular ocupado de mais alta energia (Highest Occupied Molecular Orbital, HOMO) passa a ocupar, no estado excitado, um orbital molecular não-ocupado, produzindo uma nova espécie química com características distintas daquelas do estado fundamental.31 Estas novas características permitem que reações que não são observadas em processos térmicos ocorram quando a espécie é exposta à luz.O estado excitado inicialmente populado, segundo o princípio de Franck-Condon, envolverá níveis vibrônicos de maior energia e é seguido da desativação térmica dentro do mesmo poço de potencial até o orbital molecular não-ocupado de menor energia (Lowest Unoccupied Molecular Orbital, LUMO), ou seja, ocorre um decaimento térmico sem variação na multiplicidade de spin, denominado conversão interna. Após a conversão interna, pode existir o cruzamento intersistema, no qual ocorre a alteração da multiplicidade de spin, o que leva a um novo conjunto de poços de potencial e novos estados excitados possíveis de serem atingidos. Este processo é facilitado ...

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Organometallic complexes of transition metals in luminescent cell imaging applications

Cited by 136 publications

References 60 publications

Re(I) carbonyl complexes: Multimodal platforms for inorganic chemical biology

Re(I) carbonyl complexes: Multimodal platforms for inorganic chemical biology

Underestimated Potential of Organometallic Rhenium Complexes as Anticancer Agents

A importância do estado excitado 3MLCT de compostos de Ru(II), Re(I) e Ir(III) no desenvolvimento de fotossensores, OLEDS e fotorredução de CO2

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