Orientation Preference Maps in Microcebus murinus Reveal Size-Invariant Design Principles in Primate Visual Cortex

Ho, Chun Lum Andy; Zimmermann, Robert A.; Weidinger, Juan Daniel Flórez; Prsa, Mario; Schottdorf, Manuel; Merlin, Sam; Okamoto, Tsukasa; Ikezoe, Koji; Pifferi, Fabien; Aujard, Fabienne; Angelucci, Alessandra; Wolf, Fred; Huber, Daniel

doi:10.1016/j.cub.2020.11.027

Cited by 23 publications

(23 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was especially surprising that the mouse lemur, a tiny (~60-80 g) prosimian primate species [37], could segment purely motion-defined figures well above chance, while the treeshrew (~120-200 g), an animal with a much more highly developed visual system than the mouse [38][39][40], could not. Overall, our findings reveal a fundamental difference in the computational strategy used by mice versus primates for visual segmentation and suggest that surface perception from accretion-deletion may be a capability unique to primates.…”

Section: Discussionmentioning

confidence: 99%

Mice and primates use distinct strategies for visual segmentation

Liu

Cla

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

The rodent visual system has attracted great interest in recent years due to its experimental tractability, but the fundamental mechanisms used by the mouse to represent the visual world remain unclear. In the primate, researchers have argued from both behavioral and neural evidence that a key step in visual representation is "figure-ground segmentation," the delineation of figures as distinct from backgrounds [1-4]. To determine if mice also show behavioral and neural signatures of figure-ground segmentation, we trained mice on a figure-ground segmentation task where figures were defined by gratings and naturalistic textures moving counterphase to the background. Unlike primates, mice were severely limited in their ability to segment figure from ground using the opponent motion cue, with segmentation behavior strongly dependent on the specific carrier pattern. Remarkably, when mice were forced to localize naturalistic patterns defined by opponent motion, they adopted a strategy of brute force memorization of texture patterns. In contrast, primates, including humans, macaques, and mouse lemurs, could readily segment figures independent of carrier pattern using the opponent motion cue. Consistent with mouse behavior, neural responses to the same stimuli recorded in mouse visual areas V1, RL, and LM also did not support texture-invariant segmentation of figures using opponent motion. Modeling revealed that the texture dependence of both the mouse's behavior and neural responses could be explained by a feedforward neural network lacking explicit segmentation capabilities. These findings reveal a fundamental limitation in the ability of mice to segment visual objects compared to primates.

show abstract

Section: Discussionmentioning

confidence: 99%

Mice and primates use distinct strategies for visual segmentation

Liu

Cla

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Equation ( 3) gives the PWC density in terms of the PWC separation in the hexagonal lattice. Some previous works argued for a universal PWC density in aperiodic arrangements of PWCs, expressed in terms of the mean periodicity Λ of OP, independent of species [22,33,34], with…”

Section: Possible Od-op-dp Topologiesmentioning

confidence: 99%

“…And the pinwheel spacing a of the hexagonal lattice that is derived from these three data sets. ρ (mm −2 ) λ ⊥ (mm) Λ (mm) a from λ ⊥ (mm) a from ρ (mm) a from Λ (mm) Human [59] 2.24 1.17 ± 0.08 1.43 ± 0.12 0.78 ± 0.05 0.68 0.65 ± 0.05 Macaque [22,44,45]…”

Section: Possible Od-op-dp Topologiesmentioning

confidence: 99%

Mutual Consistency of Multiple Visual Feature Maps Constrains Combined Map Topology

Liu¹,

Robinson²

2021

Preprint

View full text Add to dashboard Cite

The topologies permitted in joint ocular dominance (OD), orientation preference (OP), and direction preference (DP) maps in the primary visual cortex (V1) are considered, with the aim of finding a maximally symmetric periodic case that can serve as the basis for perturbations toward natural realizations. It is shown that mutual consistency of the maps selects just two possible such lattice structures, and that one of these is much closer to experiment than the other. This comprises a hexagonal lattice of alternating positive and negative OP singularities, with each unit cell or hypercolumn containing four such singularities, each radiating three DP discontinuities that follow OP contours and end at OP singularities of opposite sign. Other DP discontinuities emanate at 90 degrees to the midpoints of the ones that link OP singularities, and cross OP contours perpendicularly. These features explain experimentally observed relationships between DP discontinuities and OP contours, including sudden approximately 90-degree changes of direction in the former.

show abstract

“…For example, while the selective responses of neurons in the visual cortex to the orientation of edges follows a well-defined pinwheel-like organization in cats (Bonhoeffer and Grinvald, 1991;Ohki et al, 2006), similar patterns are generally thought to be absent in rodents (Van Hooser et al, 2005), although some, much looser, functional organization has recently been described in mice (Fahey et al, 2019;Ringach et al, 2016). The exact implications of differences in functional organization in these areas are still under debate, in particular how brain size, etiological and environmental demands on specific aspects of stimulus processing might favor one architecture over another (Ho et al, 2021;Koch et al, 2016;Swindale et al, 2000).…”

Section: Introductionmentioning

confidence: 97%

Functional network topography of the medial entorhinal cortex

Obenhaus¹,

Zong²,

Jacobsen³

et al. 2021

Preprint

View full text Add to dashboard Cite

The medial entorhinal cortex (MEC) creates a map of local space, based on the firing patterns of grid, head direction (HD), border, and object-vector (OV) cells. How these cell types are organized anatomically is debated. In-depth analysis of this question requires collection of precise anatomical and activity data across large populations of neurons during unrestrained behavior, which neither electrophysiological nor previous imaging methods fully afford. Here we examined the topographic arrangement of spatially modulated neurons in MEC and adjacent parasubiculum using miniaturized, portable two-photon microscopes, which allow mice to roam freely in open fields. Grid cells exhibited low levels of co-occurrence with OV cells and clustered anatomically, while border, HD and OV cells tended to intermingle. These data suggest that grid-cell networks might be largely distinct from those of border, HD and OV cells and that grid cells exhibit strong coupling among themselves but weaker links to other cell types.

show abstract

Orientation Preference Maps in Microcebus murinus Reveal Size-Invariant Design Principles in Primate Visual Cortex

Abstract: Highlights d Mouse lemur V1 possesses orientation preference maps with pinwheel arrangement d The size and statistics of mouse lemur V1 pinwheels are comparable to the macaque d Orientation preference columns only weakly scale with body size in primates

Cited by 23 publications

References 87 publications

Mice and primates use distinct strategies for visual segmentation

Mice and primates use distinct strategies for visual segmentation

Mutual Consistency of Multiple Visual Feature Maps Constrains Combined Map Topology

Functional network topography of the medial entorhinal cortex

Contact Info

Product

Resources

About