Organosilica nanoparticles containing sodium borocaptate (BSH) provide new prospects for boron neutron capture therapy (BNCT): efficient cellular uptake and enhanced BNCT efficacy

Laird, Mathilde; Matsumoto, Kotaro; Higashi, Yuya; Komatsu, Aoi; Raitano, Art; Morrison, Kendall; Suzuki, Minoru; Tamanoi, Fuyuhiko

doi:10.1039/d2na00839d

Cited by 10 publications

(6 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results indicated that modifying the SP94 peptide on nanoparticles could improve the targeting ability of tumor cells and realize the enrichment of 10 B in tumor cells to improve the therapeutic effect. Exposure to neutron irradiation can lead to changes in cell structure. , Obvious changes in the cell morphology after irradiation were observed (Figure f). We calculated the ratio of the long axis to the short axis of irradiated cells using ImageJ, and we found that the result of the SP94-LB@BA-MSN group was significantly different from the other groups, which means that this group had more changes in cell morphology (Figure S8).…”

Section: Resultsmentioning

confidence: 98%

“…Exposure to neutron irradiation can lead to changes in cell structure. 48,49 Obvious changes in the cell morphology after irradiation were observed (Figure 3f). We calculated the ratio of the long axis to the short axis of irradiated cells using ImageJ, and we found that the result of the SP94-LB@BA-MSN group was significantly different from the other groups, which means that this group had more changes in cell morphology (Figure S8).…”

Section: 3mentioning

confidence: 99%

See 1 more Smart Citation

Boron-Containing Mesoporous Silica Nanoparticles with Effective Delivery and Targeting of Liver Cancer Cells for Boron Neutron Capture Therapy

Tang,

Wang,

Hao

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 98%

Section: 3mentioning

confidence: 99%

Boron-Containing Mesoporous Silica Nanoparticles with Effective Delivery and Targeting of Liver Cancer Cells for Boron Neutron Capture Therapy

Tang,

Wang,

Hao

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…The peak around 759 cm −1 indicates the presence of the CTAB surfactant in Figure 2a [20]. The MSN framework appears at 632 cm −1 in both Figure 3a and Figure 3b [21].…”

Section: Raman Analysis Of Msn-ssmentioning

confidence: 91%

Disulfide-Modified Mesoporous Silica Nanoparticles for Biomedical Applications

Venedicto

Carrier

et al. 2023

Crystals

View full text Add to dashboard Cite

Mesoporous silica nanoparticles (MSNs) are highly porous carriers used in drug and gene delivery research for biomedical applications due to their high surface area, narrow particle size distribution, and low toxicity. Incorporating disulfide (SS) bonds into the walls of MSNs (MSN-SSs) offers a dual pathway for drug release due to the pore delivery and collapsing porous structure after cellular engulfment. This study explores the effect of embedding disulfide bonds into MSNs through various structural and biological characterization methods. Raman spectroscopy is employed to detect the SS bonds, SEM and TEM for morphology analyses, and a BET analysis to determine the required amount of SSs for achieving the largest surface area. The MSN-SSs are further loaded with doxorubicin, an anticancer drug, to assess drug release behavior under various pH conditions. The MSN-SS system demonstrated an efficient pH-responsive drug release, with over 65% of doxorubicin released under acidic conditions and over 15% released under neutral conditions. Cleaving the SS bonds using dithiothreitol increased the release to 94% in acidic conditions and 46% in neutral conditions. Biocompatibility studies were conducted using cancer cells to validate the engulfment of the nanoparticle. These results demonstrate that MSN-SS is a feasible nanocarrier for controlled-release drug delivery.

show abstract

“…BPA-loaded BPMO nanoparticles significantly accumulated in tumors and BNCT mediated by BPA-loaded BPMO demonstrated a significant tumor growth inhibition. Laird et al [ 72 ] used the same strategy, but loading BSH. This study was performed in human ovarian cancer spheroids.…”

Section: Bsh Bpa Gb-10 and Boric Acid: Brief History And Optimized De...mentioning

confidence: 99%

Optimizing Boron Neutron Capture Therapy (BNCT) to Treat Cancer: An Updated Review on the Latest Developments on Boron Compounds and Strategies

Hughes

2023

Cancers

View full text Add to dashboard Cite

Boron neutron capture therapy (BNCT) is a tumor-selective particle radiotherapy. It combines preferential boron accumulation in tumors and neutron irradiation. The recent initiation of BNCT clinical trials employing hospital-based accelerators rather than nuclear reactors as the neutron source will conceivably pave the way for new and more numerous clinical trials, leading up to much-needed randomized trials. In this context, it would be interesting to consider the implementation of new boron compounds and strategies that will significantly optimize BNCT. With this aim in mind, we analyzed, in this review, those articles published between 2020 and 2023 reporting new boron compounds and strategies that were proved therapeutically useful in in vitro and/or in vivo radiobiological studies, a critical step for translation to a clinical setting. We also explored new pathologies that could potentially be treated with BNCT and newly developed theranostic boron agents. All these radiobiological advances intend to solve those limitations and questions that arise during patient treatment in the clinical field, with BNCT and other therapies. In this sense, active communication between clinicians, radiobiologists, and all disciplines will improve BNCT for cancer patients, in a cost- and time-effective way.

show abstract

Organosilica nanoparticles containing sodium borocaptate (BSH) provide new prospects for boron neutron capture therapy (BNCT): efficient cellular uptake and enhanced BNCT efficacy

Abstract: Boron neutron capture therapy (BNCT), a method based on the fission of boron-10 upon neutron irradiation, has emerged as an attractive option for radiation therapy. To date, the main drugs...

Cited by 10 publications

References 60 publications

Boron-Containing Mesoporous Silica Nanoparticles with Effective Delivery and Targeting of Liver Cancer Cells for Boron Neutron Capture Therapy

Boron-Containing Mesoporous Silica Nanoparticles with Effective Delivery and Targeting of Liver Cancer Cells for Boron Neutron Capture Therapy

Disulfide-Modified Mesoporous Silica Nanoparticles for Biomedical Applications

Optimizing Boron Neutron Capture Therapy (BNCT) to Treat Cancer: An Updated Review on the Latest Developments on Boron Compounds and Strategies

Contact Info

Product

Resources

About