Organophosphorus and pyrethroid insecticide urinary metabolite concentrations in young children living in a southeastern United States city

Naeher, Luke P.; Tulve, Nicolle S.; Egeghy, Peter; Barr, Dana Boyd; Adetona, Olorunfemi; Fortmann, Roy C.; Needham, Larry L.; Bozeman, Elizabeth; Hilliard, Aaron; Sheldon, Linda

doi:10.1016/j.scitotenv.2009.10.022

Cited by 95 publications

(65 citation statements)

References 25 publications

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“…In fact, at the end of the 15-day dosing period, the urinary 3-PBA concentration in rats was 41.50 g/L (0.11 ± 0.01 g in a mean urinary volume of 2.65 mL), whereas in children the median (as 50th percentile) value ranged from 0.3 g/L to 5.0 g/L according to the different studies Naeher et al, 2010;Becker et al, 2006;Zartarian et al, 2012). However, 3-PBA levels in children were also found as high as 20 g/L at the 95th percentile.…”

Section: Discussionmentioning

confidence: 93%

Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats

et al. 2013

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a b s t r a c tPesticide exposure during brain development could represent an important risk factor for the onset of neurodegenerative diseases. Previous studies investigated the effect of permethrin (PERM) administered at 34 mg/kg, a dose close to the no observable adverse effect level (NOAEL) from post natal day (PND) 6 to PND 21 in rats. Despite the PERM dose did not elicited overt signs of toxicity (i.e. normal body weight gain curve), it was able to induce striatal neurodegeneration (dopamine and Nurr1 reduction, and lipid peroxidation increase). The present study was designed to characterize the cognitive deficits in the current animal model. When during late adulthood PERM treated rats were tested for spatial working memory performances in a T-maze-rewarded alternation task they took longer to choose for the correct arm in comparison to age matched controls. No differences between groups were found in anxiety-like state, locomotor activity, feeding behavior and spatial orientation task. Our findings showing a selective effect of PERM treatment on the T-maze task point to an involvement of frontal cortico-striatal circuitry rather than to a role for the hippocampus. The predominant disturbances concern the dopamine (DA) depletion in the striatum and, the serotonin (5-HT) and noradrenaline (NE) unbalance together with a hypometabolic state in the medial prefrontal cortex area. In the hippocampus, an increase of NE and a decrease of DA were observed in PERM treated rats as compared to controls. The concentration of the most representative marker for pyrethroid exposure (3-phenoxybenzoic acid) measured in the urine of rodents 12 h after the last treatment was 41.50 g/L and it was completely eliminated after 96 h.

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Section: Discussionmentioning

confidence: 93%

Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats

et al. 2013

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“…[1][2][3][4] Data from a substantial body of experimental and epidemiological research suggest that low-level prenatal and early postnatal pesticide exposures adversely affect neurodevelopment. 5 In previous epidemiological studies associations between prenatal organochlorine and/or organophosphorus (OP) insecticide exposures and neurodevelopment were evaluated.…”

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confidence: 99%

Impact of Prenatal Exposure to Piperonyl Butoxide and Permethrin on 36-Month Neurodevelopment

et al. 2011

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WHAT'S KNOWN ON THIS SUBJECT:Pyrethroid insecticides and the pyrethroid synergist piperonyl butoxide are potential neurodevelopmental toxicants and have not been evaluated for developmental toxicity. In this study the effects of prenatal exposure to piperonyl butoxide and permethrin on neurodevelopment in children aged 36 months were examined. WHAT THIS STUDY ADDS:A significant inverse association was observed between prenatal exposure to piperonyl butoxide, a pyrethroid synergist, and 36-month neurodevelopment. No significant association was observed between prenatal exposure to permethrin and adverse neurodevelopment. abstract OBJECTIVE: Recent pesticide-monitoring results suggest that a shift in residential pesticide exposure from organophosphorus insecticides to pyrethroid insecticides has occurred. Pyrethroid insecticides are potential neurodevelopmental toxicants and have not been evaluated for developmental toxicity. Our objective was to explore the association between prenatal exposure to permethrin (a common pyrethroid) and piperonyl butoxide (a pyrethroid synergist) and 36-month neurodevelopment. METHODS:Participants is this study were part of a prospective cohort of black and Dominican mothers and newborns living in low-income neighborhoods in New York City. We examined 36-month cognitive and motor development (using the Bayley Scales of Infant Development, second edition) as a function of permethrin levels measured in maternal and umbilical cord plasma collected on delivery and permethrin and piperonyl butoxide levels measured in personal air collected during pregnancy. All models were controlled for gender, gestational age, ethnicity, maternal education, maternal intelligence, quality of the home environment, and prenatal exposure to environmental tobacco smoke and chlorpyrifos.

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“…Of the four studies reporting the association between self-reported insecticide use and pyrethroid exposure, a significant positive association between selfreported insecticide use and pyrethroid exposure was reported by Becker et al in Germany and by Lu et al in the US; a non-significant positive association between selfreported use of outdoor spray and pyrethroid exposure was reported by Trunnelle et al, also in the US (60,64,72,75). Naeher et al reported the association between selfreported insecticide use and exposure to both pyrethroids and organophosphates in the US and found a significant association only for pyrethroids (69). It is likely that the association between domestic insecticide use and pyrethroid exposure from studies in the US is more consistent than the association with organophosphate exposure; this is because the use of pyrethroid active ingredients in domestic insecticides has increased due to the the implementation of stricter regulations on the sale of organophosphates for domestic use (76).…”

Section: Products In the Home: Personal Care Products And Insecticidesmentioning

confidence: 90%

Assessing exposure of young children to common endocrine-disrupting chemicals in the home environment: a review and commentary of the questionnaire-based approach

English

Healy²,

Jagals³

et al. 2015

Reviews on Environmental Health

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AbstractAlthough infants and young children are particularly vulnerable to endocrine disrupting chemical (EDC) exposure, there is an absence of comprehensive exposure data for this age group. As young children spend the majority of their time indoors, improved methods of exposure assessment are needed to characterise the health risks from exposures in the home environment. Biologic assessment, which has been considered the gold standard for exposure assessment in recent years, is difficult to conduct in young children. Questionnaires are an alternative and indirect method of predicting exposure, which may overcome some of the limitations of direct exposure assessment.The feasibility of using a questionnaire-based approach to predict exposure of young children to EDCs in the home has yet to be comprehensively reviewed. Moreover, there is no one questionnaire that has been validated for predicting the exposure of infants to common EDCs in the home.The aim of this review is to discuss the use and validation of the questionnaire-based approach to predict exposure of children to chemicals from three common classes of EDCs in the home, namely, plasticisers, flame retardants, and insecticides. We discuss the strengths and weaknesses of the questionnaire-based approach as well as the important pathways of exposure in the home environment, by which to guide the design and validation of future exposure questionnaires.The findings from our review indicate that the questionnaire-based approach is a valuable tool in the prediction of exposure to persistent organic pollutants, as well as to toxicants that have consistent patterns of exposure. With improvements to the design and validation process, the questionnaire-based approach may also prove to be a reliable instrument in predicting exposure to EDCs with short-half lives, including bisphenol A, phthalates, and pyrethroid and organophosphate insecticides.

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Organophosphorus and pyrethroid insecticide urinary metabolite concentrations in young children living in a southeastern United States city

Cited by 95 publications

References 25 publications

Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats

Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats

Impact of Prenatal Exposure to Piperonyl Butoxide and Permethrin on 36-Month Neurodevelopment

Assessing exposure of young children to common endocrine-disrupting chemicals in the home environment: a review and commentary of the questionnaire-based approach

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