Organotin(IV) tryptophanylglycinates: potential non‐steroidal antiinflammatory agents; crystal structure of dibutyltin(IV) tryptophanylglycinate

Nath, Mala; Singh, Himanshu; Kumar, Puneet; Kumar, Ashok; Song, Xueqing; Eng, George

doi:10.1002/aoc.1514

Cited by 25 publications

(19 citation statements)

References 69 publications

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“…The appearance of such peaks provides further evidence for the coordination between ligand and Sn(IV). The coordination thus takes place between the tin atom and a secondary amine, carboxylate and alkyl or phenyl groups [34,35].…”

Section: Infrared Spectroscopymentioning

confidence: 99%

Photostabilizing Efficiency of Poly(vinyl chloride) in the Presence of Organotin(IV) Complexes as Photostabilizers

2016

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Three organotin complexes containing furosemide as a ligand (L), Ph 3 SnL, Me 2 SnL 2 and Bu 2 SnL 2 , were synthesized and characterized. Octahedral geometry was proposed for the Me 2 SnL 2 and Bu 2 SnL 2 , while the Ph 3 SnL complex has trigonal bipyramid geometry. The synthesized organotin complexes (0.5% by weight) were used as additives to improve the photostability of poly(vinyl chloride), PVC, (40 µm thickness) upon irradiation. The changes imposed on functional groups, weight loss and viscosity average molecular weight of PVC films were monitored. The experimental results show that the rate of photodegradation was reduced in the presence of the organotin additives. The quantum yield of the chain scission was found to be low (9.8 × 10 −7 ) when Ph 3 SnL was used as a PVC photostabilizer compared to controlled PVC (5.18 × 10 −6 ). In addition, the atomic force microscope images for the PVC films containing Ph 3 SnL 2 after irradiation shows a smooth surface compared to the controlled films. The rate of PVC photostabilization was found to be highest for Ph 3 SnL followed by Bu 2 SnL 2 and Me 2 SnL 2 . It has been suggested that the organotin complexes could act as hydrogen chloride scavengers, ultraviolet absorbers, peroxide decomposers and/or radical scavengers.

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Section: Infrared Spectroscopymentioning

confidence: 99%

Photostabilizing Efficiency of Poly(vinyl chloride) in the Presence of Organotin(IV) Complexes as Photostabilizers

2016

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“…This promising finding was suggesting a possible use of triazolopyrimidines derivatives as leads for a potential field of novel therapeutic options able to overcome the antibiotic resistant strains which prompted us to undertake the present study by evaluating the change of activity associated with the introduction on the basic heterocycle of different radical groups giving non classical isosteric ligands, expected to be endowed with better hydrophobicity. Besides, organotins are known to possess, per se, antitumour [10,11], antimicrobial [12] and anti-inflammatory [13] activities; triazolopyrimidines complexes with several divalent metal ions have been tested as inhibitors of the growth of different Gram(+) and Gram(−) bacteria [12]. In particular, recent findings on compounds of metal ions (Co(II), Cu(II), Ni(II)) with closely related ligands, have proven to be effective antiparasital agents against Trypanosoma cruzi [14] and to be endowed with antiproliferative in vitro activity against Leishmania spp.…”

mentioning

confidence: 99%

Synthesis, characterization, crystal structures and in vitro antistaphylococcal activity of organotin(IV) derivatives with 5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidine

Girasolo

Canfora

Sabatino

et al. 2012

Journal of Inorganic Biochemistry

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New organotin(IV) complexes of 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine (dbtp) and 5,7-diphenyl-1,2,4-triazolo [1,5-a]pyrimidine (dptp) with 1:1 and/or 1:2 stoichiometry were synthesized and investigated by X-ray diffraction, Sn Mössbauer in the solid state and by 1 H and 13 C NMR spectroscopy, in solution. Moreover, the crystal and molecular structures of Et 2 SnCl 2 (dbtp) 2 and Ph 2 SnCl 2 (EtOH) 2 (dptp) 2 are reported. The complexes contain hexacoordinated tin atoms: in Et 2 SnCl 2 (dbtp) 2 two 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine molecules coordinate classically the tin atom through N(3) atom and the coordination around the tin atom shows a skew trapezoidal structure with axial ethyl groups. In Ph 2 SnCl 2 (EtOH) 2 (dptp) 2 two ethanol molecules coordinate tin through the oxygen atom and the 5,7-diphenyl-1,2,4-triazolo [1,5-a]pyrimidine molecules are not directly bound to the metal center but strictly H-bonded, through N (3), to the \OH group of the ethanol moieties; Ph 2 SnCl 2 (EtOH) 2 (dptp) 2 has an all-trans structure and the C-Sn-C fragment is linear. On the basis of Mössbauer data, the 1:2 diorganotin(IV) complexes are advanced to have the same structure of Et 2 SnCl 2 (dbtp) 2 , while Me 2 SnCl 2 (dptp) 2 to have a regular all-trans octahedral structure. A distorted cis-R 2 trigonal bipyramidal structure is assigned to 1:1 diorganotin(IV) complexes. The in vitro antibacterial activities of the synthesized complexes have been tested against a group of reference pathogen micro-organisms and some of them resulted active with MIC values of 5 μg/mL, most of all against staphylococcal strains, which shows their inhibitory effect.

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“…Considerable efforts have been made to understand the binding mode of organotin compounds with biologically relevant ligands such as amino acids [11]- [14] and dipeptides [15], [16] which constitute a very important class of biomolecules.…”

Section: Introductionmentioning

confidence: 99%

Equilibrium Studies on Interaction of Organotin (IV) Moieties with N-O Donor Ligands

2015

IJSR

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Organotin(IV) tryptophanylglycinates: potential non‐steroidal antiinflammatory agents; crystal structure of dibutyltin(IV) tryptophanylglycinate

Abstract: Diorganotin(IV) derivatives of tryptophanylglycine (H 2Trp

Cited by 25 publications

References 69 publications

Photostabilizing Efficiency of Poly(vinyl chloride) in the Presence of Organotin(IV) Complexes as Photostabilizers

Photostabilizing Efficiency of Poly(vinyl chloride) in the Presence of Organotin(IV) Complexes as Photostabilizers

Synthesis, characterization, crystal structures and in vitro antistaphylococcal activity of organotin(IV) derivatives with 5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidine

Equilibrium Studies on Interaction of Organotin (IV) Moieties with N-O Donor Ligands

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