2023
DOI: 10.31857/s0869813923100059
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Organophospate-Induced Pathology: Mechanisms of Development, Principles of Therapy and Features of Experimental Studies

N. V. Goncharov,
D. A. Belinskaia,
P. V. Avdonin

Abstract: Organophosphates (OP) are one of the most common neurotoxic xenobiotics. In acute OP poisoning, as a result of suppression of synaptic acetylcholinesterase (AChE) activity, a cholinergic syndrome develops, which can transform into status epilepticus. Within a few days after acute poisoning, the so-called an intermediate syndrome can develop, which is associated with prolonged inhibition of AChE, desensitization of nicotinic receptors, and functional degradation of synapses and muscle fibers. In 10–20 days afte… Show more

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