Organophosphorus pesticides toxicity on brine shrimp artemia

Ali, Jawahar; Mohamed, A. Jamal; Kumar, Mohit; John, Akbar

doi:10.26480/jcleanwas.01.2018.23.26

Cited by 11 publications

(3 citation statements)

References 15 publications

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“…Up to now Artemia sp. has been widely used to test fungal toxins (Harwig and Scott, 1971), plant extract toxicity (Meyer et al, 1982), heavy metals (Martı́nez et al, 1999;Sarabia et al, 2008), cyanobacteria toxins (Jaki et al, 1999;Tokodi et al, 2018) and pesticides (Comeche et al, 2017;Gambardella et al, 2018;Jawahar et al, 2018). Artemia sp.…”

Section: Introductionmentioning

confidence: 99%

Efficient, fast and inexpensive bioassay to monitor benthic microalgae toxicity: Application to Ostreopsis species

et al. 2020

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Even though HPLC-MS is commonly used to quantify the toxin content of Ostreopsis spp. cells, there is a need to develop easy-to-use toxicological tests to set thresholds during Ostreopsis spp. blooms. The crustacean Artemia has been widely used to evaluate the presence and toxicity of chemicals and biological contaminants and we anticipated that it could also be useful to test Ostreopsis spp. toxicity. Its relevance was first assessed by investigating the variability of the toxic effects among Ostreopsis spp. strains and throughout the dinoflagellate life cycle in combination with chemical analyses of the toxinic content by UHPLC-HRMS. After testing the toxicity of fractions prepared from Ostreopsis spp. cells, the known ova-and paly-toxins were not the only toxic metabolites to Artemia franciscana, indicating that other toxic compounds synthesized by Ostreopsis spp. still remain to be identified. To extend the bioassay to in situ monitoring, the toxicity of the benthic microalgal consortium was tested during a natural bloom of Ostreopsis cf. ovata in the NW Mediterranean Sea. The results highlight the accuracy and sensitivity of the ecotoxicological assay with Artemia franciscana to assess the toxicity of Ostreopsis spp. blooms. Highlights► Artemia bioassay is relevant to evaluate Ostreopsis spp. Toxicity ► Ostreopsis spp. produce other toxic compounds than known ovatoxins ► Artemia bioassay could be used for bio-guided fractionation approach

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Section: Introductionmentioning

confidence: 99%

Efficient, fast and inexpensive bioassay to monitor benthic microalgae toxicity: Application to Ostreopsis species

et al. 2020

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“…At a concentration of 28 µg•L −1 , 90% mortality of the tested organisms was observed. The same concentration of Roundup ® converted to glyphosate, i.e., 28 µg•L −1 caused 50% mortality of test organisms after 24 h, and after 48 h the LC 50 value was 19 µg•L −1 [104]. Our results show that Kaput ® Premium herbicide has very similar LC 50 value as Roundup ® Classic Pro, namely 19 µg•L −1 .…”

Section: Crustacea Bioassay Testmentioning

confidence: 52%

The Influence of Herbicides to Marine Organisms Aliivibrio fischeri and Artemia salina

Vurm

Tajnaiová

Kofroňová

2021

Toxics

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The aim of this work was to determine the toxic effect of the most used herbicides on marine organisms, the bacterium Aliivibrio fischeri, and the crustacean Artemia salina. The effect of these substances was evaluated using a luminescent bacterial test and an ecotoxicity test. The results showed that half maximal inhibitory concentration for A. fischeri is as follows: 15minIC50 (Roundup® Classic Pro) = 236 µg.l−1, 15minIC50 (Kaput® Premium) = 2475 µg.l−1, 15minIC50 (Banvel® 480 S) = 2637 µg.l−1, 15minIC50 (Lontrel 300) = 7596 µg.l−1, 15minIC50 (Finalsan®) = 64 µg.l−1, 15minIC50 (glyphosate) = 7934 µg.l−1, 15minIC50 (dicamba) = 15,937 µg.l−1, 15minIC50 (clopyralid) = 10,417 µg.l−1, 15minIC50 (nonanoic acid) = 16,040 µg.l−1. Median lethal concentrations for A. salina were determined as follows: LC50 (Roundup® Classic Pro) = 18 µg.l−1, LC50 (Kaput® Premium) = 19 µg.l−1, LC50 (Banvel® 480 S) = 2519 µg.l−1, LC50 (Lontrel 300) = 1796 µg.l−1, LC50 (Finalsan®) = 100 µg.l−1, LC50 (glyphosate) = 811 µg.l−1, LC50 (dicamba) = 3705 µg.l−1, LC50 (clopyralid) = 2800 µg.l−1, LC50 (nonanoic acid) = 7493 µg.l−1. These findings indicate the need to monitor the herbicides used for all environmental compartments.

