Organotins in fish muscle and liver from the Polish coast of the Baltic Sea: Is the total ban successful?

Filipkowska, Anna; Złoch, Ilona; Wawrzyniak-Wydrowska, Brygida; Kowalewska, Grażyna

doi:10.1016/j.marpolbul.2016.06.052

Cited by 29 publications

(19 citation statements)

References 23 publications

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“…While phenyltins exhibited an increasing temporal trend and the highest median value for butyltins was observed in 2015. High imposex frequency and OTC residues were also observed in recent studies in the Mediterranean, the Atlantic and the Polish coast of the Baltic sea [33,34]. These findings were not surprised since the long-term preservation of OTCs in sediments and the possibility of their illegal usage [14].…”

Section: Temporal Variation Of Organotinssupporting

confidence: 64%

Spatiotemporal variation and source apportionment of organotin compounds in sediments in the Yangtze Estuary

et al. 2019

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Background: The Yangtze Estuary is a vital habitat and breeding ground for many rare species (e.g., Chinese sturgeon, Chinese paddlefish). From the view of marine ecosystem health, organotin compounds (OTCs) should be of great concern in this area based on their broad applications and potential threats. At present study, five OTC species were determined in 28 and 26 surface sediments from the Yangtze Estuary (including the Nearshore area, Estuarine Turbidity Maxima (ETM) zone and Plume zone) in 2015 and 2016, respectively. Meanwhile, four sludge samples were collected from the adjacent Shidongkou Wastewater Treatment Plant to perform a source apportionment. Results: The sum of OTCs presented a decreasing trend towards the open sea, averaging 4.8 ± 6.0 ng Sn g −1 dw in the Plume zone. While OTC levels in the Nearshore area (2.9-34.6 ng Sn g −1 dw) were similar with those in the ETM zone (5.6-36.0 ng Sn g −1 dw), and the sites belonging to the Deepwater Navigation Channel showed heavier contamination in the ETM zone than the Nearshore area. There are abundant suspended particles and organic matters in the ETM zone that can effectively capture the hydrophobic compounds. Besides, OTC contamination in shoreside zone was more serious than those in channel center. High OTC loads (average 633 ± 124 ng Sn g −1 dw) were also found in sludge samples from adjacent wastewater treatment plant. Conclusion: Land-based sources (e.g. sewage discharge, runoff) are probably one of the predominant pathways of OTCs entering the ocean. Combining with previous observation in 2014, OTC contamination in the same ten sites varied slightly with years. Risk assessment indicated that the concentrations of tributyltin (TBT) are sufficient to pose ecosystem threats especially in the ETM zone. Hence, OTC contamination issues in the Yangtze Estuary still can not be neglected.

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Section: Temporal Variation Of Organotinssupporting

confidence: 64%

Spatiotemporal variation and source apportionment of organotin compounds in sediments in the Yangtze Estuary

et al. 2019

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“…Tributyltin is recognized worldwide as an endocrine disruptor, being associated with the imposex phenomenon on female dogwhelks and shell thickening on oysters during the 1980s (Lintelmann et al, 2003). Several scientists around the word are wondering if the total ban has been successful (Anastasiou et al, 2016;Batista et al, 2016;Filipkowska et al, 2016). Nevertheless, sixty-two years following their first application and 9 years after the complete ban on their use as biocides in 2003(EC No.…”

Section: Environmental Concernmentioning

confidence: 99%

“…Imposex in gastropods (Acanthina monodon, Oliva peruviana and Xanthochorus cassidiformis) has been reported by Batista et al, (2016) in three areas along the central Chilean coast. Filipkowska et al, (2016) analysed muscle and liver tissues of nine fish species reporting maximum total concentrations of butyltin compounds (BTs) of 715 and 1132 ng g −1 d.w. of Sn, respectively. Results demonstrate that butyltins are still present in fish from the Polish coast of the Baltic Sea.…”

