Organophosphate ester flame retardants and plasticizers in human placenta in Eastern China

Ding, Jinjian; Zhang, Xu; Huang, Wei; Feng, Limin; Yang, Fangxing

doi:10.1016/j.scitotenv.2016.02.171

Cited by 211 publications

(81 citation statements)

References 45 publications

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“…Since the phasing-out of polybrominated diphenyl ethers (PBDEs) in 2005, the production and use of TDCIPP has been increased and it can now be detected across the globe in various environments, such as indoor air in the US (up to 56.08 mg/g) (Stapleton et al, 2009) and in China (14.3e40.1 mg/g) (Yang et al, 2013;He et al, 2015), surface water (855 ng/L; Shi et al, 2016), and biota samples (e.g., freshwater fish: 89 ng/g lipid wt; Hallanger et al, 2015). TDCIPP or its major metabolite [bis (1, 3-dichloro-2-propyl) phosphate, BDCIPP] has also been detected in human breast milk (5.1 ng/g lipid wt; Sundkvist et al, 2010), urine (11 ng/ ml; Butt et al, 2014), and placenta (82.8 ng/g lipid wt; Ding et al, 2016). Moreover, TDCIPP in house dust has proved to be correlated with decreased levels of circulating thyroid hormones in humans (Meeker and Stapleton, 2010).…”

Section: Introductionmentioning

confidence: 99%

Tris (1, 3-dichloro-2-propyl) phosphate induces apoptosis and autophagy in SH-SY5Y cells: Involvement of ROS-mediated AMPK/mTOR/ULK1 pathways

Zhou

Guo

et al. 2017

Food and Chemical Toxicology

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Section: Introductionmentioning

confidence: 99%

Tris (1, 3-dichloro-2-propyl) phosphate induces apoptosis and autophagy in SH-SY5Y cells: Involvement of ROS-mediated AMPK/mTOR/ULK1 pathways

Zhou

Guo

et al. 2017

Food and Chemical Toxicology

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“…TDCPP is a member of CPEs (Meeker and Stapleton ; van der Veen and de Boer ; Betts ). With the accumulation of TDCPP exposed to the environment and the transmission of the food chains, TDCPP could be detected in human urine, placenta, and breast milk (Sundkvist et al ; Ding et al ), and there are increasing numbers of people concern about its toxicity to human health, especially on the human reproduction.…”

Section: Introductionmentioning

confidence: 99%

Tris(1,3‐dichloro‐2‐propyl) phosphate disturbs mouse embryonic development by inducing apoptosis and abnormal DNA methylation

Yin

Chen

et al. 2019

Environ and Mol Mutagen

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Tris(1,3‐dichloro‐2‐propyl) phosphate (TDCPP) is a kind of additive flame retardants (FRs) and was found to affect early embryonic development in zebrafish; however, there are few studies to investigate whether TDCPP will disturb the development of early mouse embryos. In our studies, we used mouse embryos as models to study the toxicology of TDCPP on the early embryos. The results showed that TDCPP disturbed the development of early mouse embryos in a dose‐dependent manner. 10 μM TDCPP decreased the blastocyst formation and 100 μM TDCPP was a lethal concentration for the mouse embryos. We proved that TDCPP was detrimental to embryonic development potential by increasing the reactive oxygen species level and inducing early apoptosis. Furthermore, TDCPP changed the DNA methylation patterns of imprinted genes in treated blastocysts. The methylation of H19 and Snrpn promoter regions was increased from 37.67% to 46.00% and 31.56% to 44.38% in treated groups, respectively. In contrast, Peg3 promoter region methylation was declined from 86.55% to 73.27% in treated embryos. Taken together, our results demonstrated that TDCPP could adversely impair the early embryonic development in mouse. Environ. Mol. Mutagen. 2019. © 2019 Wiley Periodicals, Inc.

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“…Human exposure to these FRs may therefore arise from a number of routes of exposure. It is therefore unsurprising that both TCEP and TCIPP are found in human serum (Zhao et al, 2016), urine (Van den Eede, Neels, Jorens, & Covaci, 2013), milk (Sundkvist et al, 2010) and placenta (Ding, Xu, Huang, Feng, & Yang, 2016). TCEP and TCIPP may therefore pose a significant risk to human health.…”

Section: Introductionmentioning

confidence: 99%

A toxicogenomics approach to screen chlorinated flame retardants tris(2‐chloroethyl) phosphate and tris(2‐chloroisopropyl) phosphate for potential health effects

Krivoshiev

Beemster

Sprangers

et al. 2017

J of Applied Toxicology

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Tris(2-chloroethyl) phosphate (TCEP) is a pervasive flame retardant that has been identified as a chemical of concern given its health effects and therefore its use has since been tightly regulated. Tris(2-chloroisopropyl) phosphate (TCIPP), an analogue of TCEP, is believed to be its replacement. However, compared to TCEP, little is known of the toxicological impacts of TCIPP. We used RNA sequencing as unbiased and sensitive tool to identify and compare effects on a transcriptome level of TCEP and TCIPP in the human hepatocellular carcinoma cell line, HepG2. We identified that compared to other flame retardants, TCEP and TCIPP had little cytotoxicity. Treatment with sub-cytotoxic concentrations of the two compounds revealed that both chemicals elicited similar effects; both compounds were found to affect genes involved in immune responses and steroid hormone biosynthesis, while also affecting xenobiotic metabolism pathways in a similar manner. Specifically for effects on immune responses, both compounds were shown to alter the expression of the receptor of the potent and pleiotropic complement component, C5a. Additionally, expression of genes encoding for effector proteins involved in the complement cascade along with other potent inflammatory regulators were found altered in response to TCEP and TCIPP, further emphasizing their potential effects on immune function. Taken together, given that TCIPP elicited similar effects compared to TCEP, and at lower concentrations, the potential health effects of TCIPP need to be further studied for a complete risk assessment of the compound.

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Organophosphate ester flame retardants and plasticizers in human placenta in Eastern China

Cited by 211 publications

References 45 publications

Tris (1, 3-dichloro-2-propyl) phosphate induces apoptosis and autophagy in SH-SY5Y cells: Involvement of ROS-mediated AMPK/mTOR/ULK1 pathways

Tris (1, 3-dichloro-2-propyl) phosphate induces apoptosis and autophagy in SH-SY5Y cells: Involvement of ROS-mediated AMPK/mTOR/ULK1 pathways

Tris(1,3‐dichloro‐2‐propyl) phosphate disturbs mouse embryonic development by inducing apoptosis and abnormal DNA methylation

A toxicogenomics approach to screen chlorinated flame retardants tris(2‐chloroethyl) phosphate and tris(2‐chloroisopropyl) phosphate for potential health effects

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