Organspende bei Patienten nach nicht traumatischem außerklinischem Herzstillstand

Christ, Martin; Auenmüller, Katharina Isabel von; Brand, Michael; Gessner, Verena; Grett, Martin; Zalloum, Nedall; Dierschke, Wolfgang; Trappe, Hans‐Joachim

doi:10.1055/s-0043-119394

Cited by 1 publication

(1 citation statement)

References 13 publications

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“…A 2016 meta-analysis showed that 13% of patients who died after OHCA developed brain death and that, among these, 42% (6% of all deceased patients) became organ donors [ 6 ]. This result was consistent with previous studies [ 7 – 10 , 15 , 28 , 30 , 31 ]. In our study, the corresponding proportions were 16% and 28%.…”

Section: Discussionsupporting

confidence: 94%

Organ donation after out-of-hospital cardiac arrest: a population-based study of data from the Paris Sudden Death Expertise Center

Renaudier

Binois²,

Charpentier³

et al. 2022

Ann. Intensive Care

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Background Organ shortage is a major public health issue, and patients who die after out-of-hospital cardiac arrest (OHCA) could be a valuable source of organs. Here, our objective was to identify factors associated with organ donation after brain death complicating OHCA, in unselected patients entered into a comprehensive real-life registry covering a well-defined geographic area. Methods We prospectively analyzed consecutive adults with OHCA who were successfully resuscitated, but died in intensive care units in the Paris region in 2011–2018. The primary outcome was organ donation after brain death. Independent risk factors were identified using logistic regression analysis. One-year graft survival was assessed using Cox and log-rank tests. Results Of the 3061 included patients, 136 (4.4%) became organ donors after brain death, i.e., 28% of the patients with brain death. An interaction between admission pH and post-resuscitation shock was identified. By multivariate analysis, in patients with post-resuscitation shock, factors associated with organ donation were neurological cause of OHCA (odds ratio [OR], 14.5 [7.6–27.4], P < 0.001), higher pH (OR/0.1 increase, 1.3 [1.1–1.6], P < 0.001); older age was negatively associated with donation (OR/10-year increase, 0.7 [0.6–0.8], P < 0.001). In patients without post-resuscitation shock, the factor associated with donation was neurological cause of OHCA (OR, 6.9 [3.0–15.9], P < 0.001); higher pH (OR/0.1 increase, 0.8 [0.7–1.0], P = 0.04) and OHCA at home (OR, 0.4 [0.2–0.7], P = 0.006) were negatively associated with organ donation. One-year graft survival did not differ according to Utstein characteristics of the donor. Conclusions 4% of patients who died in ICU after OHCA led to organ donation. Patients with OHCA constitute a valuable source of donated organs, and special attention should be paid to young patients with OHCA of neurological cause.

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Section: Discussionsupporting

confidence: 94%

Organ donation after out-of-hospital cardiac arrest: a population-based study of data from the Paris Sudden Death Expertise Center

Renaudier

Binois²,

Charpentier³

et al. 2022

Ann. Intensive Care

View full text Add to dashboard Cite

show abstract

Organspende bei Patienten nach nicht traumatischem außerklinischem Herzstillstand

Abstract: Organ donation following OHCA is seldom. We therefore would appreciate a more frequent diagnostics of brain death as currently not even all victims of OHCA with proven signs of brain damage in the computed tomography receive further diagnostics to confirm the diagnosis of brain death.

Cited by 1 publication

References 13 publications

Organ donation after out-of-hospital cardiac arrest: a population-based study of data from the Paris Sudden Death Expertise Center

Organ donation after out-of-hospital cardiac arrest: a population-based study of data from the Paris Sudden Death Expertise Center

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