Organopalladium approaches to bicyclic heteraotom containing prostaglandin analogues

Abstract

CHAPTER I. INTRODUCTION 1 CHAPTER II. SYNTHESIS OF HETEROCYCLIC PROSTAGLANDIN ENDOPEROXIDE ANALOGOUS 13 Conclusion 55 Experimental 56 CHAPTER III. SYNTHESIS OF 7-OXA PROSTAGLANDIN ENDOPEROXIDE ANALOGUES 79 Conclusion 100 Experimental 101 CHAPTER IV. ORGANOCOPPER-ORGANOMERCURY CROSS-COUPLING REACTIONS 116 The following chapter describes the results of work directed towards the synthesis of thiophene containing prostaglandin analogues. Chapter III describes the synthesis of several 7-oxa prostaglandin analogues. Chapter IV gives the results of the exploration of a new reaction for the alkylation of organomercurials with organocuprates, a reaction we hoped would be useful in several prostaglandin syntheses. Lastly, Chapter V briefly summarizes the results of this research and presents some suggestions for future work.