Organometallic tin complexes derived from 2-guanidinobenzimidazole

Cytotoxic activity, X-ray crystal structures and spectroscopic characterization of cobalt(II), copper(II) and zinc(II) coordination compounds with 2-substituted benzimidazoles

“…Complexes with 2-substituted benzimidazole have cytotoxic [25][26][27], antiviral [27] and antiamoebic activity [28]. We have investigated the coordination behavior of benzazole derivatives with transition metal ions, and their structural and chemical properties [29][30][31][32][33][34][35][36][37][38][39][40]. Recently, we reported on the structural, antibacterial and antineoplasic activity of a series of benzimidazole derivatives [41].…”

Synthesis and Structure of Sulfur Derivatives from 2-Aminobenzimidazole

“…With separation purposes, this mixture was dissolved in ethanol. 2-Methylthio-4H- [1,3,5]thiadiazino [3,4-a]benzimidazole-4-thione (7) was isolated from the mixture as an insoluble yellow solid and after recrystallization from chloroform, it was obtained as yellow crystals in 15% yield. 2-Aminobenzimidazole-1-carbodithioic acid methyl ester (8) precipitated from the ethanol solution, as yellow crystals in 40% yield as the previously described polymorph [15].…”

“…We are currently investigating the structures of biologically active benzofused nitrogen heterocycles such as 2-aminobenzazoles [1][2][3][4]. They are versatile from the structural point of view because of their free lone pairs, labile hydrogen atoms, and planar delocalized acyclic groups.…”

NMR study of the coordinating behavior of 2,6-bis(benzimidazol-2?-yl)pyridine

“…This study is part of our continuing interest in the coordinating ability of aromatic nitrogenated molecules bearing sp 2 nitrogen atoms as present in pyrrole, pyridine, imines, anilines, or imidazole, especially because they can be part of strongly basic polydentate ligands [10][11][12][13][14][15][16][17][18][19][20][21][22]. Aromatic polydentate compounds show different behavior compared to their aliphatic analogs as a consequence of their planar conformation, which allows in some cases increased stability and better crystallizing ability.…”

“…Aromatic polydentate compounds show different behavior compared to their aliphatic analogs as a consequence of their planar conformation, which allows in some cases increased stability and better crystallizing ability. The polyfunctionality in benzimidazole containing ligands induces tautomeric and conformational equilibria in solution, which makes the assessment of the actual coordinating structures difficult; even more, these equilibria change upon coordination [15][16][17][18]. Therefore it is important to establish the actual tautomers or conformers in the free ligands as well as in their coordinated forms, which can be distinguished by a careful NMR study.…”