Organophosphate Pesticide Exposure and Breast Cancer Risk: A Rapid Review of Human, Animal, and Cell-Based Studies

Yang, Kailynn June; Lee, Jennifer; Park, Hannah Lui

doi:10.3390/ijerph17145030

Cited by 47 publications

(17 citation statements)

References 75 publications

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“…It can be noted that IARC classified some organophosphate pesticides as "probably carcinogenic to humans" (Group 2A) and "possibly carcinogenic to humans" (Group 2B) 10 . Endocrine disruption potential of pesticides has also been described in toxicological studies and recently in a review by Yang et al 7,60 , and could be particularly involved in hormone-dependent breast carcinogenesis, as some pesticides are known to mimic estrogen functions 57,61 . Indeed, azole fungicides, including imazalil, for which we found high correlations with NMF Component 1, have been related to inhibition of estrogen biosynthesis in some studies 62 .…”

Section: Discussionmentioning

confidence: 96%

Prospective association between dietary pesticide exposure profiles and postmenopausal breast-cancer risk in the NutriNet-Santé cohort

Rebouillat

Vidal

Cravedi

et al. 2021

International Journal of Epidemiology

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Background Some pesticides, used in large quantities in current agricultural practices all over Europe, are suspected of adverse effects on human reproductive health (breast and prostate cancers), through mechanisms of endocrine disruption and possible carcinogenic properties, as observed in agricultural settings. However, evidence on dietary pesticide exposure and breast cancer (BC) is lacking for the general population. We aimed to assess the associations between dietary exposure to pesticides and BC risk among postmenopausal women of the NutriNet-Santé cohort. Methods In 2014, participants completed a self-administered semi-quantitative food-frequency questionnaire distinguishing conventional and organic foods. Exposures to 25 active substances used in EU plant-protection products were estimated using a pesticide-residue database accounting for farming practices, from Chemisches und Veterinäruntersuchungsamt Stuttgart, Germany. Non-negative matrix factorization (NMF), adapted for data with excess zeros, was used to establish exposure profiles. The four extracted NMF components’ quintiles were introduced into Cox models estimating hazard ratio (HR) and 95% confidence interval (95% CI), adjusted for known confounding factors. Results A total of 13 149 postmenopausal women were included in the analysis (169 BC cases, median follow-up = 4.83 years). Negative associations between Component 3, reflecting low exposure to synthetic pesticides, and postmenopausal BC risk were found [HRQ5 = 0.57; 95% CI (0.34; 0.93), p-trend = 0.006]. Positive association between Component 1 score (highly correlated to chlorpyrifos, imazalil, malathion, thiabendazole) and postmenopausal BC risk was found specifically among overweight and obese women [HRQ5 = 4.13; 95% CI (1.50; 11.44), p-trend = 0.006]. No associations were detected for the other components. Conclusion These associations suggest a potential role of dietary pesticide exposure on BC risk. Further research is needed to investigate the mechanisms and confirm these results in other populations.

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Section: Discussionmentioning

confidence: 96%

Prospective association between dietary pesticide exposure profiles and postmenopausal breast-cancer risk in the NutriNet-Santé cohort

Rebouillat

Vidal

Cravedi

et al. 2021

International Journal of Epidemiology

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“…The authors proposed that EBV presence affects the response of BC cells to nicotine [ 103 ]. In addition, it has been shown that organophosphate pesticides such as malathion or parathion are related to BC by in vitro and in vivo approaches [ 104 , 105 , 106 ]. Notably, it was reported that chlorpyrifos, an organophosphate pesticide, can promote EBV lytic cycle activation by promoting BZLF1 expression by oxidative stress in a lymphoblastoid cell line.…”

Section: Ebv In Breast Cancer: Potential Mechanismsmentioning

confidence: 99%

Epstein–Barr Virus Association with Breast Cancer: Evidence and Perspectives

Arias-Calvachi

Blanco

Calaf

et al. 2022

Biology

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Epstein–Barr virus (EBV) is an enveloped DNA virus that belongs to the gamma Herpesviridae family. The virus establishes a latent/lytic persistent infection, though it can be involved in cancer development in some subjects. Indeed, evidence supports an etiological role of EBV in undifferentiated nasopharyngeal carcinoma (NPC), a subset of gastric carcinomas and lymphomas. Additionally, EBV has been detected in breast carcinomas (BCs) although its role has not been established. In this review, we summarize epidemiological information regarding the presence of EBV in BC and we propose mechanistic models. However, additional epidemiological and experimental evidence is warranted to confirm these models.

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“…On the other hand, estradiol metabolism may result in quinone derivatives, which directly replace base pairs from DNA through depurination, and can also alter the DNA repairing process (109)(110)(111). It has been reported that estrogens are potent mammary tumor promoters influencing post-initiation events through epigenetic mechanisms.…”

Section: Parathion and Malathion Induce Metabolic Alterationsmentioning

confidence: 99%

Signs of carcinogenicity induced by parathion, malathion, and estrogen in human breast epithelial cells (Review)

2021

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Cancer development is a multistep process that may be induced by a variety of compounds. Environmental substances, such as pesticides, have been associated with different human diseases. Organophosphorus pesticides (OPs) are among the most commonly used insecticides. Despite the fact that organophosphorus has been associated with an increased risk of cancer, particularly hormone-mediated cancer, few prospective studies have examined the use of individual insecticides. Reported results have demonstrated that OPs and estrogen induce a cascade of events indicative of the transformation of human breast epithelial cells. In vitro studies analyzing an immortalized non-tumorigenic human breast epithelial cell line may provide us with an approach to analyzing cell transformation under the effects of OPs in the presence of estrogen. The results suggested hormone-mediated effects of these insecticides on the risk of cancer among women. It can be concluded that, through experimental models, the initiation of cancer can be studied by analyzing the steps that transform normal breast cells to malignant ones through certain substances, such as pesticides and estrogen. Such substances cause genomic instability, and therefore tumor formation in the animal, and signs of carcinogenesis in vitro. Cancer initiation has been associated with an increase in genomic instability, indicated by the inactivation of tumor-suppressor genes and activation of oncogenes in the presence of malathion, parathion, and estrogen. In the present study, a comprehensive summary of the impact of OPs in human and rat breast cancer, specifically their effects on the cell cycle, signaling pathways linked to epidermal growth factor, drug metabolism, and genomic instability in an MCF-10F estrogen receptor-negative breast cell line is provided.

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Organophosphate Pesticide Exposure and Breast Cancer Risk: A Rapid Review of Human, Animal, and Cell-Based Studies

Cited by 47 publications

References 75 publications

Prospective association between dietary pesticide exposure profiles and postmenopausal breast-cancer risk in the NutriNet-Santé cohort

Prospective association between dietary pesticide exposure profiles and postmenopausal breast-cancer risk in the NutriNet-Santé cohort

Epstein–Barr Virus Association with Breast Cancer: Evidence and Perspectives

Signs of carcinogenicity induced by parathion, malathion, and estrogen in human breast epithelial cells (Review)

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