Section: Environmental Concernmentioning

confidence: 99%

Organotin compounds in marine sediment: Detection and concerns

2018

Global NEST Journal

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The determination of organotin compounds (OTCs) in environmental matrices has been subject to great scientific attention during last years, as the accuracy and sensitivity of analytical methods need to be improved in order to be able to detect the compounds of interest in a complex matrix such as sediment. The European Union Water Framework Directive (2013/39/EU) sets very restrictive environmental quality standards for 45 priority substances and other pollutants, including OTCs. Therefore, it is necessary to develop analytical methods in compliance with the environmental quality standard (EQSs) proposed to protect the aquatic environment and human beings. So far various analytical procedures have been used, including gas chromatographic analyses. Most of these methods comprise different steps such as extraction, derivatisation, clean up and the use of several sophisticated instrumentations, as well. Among them the conversion of tributyltin into Sn to allow its determination by Atomic Absorption Spectrometry or Anodic Stripping Voltammetry (AVS) has also been attempted. A great number of studies have been performed on OTCs analysis in marine sediment. However, the only review available in literature discussing the upgrades of analytical methods is dated back to 1997. We reviewed the analytical procedures and discussed them comparatively in order to identify the current state-of-theart in OTCs detection. Finally, environmental concerns about OTCs were discussed.

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“…TBT is an organotin with many industrial applications including use in polyvinyl chloride (PVC) catalysts, broad-spectrum biocides, agricultural fungicides, construction materials, wood and textile preservatives, and antifouling agents for marine vessels (Fent 1996;U.S. EPA 2003;Fromme et al 2005;Kannan et al 2010).…”

Section: Introductionmentioning

confidence: 99%

“…EPA 2003;Fromme et al 2005;Kannan et al 2010). The major route of human TBT exposure is reported to be via ingestion of contaminated water and food, specifically seafood (Azenha and Vasconcelos 2002;Chien et al 2002;Antizar-Ladislao 2008;Airaksinen et al 2010;Jadhav et al 2011;Kucuksezgin et al 2011;Filipkowska et al 2016;Ashraf et al 2017). In the 1960s, widespread use of TBT as an antifouling agent began, but after discovering detrimental effects…”

Section: Introductionmentioning

confidence: 99%

Hepatic Tumor Formation in Adult Mice Developmentally Exposed to Organotin

Katz

Grimm

Kaushal

et al. 2020

Environ Health Perspect

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BACKGROUND: Tributyltin (TBT) is a persistent and bioaccumulative environmental toxicant. Developmental exposure to TBT has been shown to cause fatty liver disease (steatosis), as well as increased adiposity in many species, leading to its characterization as an obesogen. OBJECTIVE: We aimed to determine the long-term effects of developmental TBT exposure on the liver. METHODS: C57BL/6J mice were exposed to a dose of TBT (0:5 mg=kg body weight per day; 3:07 lM) below the current developmental no observed adverse effect level (NOAEL) via drinking water, or drinking water alone, provided to the dam from preconception through lactation. Sires were exposed during breeding and lactation. Pups from two parity cycles were included in this study. Animals were followed longitudinally, and livers of offspring were analyzed by pathological evaluation, immunohistochemistry, immunoblotting, and RNA sequencing. RESULTS: Developmental exposure to TBT led to increased adiposity and hepatic steatosis at 14 and 20 weeks of age and increased liver adenomas at 45 weeks of age in male offspring. Female offspring displayed increased adiposity as compared with males, but TBT did not lead to an increase in fatty liver or tumor development in female offspring. Liver tumors in male mice were enriched in pathways and gene signatures associated with human and rodent nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC). This includes down-regulation of growth hormone receptor (GHR) and of STAT5 signaling, which occurred in response to TBT exposure and preceded liver tumor development. CONCLUSIONS: These data reveal a previously unappreciated ability of TBT to increase risk for liver tumorigenesis in mice in a sex-specific manner. Taken together, these findings provide new insights into how early life environmental exposures contribute to liver disease in adulthood.

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Organotins in fish muscle and liver from the Polish coast of the Baltic Sea: Is the total ban successful?

Cited by 29 publications

References 23 publications

Spatiotemporal variation and source apportionment of organotin compounds in sediments in the Yangtze Estuary

Spatiotemporal variation and source apportionment of organotin compounds in sediments in the Yangtze Estuary

Organotin compounds in marine sediment: Detection and concerns

Hepatic Tumor Formation in Adult Mice Developmentally Exposed to Organotin

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