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“…The higher values observed in our experiment indicate that these two compounds (i.e., 2c and 4c ) have lower acute toxicity than bisphenol A or SDS. For organo-phosphoric compounds, such as malathion, LC 50 values of 1 to 17 mg/L were determined at 48 h, whereas for glyphosate LC 50 point estimates were lower than 1 mg/L [ 44 ]. To conclude, most of the compounds synthesized and evaluated in this paper were devoid of toxicity on Artemia nauplii, and the only two that manifested some toxicity seemed to be less toxic than those used widely in industrial compounds such as bisphenol A or SDS.…”

Section: Resultsmentioning

confidence: 99%

New Pyrrole Derivatives as Promising Biological Agents: Design, Synthesis, Characterization, In Silico, and Cytotoxicity Evaluation

Ivan

Bărbuceanu

Hotnog

et al. 2022

IJMS

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The current study describes the synthesis, physicochemical characterization and cytotoxicity evaluation of a new series of pyrrole derivatives in order to identify new bioactive molecules. The new pyrroles were obtained by reaction of benzimidazolium bromide derivatives with asymmetrical acetylenes in 1,2-epoxybutane under reflux through the Huisgen [3 + 2] cycloaddition of several ylide intermediates to the corresponding dipolarophiles. The intermediates salts were obtained from corresponding benzimidazole with bromoacetonitrile. The structures of the newly synthesized compounds were confirmed by elemental analysis, spectral techniques (i.e., IR, 1H-NMR and 13C-NMR) and single-crystal X-ray analysis. The cytotoxicity of the synthesized compounds was evaluated on plant cells (i.e., Triticum aestivum L.) and animal cells using aquatic crustaceans (i.e., Artemia franciscana Kellogg and Daphnia magna Straus). The potential antitumor activity of several of the pyrrole derivatives was studied by performing in vitro cytotoxicity assays on human adenocarcinoma-derived cell lines (i.e., LoVo (colon), MCF-7 (breast), and SK-OV-3 (ovary)) and normal human umbilical vein endothelial cells (HUVECs). The obtained results of the cytotoxicity assessment indicated that the tested compounds had nontoxic activity on Triticum aestivum L., while on Artemia franciscana Kellogg nauplii, only compounds 2c and 4c had moderate toxicity. On Daphnia magna, 4b and 4c showed high toxicity; 2a, 2b, and 2c moderate to high toxicity; only 4a and 4d were nontoxic. The compound-mediated cytotoxicity assays showed that several pyrrole compounds demonstrated dose- and time-dependent cytotoxic activity against all tested tumor cell lines, the highest antitumor properties being achieved by 4a and its homologue 4d, especially against LoVo colon cells.

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Organophosphorus pesticides toxicity on brine shrimp artemia

Cited by 11 publications

References 15 publications

Efficient, fast and inexpensive bioassay to monitor benthic microalgae toxicity: Application to Ostreopsis species

Efficient, fast and inexpensive bioassay to monitor benthic microalgae toxicity: Application to Ostreopsis species

The Influence of Herbicides to Marine Organisms Aliivibrio fischeri and Artemia salina

New Pyrrole Derivatives as Promising Biological Agents: Design, Synthesis, Characterization, In Silico, and Cytotoxicity Evaluation

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