Organotin Implications in Anticarcinogenesis. Background and Thymus Involvement

Abstract

Summary, A comprehensive study of the scientific literature regarding tin content in normal and pathogenii; himiiin tissue has disclosed that various organotin materials retard both the onset and growth of cancer in laboratory animals, and decreased tissue tin in humans may be associated with lumour development.Initial studies by the authors have shown that the thymus gland of the mouse possesses a relatively high concentr;ition of tin and is also the major site of accumulation for I'C-labelied tri-n-biityltin fluoride (TBTF), When mammary cancer-prone mice with transplanted tumours were orally dosed continuously with this agent in their drinking water, the tumour growth rate was significantly reduced. Both mouse mammary tumours and human lung tumours show low tin contenl compared to normal body tissue.

In vitro cytotoxic activity of tri-n-butyltin(IV)lupinylsulfide hydrogen fumarate (IST-FS 35) and preliminary antitumor activity in vivo

“…During the last two decades, they have caught much attention for their potential biocidal activities and, in recent years, several organotin compounds have been synthesized, some with interesting in vitro cytotoxic activity [17]. Such activity, often revealed higher than that of cisplatin and sometimes …”

“…A huge number of tin derivatives have been prepared and tested in the past as possible antitumor agents [17][18][19] and many of them exhibited interesting activity in specific cancer models, but they lacked activity against a broad spectrum of experimental tumors [1].…”

A New Bis(dithioester): Methanediyl Bis(N,N-diethyldithiocarbamate), Derived fromcis-Dichlorobis(N,N-diethyldithiocarbamato-S,S')tin(IV)

“…The interest in (1). whose molecular structure is already known (Bohra et al, 1994;Selvaraju et al, 1994), is due to its antitumor activity (Smith, 1978;, Cardarelli & Libby, 1984. Then, during reactivity studies of (1) with 2-thiouracil [which exhibits a marked affinity for melanin-producing tissue (W~itjen et al, 1982)], we unexpectedly obtained white crystals of the title compound, (2), identified as methanediyl bis(N,N'-diethyldithiocarbamate) by X-ray structure and IR spectroscopic analysis.…”