Organs at risk dose constraints in carbon ion radiotherapy at MedAustron: Translations between LEM and MKM RBE models and preliminary clinical results

Grosshagauer, Sarah; Fossati, Piero; Schafasand, Mansure; Carlino, A.; Poljanc, Karin; Radakovits, Tobias; Hug, Eugen B.; Georg, Petra; Pelak, M.; Góra, J.

doi:10.1016/j.radonc.2022.08.008

Cited by 11 publications

(14 citation statements)

References 25 publications

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“…Even if the dose is corrected, there might be physical dose variations due to different clinical dose optimization algorithms and delivery techniques 46 . Current studies on the conversion of Japanese constraints to LEM‐based constraints are limited 15,46–52 . One study produced a dose translation model to convert brainstem constraints from the Japanese model to the LEM.…”

Section: Discussionmentioning

confidence: 99%

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Dose–volume constraints for head‐and‐neck cancer in carbon ion radiotherapy: A literature review

et al. 2023

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Head-and-neck (HN) tumors are ranked as the sixth most common malignancy worldwide. Treatment options depend on the stage, anatomical site, and surgical accessibility of the HN tumors. 1 Depending on the stage, squamous cell carcinomas (SCCs) can be treated with surgery, radiotherapy, or a combination of surgery, radiotherapy, and/ or chemotherapy. On the other hand, non-SCCs, being usually resistant to chemotherapy and radiotherapy, have limited treatment options. 2 Carbon ion radiotherapy (CIRT) has various advantages compared with X-ray radiotherapy (XRT). It has higher biological effectiveness than XRT and has already shown promising results for the treatment of resistant tumors like sarcoma, adenocarcinoma, and other non-SCCs. [3][4][5]

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Section: Discussionmentioning

confidence: 99%

“… 46 Current studies on the conversion of Japanese constraints to LEM‐based constraints are limited. 15 , 46 , 47 , 48 , 49 , 50 , 51 , 52 One study produced a dose translation model to convert brainstem constraints from the Japanese model to the LEM. Japanese and LEM‐based treatment plans were designed.…”

Section: Discussionmentioning

confidence: 99%

Dose–volume constraints for head‐and‐neck cancer in carbon ion radiotherapy: A literature review

et al. 2023

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“…RBE is affected by numerous factors, including measured endpoint, dose, dose rate, dose per fractionation, number of fractions, particle charge and velocity, oxygen concentration, and cell-cycle phase. While biophysical models such as the local effect model (LEM) or microdosimetric kinetic model (MKM) are used to determine the RBE of CIRT, theoretical modeling of the biological effects of heavy ions remains a challenging task due to the complexity and limited knowledge of the physical, chemical, and biological processes involved [ 47 ]. Despite CIRT’s successful application for several decades in the real world, research on these biophysical models continues to be an active area of investigation [ 48 ].…”

Section: Limitations Of Cirt In Hccmentioning

confidence: 99%

Carbon Ion Radiotherapy in the Treatment of Hepatocellular Carcinoma

Byun,

Kim,

Seong

2023

Clin Mol Hepatol

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Hepatocellular carcinoma (HCC) is a highly lethal cancer with limited treatment options and poor prognosis. Carbon ion radiotherapy (CIRT) has emerged as a promising treatment modality for HCC due to its unique physical and biological properties. CIRT uses carbon ions to target and destroy cancer cells with a high precision and efficacy. The Bragg Peak phenomenon allows precise dose delivery to the tumor while minimizing damage to healthy tissues. In addition, the high relative biological effectiveness of carbon ions can be shown against radioresistant and hypoxic tumor areas. CIRT also offers a shorter treatment schedule than conventional radiotherapy, which increases patient convenience and compliance. The clinical outcomes of CIRT for HCC have shown excellent local control rates with minimal side effects. Considering its physical and biological properties, CIRT may be a viable option for complex clinical scenarios such as patients with poor liver function, large tumors, re-irradiation cases, and tumors close to critical organs. Further research and larger studies are needed to establish definitive indications for CIRT and to compare its efficacy with that of other treatment modalities. Nevertheless, CIRT offers a potential breakthrough in HCC management, providing hope for improved therapeutic outcomes and reduced treatment-related toxicities.

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“…European centres have mainly used the local effect model (LEM), developed by the first German CIRT centre (the Helmholtz Center for Heavy Ion Research (GSI), Darmstadt) 76–78 . The models can give different values of RBE and biologically equivalent doses, and between different model versions as they evolve with time, leading to work on translating between the approaches 37,69,78–81 and to recommendations for international standardisation of reporting ion doses 37 . However, this uncertainty requires care in comparing clinical doses and outcomes between centres and clinical trials and in transferring experience between the different systems 31,36,37,56,79,82 …”

Section: Why Ions Heavier Than Protons and Why Carbon Ions?mentioning

confidence: 99%

The rationale for a carbon ion radiation therapy facility in Australia

Thwaites,

Prokopovich,

Garrett

et al. 2023

J of Medical Radiation Sci

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Australia has taken a collaborative nationally networked approach to achieve particle therapy capability. This supports the under‐construction proton therapy facility in Adelaide, other potential proton centres and an under‐evaluation proposal for a hybrid carbon ion and proton centre in western Sydney. A wide‐ranging overview is presented of the rationale for carbon ion radiation therapy, applying observations to the case for an Australian facility and to the clinical and research potential from such a national centre.

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Organs at risk dose constraints in carbon ion radiotherapy at MedAustron: Translations between LEM and MKM RBE models and preliminary clinical results

Cited by 11 publications

References 25 publications

Dose–volume constraints for head‐and‐neck cancer in carbon ion radiotherapy: A literature review

Dose–volume constraints for head‐and‐neck cancer in carbon ion radiotherapy: A literature review

Carbon Ion Radiotherapy in the Treatment of Hepatocellular Carcinoma

The rationale for a carbon ion radiation therapy facility in Australia

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