Organophosphate poisoning presenting as out-of-hospital cardiac arrest: A clinical challenge

Kuo, Huey Shiuen; Yen, Chih Chieh; Wu, Chun I.; Li, Yi Heng; Chen, Ju Yi

doi:10.1016/j.jccase.2017.03.006

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…The signs of OPP may be classified as effects secondary to nicotinic, muscarinic, and CNS receptor overstimulation. 6 Clinical presentation depends on the specific agent involved, the type of exposure and the quantity absorbed 5 .Miosis was also the most significant sign in the present patient (99.65%). This finding is similar to several studies.…”

Section: Discussionmentioning

confidence: 63%

“… 2 , 4 , 16 Pralidoxime is a biochemical antidote for OPP; its beneficial effects include reactivation of cholinesterase by cleavage of phosphorylated active sites, direct reaction and detoxification of unbounded OPCs, and an endogenous anticholinergic effect. 3 - 5 This therapy for OPP also applies to the emergency treatment for sarin, a typical drug of chemical weapons of mass destruction. 7 , 14 …”

Section: Discussionmentioning

confidence: 99%

“…As limited studies have been done related to the cardiac toxicity therefore frequency, extent and pathogenesis are not well defined, so many physicians may not be fully aware of the complications. 5 , 6…”

Section: Introductionmentioning

confidence: 99%

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Effect of Organophasphate poisoning among patients reporting at a tertiary healthcare facility of Sindh Pakistan

Shaikh

Khaskheli

Meraj³

et al. 2018

Pak J Med Sci

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Objective:To determine the effect of organophosphate poisoning (OPP) among patients at tertiary healthcare, Pakistan.Methods:This cohort study was conducted over a six-year period (January 2011 to December 2016) of OPP patients admitted to the intensive care unit of Peoples University of Medical & Health Sciences for Women SBA, Hospital Pakistan and their outcome was determined.Results:Total mortality was 17.39% (84 deaths in 483 patients, excluding those referred to Karachi). Out of these 84 deaths, 65 patients (13.46%) expired due to cardiorespiratory failure, 17 deaths (3.52%) followed due to complication of mechanical ventilation & ICU acquired infection and two deaths (0.41%) occurred due to renal failure. The major cause of poisoning was deliberate self-harm /suicidal intention (93.02%), with gender distribution of female (57.07%) and male (35.95%), followed by unintentional/accidental exposure (6.98%) in males. The intensive supportive treatment, precise and appropriate respiratory care, and adequate amount of atropine and pralidoxime doses are keys to reducing the OPP patient’s mortality.Conclusion:Organophosphate poisoning (OPP) intoxication is common in female gender. The easy availability of these harmful compounds has resulted in increased mortality either by accidental exposure or most often by the deliberate suicidal attempt.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

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Effect of Organophasphate poisoning among patients reporting at a tertiary healthcare facility of Sindh Pakistan

Shaikh

Khaskheli

Meraj³

et al. 2018

Pak J Med Sci

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show abstract

“…Intriguingly, a nationwide population-based cohort study conducted by Hung et al, 2015 confirmed that, individuals undergone OP poisoning have greater incidence rates of congestive heart failure than a non-OP poisoning cohort. Notably, out-of-hospital cardiac arrest may also be an outcome of OP intoxication ( Kuo et al, 2017 ). Statistical analyses on a cohort of 7557 individual suggested that, occupational exposure to pesticides including OPs might play a role in the development of cardiovascular diseases including coronary heart disease ( Berg et al, 2019 ).…”

Section: Cardiotoxicitymentioning

confidence: 99%

Synergistic action of organophosphates and COVID-19 on inflammation, oxidative stress, and renin-angiotensin system can amplify the risk of cardiovascular maladies

Rajak

Roy

Podder

et al. 2022

Toxicology and Applied Pharmacology

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“…Washington, DC, US, Government Printing Office) [17]. In humans, many reports of acute poisoning of organophosphates research suggested that organophosphate acts similar to nerve agents and may cause muscle failure, resulting in a patient's death [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Simple and Fast Pesticide Nanosensors: Example of Surface Plasmon Resonance Coumaphos Nanosensor

et al. 2023

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Here, a molecular imprinting technique was employed to create an SPR-based nanosensor for the selective and sensitive detection of organophosphate-based coumaphos, a toxic insecticide/veterinary drug often used. To achieve this, UV polymerization was used to create polymeric nanofilms using N-methacryloyl-l-cysteine methyl ester, ethylene glycol dimethacrylate, and 2-hydroxyethyl methacrylate, which are functional monomers, cross-linkers, and hydrophilicity enabling agents, respectively. Several methods, including scanning electron microscopy (SEM), atomic force microscopy (AFM), and contact angle (CA) analyses, were used to characterize the nanofilms. Using coumaphos-imprinted SPR (CIP-SPR) and non-imprinted SPR (NIP-SPR) nanosensor chips, the kinetic evaluations of coumaphos sensing were investigated. The created CIP-SPR nanosensor demonstrated high selectivity to the coumaphos molecule compared to similar competitor molecules, including diazinon, pirimiphos-methyl, pyridaphenthion, phosalone, N-2,4(dimethylphenyl) formamide, 2,4-dimethylaniline, dimethoate, and phosmet. Additionally, there is a magnificent linear relationship for the concentration range of 0.1–250 ppb, with a low limit of detection (LOD) and limit of quantification (LOQ) of 0.001 and 0.003 ppb, respectively, and a high imprinting factor (I.F.4.4) for coumaphos. The Langmuir adsorption model is the best appropriate thermodynamic approach for the nanosensor. Intraday trials were performed three times with five repetitions to statistically evaluate the CIP-SPR nanosensor’s reusability. Reusability investigations for the two weeks of interday analyses also indicated the three-dimensional stability of the CIP-SPR nanosensor. The remarkable reusability and reproducibility of the procedure are indicated by an RSD% result of less than 1.5. Therefore, it has been determined that the generated CIP-SPR nanosensors are highly selective, rapidly responsive, simple to use, reusable, and sensitive for coumaphos detection in an aqueous solution. An amino acid, which was used to detect coumaphos, included a CIP-SPR nanosensor manufactured without complicated coupling methods and labelling processes. Liquid chromatography with tandem mass spectrometry (LC/MS-MS) studies was performed for the validation studies of the SPR.

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Organophosphate poisoning presenting as out-of-hospital cardiac arrest: A clinical challenge

Cited by 6 publications

References 10 publications

Effect of Organophasphate poisoning among patients reporting at a tertiary healthcare facility of Sindh Pakistan

Effect of Organophasphate poisoning among patients reporting at a tertiary healthcare facility of Sindh Pakistan

Synergistic action of organophosphates and COVID-19 on inflammation, oxidative stress, and renin-angiotensin system can amplify the risk of cardiovascular maladies

Simple and Fast Pesticide Nanosensors: Example of Surface Plasmon Resonance Coumaphos Nanosensor

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