Organoselenium compounds as antioxidants

Abstract

Reactive oxygen species (ROS) are responsible for many of civilization's diseases, including cancer, diabetes, and Alzheimer's disease, decomposition of products in the food industry, and deterioration of physicochemical properties of polymers and nanomaterials. In recent years, several organoselenium compounds have been synthesized and used as peroxide scavengers, which are the source of many antioxidant substances. This review aims to collect and divide the organoselenium compounds obtained in the last twelve years with antioxidant activity, which can prove helpful in a) medicine as supplements preventing diseases caused by oxidative stress, b) as food additives preventing oxidation, or c) in the materials industry as Se-containing nanoparticles and polymers. In addition, the most common methods for determining GPx-like antioxidant activity are presented.

Organic selenocompounds: are they the panacea for human illnesses?

“…, with biological activities have been synthesized in different laboratories. 125,179–208 Unfortunately, they have been rarely tested in models related to their recognized biological effects. For instance, in a recent elegant and rational study, 209 the neurochemical behavior of selenofluoxetine was compared with fluoxetine by quantifying the cerebral (hippocampal) serotonin levels in living mice.…”

Facile synthesis of chiral phenylselenides as novel antioxidants and cytotoxic agents

“…The ability to mimic the antioxidant selenoenzyme glutathione peroxidase (GPx) determines its high redox-modulating properties. 5 Over the years, they have also been proven to exhibit various biological activities including anticancer, anti-inammatory, and antibacterial. [6][7][8][9][10][11] However, issues associated with bioavailability and side effects remain major obstacles in the design of safe Se-therapeutics.…”

First Examples of Reactions of 3-Trimethylsilyl-2-Propynamides and Organic Diselenides: Synthesis of Novel Derivatives of Propynamides

“…Organoselenium compounds exhibit a variety of biological activities [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] including antitumor [10][11][12][13], antibacterial [13,14], antiviral [15,16] and glutathione peroxidase mimetic properties [17][18][19].…”

“…The most studied in terms of biological activity is 2-phenyl-1,2-benzoselenazol-3(2H)one (ebselen). This well-known selenium-containing heterocyclic drug exhibits antiinflammatory, neuroprotective and glutathione peroxidase mimetic properties [22][23][24][25][26]. Interestingly, ebselen also inhibits the SARS-CoV-2 viral replication [25,26].…”

“…Interestingly, ebselen also inhibits the SARS-CoV-2 viral replication [25,26]. This compound has been investigated in clinical trials as a therapeutic agent for the treatment of a number of diseases including COVID-19, hearing loss and bipolar disorder [22,23].…”