Organotin esters of 3-(2-furanyl)-2-propenoic acid: their characterization and biological activity

Danish, Muhammad; Alt, Helmut G.; Badshah, Amin; Ali, Saqib; Mazhar, Muhammad; Nazar-ul-Islam,

doi:10.1016/0022-328x(94)05050-l

Cited by 74 publications

(36 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cumulative effect of these two highly electronegative groups on tin increases its Lewis acidity, which facilitates chelation through the carbonyl oxygen and results in a change in the geometry from tetrahedral to trigonal bipyramidal. Thus, an increase in the [2,3]. This is observed in the derivatives where R‫ס‬Me or Et (Tables 1 and 3), in agreement with the trigonal bipyramidal geometry due to the bidentate chelate carboxylate group.…”

Section: Nmr Spectroscopysupporting

confidence: 84%

“…119/117 Sn-13 C]| spin-spin coupling for R 3 SnL derivatives is usually less than 400 Hz and about 650 Hz for alkyl and aryl R groups, respectively [2,3]. In the present series, these values are in the range of 500-576 Hz for alkyl groups, while, for aryl groups, these coupling constants could not be observed.…”

Section: J[contrasting

confidence: 63%

“…In the present series, these values are in the range of 500-576 Hz for alkyl groups, while, for aryl groups, these coupling constants could not be observed. It has been re- (Tables 2 and 5), in comparison with their triorganotin analogues [2,3], also proves the increase in the coordination number of the tin atom [11,12]. However, the 119 Sn NMR resonance signals of these compounds are rather broad as compared to those of triorganotin carboxylates, in agreement with the dynamic process involving the carboxylate oxygens. ]…”

Section: J[mentioning

confidence: 74%

“…Previously, we have synthesized and characterized organotin carboxylates of the general formulas R 3 SnL, R 2 SnL 2 , and [(R 2 SnL) 2 O] 2 using either an organotin chloride or an organotin oxide as one of the starting materials [2][3][4][5]. In this article, we report the *Author to whom correspondence should be addressed.…”

Section: Introductionmentioning

confidence: 97%

See 3 more Smart Citations

Redistribution reactions of diorganotin dicarboxylates and diorganotin dihalides: A convenient method for the preparation of halo-diorganotin carboxylates

1997

Self Cite

View full text Add to dashboard Cite

Organotin compounds with the general formula R2(X)SnL (where R=Me, Et, n‐Bu, Ph; L=the trans‐3‐(2‐furanyl)‐2‐propenoate anion or the trans‐3‐(3‐methylphenyl)‐2‐propenoate anion; and X=Cl) have been prepared by redistribution reactions between the R2SnL2 and R2SnX2 compounds. These compounds were characterized by elemental analyses and various spectroscopic techniques such as 1H, 13C, 119Sn NMR, Mass, Mössbauer, and IR spectroscopies. On the basis of these spectroscopic data, it is suggested that these compounds adopt the cis‐R2(X)SnO2 geometry. © 1997 John Wiley & Sons, Inc. Heteroatom Chem 8: 273–278, 1997.

show abstract

Section: Nmr Spectroscopysupporting

confidence: 84%

Section: J[contrasting

confidence: 63%

Section: J[mentioning

confidence: 74%

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Redistribution reactions of diorganotin dicarboxylates and diorganotin dihalides: A convenient method for the preparation of halo-diorganotin carboxylates

1997

Self Cite

View full text Add to dashboard Cite

show abstract

“…Different mono-, di-and triorganotin (IV) carboxylates were prepared by treating the corresponding ligand acid with organotin oxide/hydroxides or its sodium salt with organotin chlorides, adopting various standard procedures [28].…”

Section: Synthesismentioning

confidence: 99%

Synthesis, Chemical Characterization and Biological Screening for Cytotoxicity and Antitumor Activity of Organotin (IV) Derivatives of 3,4-Methylenedioxy 6-nitrophenylpropenoic Acid

et al. 2007

Self Cite

View full text Add to dashboard Cite

A series of mono-, di-and triorganotin compounds with general formulae [RSnL 2 Cl], R = Bu (compound 3), [R 2 SnL 2 ], where R = Me, Et, Bu, Oct (compounds 1, 2, 4 and 6) and [R 3 SnL], where R = Bu, Cy and Ph (compounds 5, 7 and 8) and where L = 3,4-methylenedioxy-6-nitrophenylpropenoic acid have been prepared and characterized by elemental analysis, multinuclear ( 1 H-, 13 C-and 119 Sn-) NMR and mass spectrometry. The ligand and its respective organotin complexes were screened for cytotoxicity using the brine shrimp lethality assay and for antitumor activity using the crown gall tumor inhibition (potato disc) assay. The bioassay results support the conclusion that the biological activities of these synthetic compounds are in the following order: [RSnL 2 Cl] < [R 2 SnL 2 ] < [R 3 SnL].

show abstract

Fluxional behavior in dimeric tetraorganodicarboxylato stannoxanes

1996

Self Cite

View full text Add to dashboard Cite

The mechanism of the fluxional process occurring in dimeric tetraorganodicarboxylato stannoxanes is presented on the basis of multinuclear NMR studies carried out in noncoordinating solvents. This fluxional process is a consequence of rapid migration of carboxylate groups from one tin atom to the other. It has been proposed that larger carboxylates will also execute this behavior. The effect of cis and trans positions on the fluxional process is discussed. The fluxional process is very fast and could not be stopped even at low temperatures, as measured on the NMR time scale. © 1996 John Wiley & Sons, Inc.

show abstract

Organotin esters of 3-(2-furanyl)-2-propenoic acid: their characterization and biological activity

Cited by 74 publications

References 22 publications

Redistribution reactions of diorganotin dicarboxylates and diorganotin dihalides: A convenient method for the preparation of halo-diorganotin carboxylates

Redistribution reactions of diorganotin dicarboxylates and diorganotin dihalides: A convenient method for the preparation of halo-diorganotin carboxylates

Synthesis, Chemical Characterization and Biological Screening for Cytotoxicity and Antitumor Activity of Organotin (IV) Derivatives of 3,4-Methylenedioxy 6-nitrophenylpropenoic Acid

Fluxional behavior in dimeric tetraorganodicarboxylato stannoxanes

Contact Info

Product

Resources

About