Organosilica Nanoparticles for Gemcitabine Monophosphate Delivery in Cancer Cells

Daurat, Morgane; Rahmani, Saher; Bouchal, Roza; Akrout, Alia; Budimir, Jelena; Nguyen, Christophe; Charnay, Clarence; Guari, Yannick; Richeter, Sébastien; Raehm, Laurence; Bettache, Nadir; Gary‐Bobo, Magali; Durand, Jean‐Olivier; Hesemann, Peter

doi:10.1002/cnma.201900202

Cited by 14 publications

(20 citation statements)

References 37 publications

(62 reference statements)

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“…In the 13 C CP-MAS analysis ( Figure 2 , left) we can identify the four different types of carbon centers at δ = 11.3, 17.4, 50.5 and 65.0 ppm, present in the molecular structure of 4 , corresponding to the bridging propyl units and the methyl group linked to the nitrogen center ( Scheme 1 b). These results indicate that no structural modification of the organic part of the silylated ammonium precursor occurred during the synthesis process, in agreement to our former works [ 25 , 26 , 29 , 30 ]. The 29 Si OP-MAS spectrum ( Figure 2 , right) indicates the presence of three types of silicon centers in the material: the T 1 band (δ = −49.5 ppm) stands for germinal silanol groups (R Si (OSi)(OH) 2 ), the T 2 band (δ = −58.5 ppm) for single silanols (R Si (OSi) 2 OH) and T 3 band (δ = −67.5 ppm) can be attributed to fully condensed organosilica centers (R Si (OSi) 3 ).…”

Section: Resultssupporting

confidence: 93%

“…Here, we have investigated for the first time ionosilica hydrogels as draw solutes in FO. As a silica-supported form of ionic liquids, ionosilicas recently appeared as highly polyvalent materials with high potential for applications in separation [ 19 , 20 , 21 , 22 ], catalysis [ 23 , 24 ] and drug delivery [ 25 , 26 ]. The high hydrophilicity of ionosilicas was monitored via solvent adsorption measurements [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

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Quaternary Ammonium-Based Ionosilica Hydrogels as Draw Solutes in Forward Osmosis

Rodrigues

Jacob²,

Gauchou³

et al. 2020

Molecules

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In the last few years, forward osmosis (FO) has attracted increasing interest as a sustainable technique for water desalination and wastewater treatment. However, FO remains as an immature process principally due to the lack of efficient and easily recyclable draw solutes. In this work, we report that ionosilica hydrogels based on quaternary ammonium halide ionosilica are efficient draw solutes in FO. Fluidic ionosilica hydrogels were obtained via hydrolysis-polycondensation reactions of a trisilylated quaternary ammonium precursor in slightly acidic water/ethanol solvent mixtures. The liquid-to-gel transition of the precursor and the kinetics of the formation of hydrogels were monitored by liquid NMR measurements. The formed hydrogels were shown to generate osmotic pressure up to 10.0 atm, indicating the potential of these hydrogels as efficient draw solutes in FO. Our results suggest that iodide anions are the osmotically active species in the system. Regeneration of the hydrogels via ultrafiltration (UF) was successfully achieved, allowing the development of a closed FO-UF process. However, the osmotic performances of the ionosilica hydrogels irreversibly decreased along the successive FO-UF cycles, probably due to anion exchange processes.

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Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Quaternary Ammonium-Based Ionosilica Hydrogels as Draw Solutes in Forward Osmosis

Rodrigues

Jacob²,

Gauchou³

et al. 2020

Molecules

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“…We already reported ionosilica nanoparticles (INPs), obtained following modified Stöbertechniques. In our previous studies, we used ionosilica nanoparticles as drug carrier vehicles for anionic drugs [32,33]. In this way, we took benefit of the unique anion exchange properties of ionosilicas [23,[34][35][36][37], combined with the possibility to efficiently control the morphology of silica hybrid materials.…”

Section: Figure 1 Chemical Constitution Of An Ionosilicamentioning

confidence: 99%

Controlled synthesis and osmotic properties of ionosilica nanoparticles

Rodrigues

Jacob²,

Gauchou³

et al. 2021

Microporous and Mesoporous Materials

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Ionosilica nanoparticles are original ionic nano-objects at the interface of ionic liquids and mesoporous silica. Ionosilica nanoparticles' synthesis was achieved via sol-gel procedures exclusively from ionic trialkoxysilylated precursors without any silica source. However, the knowledge about the main synthesis parameters for a controlled synthesis of ionosilica nanoparticles remained fragmental so far. In this work, we present a systematic study for ionosilica nanoparticle formation starting from a virtually cationic silylated ammonium precursor. Due to their ionic nature, the behavior of ionic precursors considerably differs from that of conventional molecular silylated precursors. Here, we screened several reaction parameters for ionosilica nanoparticles' formation such as solvent polarity, precursor and surfactant concentrations, and temperature. Our results allow controlling the textures and architectures of ionosilica nanoparticles in terms of porosity (specific surface area) and particle size. The formed ionosilica nanoparticles were thoroughly characterized by means of nitrogen sorption, elemental analysis, electron microscopies, dynamic light scattering (DLS), and solid state NMR measurements. Liquid 1 H-NMR spectroscopic measurements allowed monitoring the kinetics of the hydrolysis-polycondensation reactions. It appeared that the hydrolysis is relatively fast (30-120 min) whereas the polycondensation reaction requires more time (1-2 days).Finally, we used Forward Osmosis (FO-) experiments as a valuable tool to monitor a possible evolution of the nanoparticles in aqueous media. We observed that the ionosilica nanoparticles showed decreasing osmotic properties in successive FO-regeneration cycles. We attribute these results either to the exchange of the osmotically active halide anions or to particle agglomeration.Ionosilica nanoparticles therefore show limited long-term stability in aqueous media that limit their potential as draw solute in forward osmosis.

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“…The release of GMP was dependent on a low pH. The nanoparticles were endocytosed by MCF-7 breast cancer cells and were efficient in causing cancer cell death [53].…”

Section: Ph or Enzyme Responsive Systemsmentioning

confidence: 99%

Recent Development to Explore the Use of Biodegradable Periodic Mesoporous Organosilica (BPMO) Nanomaterials for Cancer Therapy

Chinnathambi

Tamanoi

2020

Pharmaceutics

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Porous nanomaterials can be used to load various anti-cancer drugs efficiently and deliver them to a particular location in the body with minimal toxicity. Biodegradable periodic mesoporous organosilica nanoparticles (BPMOs) have recently emerged as promising candidates for disease targeting and drug delivery. They have a large functional surface and well-defined pores with a biodegradable organic group framework. Multiple biodegradation methods have been explored, such as the use of redox, pH, enzymatic activity, and light. Various drug delivery systems using BPMO have been developed. This review describes recent advances in the biomedical application of BPMOs.

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Organosilica Nanoparticles for Gemcitabine Monophosphate Delivery in Cancer Cells

Cited by 14 publications

References 37 publications

Quaternary Ammonium-Based Ionosilica Hydrogels as Draw Solutes in Forward Osmosis

Quaternary Ammonium-Based Ionosilica Hydrogels as Draw Solutes in Forward Osmosis

Controlled synthesis and osmotic properties of ionosilica nanoparticles

Recent Development to Explore the Use of Biodegradable Periodic Mesoporous Organosilica (BPMO) Nanomaterials for Cancer Therapy

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