Organotin and organochlorine toxicants activate key translational regulatory proteins in human immune cells

Ruff, Amanda; Lewis, Meaghan M.; Whalen, Margaret M.

doi:10.1007/s00204-022-03413-z

Cited by 4 publications

(1 citation statement)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, in PBMCs and in the same concentrations of TBT (ranging from 2.5 to 200 nM) with varying in vitro exposures of 10 min, 1, 6 and 24 h, TBT induced the activation or increased expression levels of ribosomal protein S6 (S6), eukaryotic initiation factor 4B (eIF4B) and eIF4E in these cells. Surprisingly, this activation or elevation occurred at concentrations known to induce pro-inflammatory cytokine production, despite the absence of concomitant mRNA upregulation for these proteins [ 88 ]. Specifically, in monocyte-free human PBMCs, in addition to an increase in IL-1β synthesis and secretion, an increase in IL-6 synthesis and secretion was observed using the same concentrations of TBT [ 89 , 90 ].…”

Section: Tbt and The Immune Systemmentioning

confidence: 99%

Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin

Teixeira

Paiva

Miranda-Alves

2023

Toxics

View full text Add to dashboard Cite

Tributyltin (TBT) is an environmental contaminant present on all continents, including Antarctica, with a potent biocidal action. Its use began to be intensified during the 1960s. It was effectively banned in 2003 but remains in the environment to this day due to several factors that increase its half-life and its misuse despite the bans. In addition to the endocrine-disrupting effect of TBT, which may lead to imposex induction in some invertebrate species, there are several studies that demonstrate that TBT also has an immunotoxic effect. The immunotoxic effects that have been observed experimentally in vertebrates using in vitro and in vivo models involve different mechanisms; mainly, there are alterations in the expression and/or secretion of cytokines. In this review, we summarize and update the literature on the impacts of TBT on the immune system, and we discuss issues that still need to be explored to fill the knowledge gaps regarding the impact of this endocrine-disrupting chemical on immune system homeostasis.

show abstract

Section: Tbt and The Immune Systemmentioning

confidence: 99%

Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin

Teixeira

Paiva

Miranda-Alves

2023

Toxics

View full text Add to dashboard Cite

show abstract

Flame retardant, hexabromocyclododecane, increases production of pro‐inflammatory cytokines, interleukin 1‐beta and interleukin 6, in human immune cells

Falconer‐Turner,

Brooks,

Ogaga

et al. 2024

J of Applied Toxicology

View full text Add to dashboard Cite

Hexabromocyclododecane (HBCD) is an environmental contaminant due to its use as a flame retardant in a variety of applications ranging from building insulation, furniture upholstery, and housing for appliances and electronics. HBCD is found in wildlife, human breastmilk, and serum. Interleukin 1‐beta (IL‐1β) and interleukin 6 (IL‐6) are pro‐inflammatory cytokines, whose dysregulation is associated with chronic inflammation and the pathologies that result, such as tumor growth, rheumatoid arthritis, Crohn's disease, and multiple sclerosis. HBCD has been shown to increase the secretion of both IL‐1β and IL‐6 from human immune cells. However, it is not clear if these increases are due solely to HBCD effects on the secretory process or whether it is stimulating cellular production of IL‐1β and IL‐6. This study examines if HBCD can increase the production of IL‐1β and IL‐6 by immune cells by simultaneously assessing secreted levels and cellular levels of these cytokines. Additionally, the mechanisms for any observed changes in production are investigated. Peripheral blood mononuclear cells were exposed to HBCD over a range of concentrations and lengths of exposure. HBCD was found to stimulate IL‐1β and IL‐6 production after 6 hrs. of exposure and production was sustained and intensified at 24 hrs. This increase in IL‐1β and IL‐6 production appears to, in part, be a result of increased mRNA expression. Additionally, the MAPK pathways, specifically the p38 and p44/42 pathways, appear to be required for HBCD‐induced increases in IL‐1β and IL‐6 production.

show abstract

Interleukin 1β and interleukin 6 production in human immune cells is stimulated by the antibacterial compound Triclosan

Wilburn,

Gabure,

Whalen

2023

Arch Toxicol

View full text Add to dashboard Cite

Organotin and organochlorine toxicants activate key translational regulatory proteins in human immune cells

Cited by 4 publications

References 39 publications

Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin

Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin

Flame retardant, hexabromocyclododecane, increases production of pro‐inflammatory cytokines, interleukin 1‐beta and interleukin 6, in human immune cells

Interleukin 1β and interleukin 6 production in human immune cells is stimulated by the antibacterial compound Triclosan

Contact Info

Product

Resources

About