Organophosphorous pesticide exposures and sperm quality

Perry, Melissa J.; Venners, Scott A.; Chen, Xing; Liu, Xue; Tang, Genfu; Huang, Xing; Barr, Dana Boyd; Xu, Xiping

doi:10.1016/j.reprotox.2010.08.006

Cited by 66 publications

(42 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Relationships between the persistent organic pollutants (POPs) DDT and HCH and sperm characteristics were found in five studies (Aneck-Hahn et al, 2007; Haugen et al, 2011; Khan et al, 2010; Messaros et al, 2009; Pant et al, 2007). Organophosphates (OP) were shown to be associated with lowered sperm parameters in six of the studies (Hossain et al, 2010; Perez-Herrera et al, 2008; Perry et al, 2007, 2011; Recio-Vega et al, 2008; Yucra et al, 2008). One study found an association between the pesticide abamectin and decreased sperm motility (Celik-Ozenci et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Environmental and occupational pesticide exposure and human sperm parameters: A systematic review

2013

Self Cite

View full text Add to dashboard Cite

Of continuing concern are the associations between environmental or occupational exposures to pesticides and semen quality parameters. Prior research has indicated that there may be associations between exposure to pesticides of a variety of classes and decreased sperm health. The intent of this review was to summarize the most recent evidence related to pesticide exposures and commonly used semen quality parameters, including concentration, motility and morphology. The recent literature was searched for studies published between January, 2007 and August, 2012 that focused on environmental or occupational pesticide exposures. Included in the review are 17 studies, 15 of which reported significant associations between exposure to pesticides and semen quality indicators. Two studies also investigated the roles genetic polymorphisms may play in the strength or directions of these associations. Specific pesticides targeted for study included dichlorodiphenyltrichloroethane (DDT), hexachlorocyclohexane (HCH), and abamectin. Pyrethroids and organophosphates were analyzed as classes of pesticides rather than as individual compounds, primarily due to the limitations of exposure assessment techniques. Overall, a majority of the studies reported significant associations between pesticide exposure and sperm parameters. A decrease in sperm concentration was the most commonly reported finding among all of the pesticide classes investigated. Decreased motility was also associated with exposures to each of the pesticide classes, although these findings were less frequent across studies. An association between pesticide exposure and sperm morphology was less clear, with only two studies reporting an association. The evidence presented in this review continues to support the hypothesis that exposures to pesticides at environmentally or occupationally relevant levels may be associated with decreased sperm health. Future work in this area should focus on associations between specific pesticides or metabolic products and sperm quality parameters. Analysis of effects of varying genetic characteristics, especially in genes related to pesticide metabolism, also needs further attention.

show abstract

Section: Resultsmentioning

confidence: 99%

Environmental and occupational pesticide exposure and human sperm parameters: A systematic review

2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…They pointed out a disruptive role of pesticides on sex hormones activities, which could lead to secretory dysfunction of male accessory glands (19). Sperm motility decrease was also reported in cases of specific pesticide exposure such as pyrethroids (20), organochlorines (21,22), and organophosphates (23,24), as well as multiple pesticide exposure (25). In a synthesis review of four cross-sectional studies of the INUENDO project assessing the impact of persistent organic pollutants (POPs) on human fertility (26), PCB congener CB-153 blood levels were inversely related to sperm motility and to neutral α-glucosidase activity, a marker of epididymal function.…”

Section: Discussionmentioning

confidence: 98%

Routine assessment of occupational exposure and its relation to semen quality in infertile men: a cross-sectional study

et al. 2017

View full text Add to dashboard Cite

Background/aim: Concerns about the detrimental effects of occupational and environmental exposure on male reproductive function have been raised by reports of declining sperm quality over the last decades. The aim of this study was to investigate the association between altered semen parameters and exposure to occupational risk factors as assessed by questionnaire. Materials and methods:We conducted a cross-sectional questionnaire-based study among a population of 2122 men who underwent andrological investigation for couple infertility. All participants were interviewed and their semen samples were analyzed. Information about medical history and occupational exposure was used to classify participants into exposed and unexposed groups.Results: Exposure to pesticides was associated with a significantly higher risk of asthenozoospermia (adjusted odds ratio [OR] = 1.6; 95% CI, 1.0-2.4) and necrozoospermia (OR = 2.6; 95% CI, 1.4-4.7). Exposure to cement was found to be correlated with a higher risk of oligozoospermia (OR = 1.1; 95% CI, 0.9-1.4). There was no association between semen impairment and exposure to solvents, excess heat, or mechanical vibrations. Conclusion:We found an association between self-reported occupational exposure and altered semen parameters. These results support the usefulness of questionnaires for routine assessment and management of occupational exposures in infertile men.

show abstract

“…al., 2008). Organophospates are associated with decreased sperm concentration, ejaculate volume and total sperm count (Perry et al, 2011). Chiu et.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Pesticide Residue Levels in Vegetables sold in some Markets in Lagos State, Nigeria

Njoku¹,

Ezeh²,

Obidi³

et al. 2017

Nig. J. Biotechnol

View full text Add to dashboard Cite

This study investigated pesticide residue levels in the two vegetables commonly eaten in Lagos state Nigeria. The vegetables (Telfairia occidentalis and Celosia argentea) were purchased from six markets (Oyingbo, Mile 12, Mushin, Ajah, Agege and Festac) in Lagos. The pesticide residue levels were determined using gas chromatography/mass spectrometry. Data obtained were statistically analysed using graph pad prism 6.0 software and were compared with WHO limits. The vegetables from all the markets had pesticide residue level above the WHO lower limit (0.02 mg/kg). The two vegetables from Oyingbo and Mile 12 markets had total pesticide residue levels above the WHO upper limit (0.7 mg/kg). T. occidentalis from Oyingbo market had the highest total pesticide residue level (2.35mg/kg) and the highest number of pesticides while C. argentea from Agege market had the least total pesticide residue level (0.08mg/kg).Aladrin was found in the two vegetables from all markets and generally more pesticide residue was found in the tissues of T. occidentalis than in the tissues of C. argentea. Significant differences (P<0.05; P<0.01) were noticed between some pesticides in T. occidentalis from Oyingbo and some pesticides in the vegetables from the other markets.Although the hazard quotient and hazard index values (being less than 1 and 0.2 respectively) indicate that there will be no health risk in consuming the vegetable, some of pesticides residues were above the maximum residue levels. The presence of pesticides in the vegetables calls for strict regulation of the application of the pesticides in farms and preservation chambers. This will help in preventing some of the diseases and other problems associated with pesticide accumulation.

show abstract

Organophosphorous pesticide exposures and sperm quality

Cited by 66 publications

References 24 publications

Environmental and occupational pesticide exposure and human sperm parameters: A systematic review

Environmental and occupational pesticide exposure and human sperm parameters: A systematic review

Routine assessment of occupational exposure and its relation to semen quality in infertile men: a cross-sectional study

Assessment of Pesticide Residue Levels in Vegetables sold in some Markets in Lagos State, Nigeria

Contact Info

Product

Resources

About