Orientation tuning and receptive field structure in cat striate neurons during local blockade of intracortical inhibition

Eysel, Ulf; Shevelev, I. A.; Lazareva, N. A.; Sharaev, G. A.

doi:10.1016/s0306-4522(97)00378-3

Cited by 64 publications

(29 citation statements)

References 39 publications

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“…Feedforward excitation from pyramidal neurons onto interneurons is a well established fact of cortical architecture (Shepherd, 1974), although there are more physiological investigations of feedforward inhibition onto principal neurons than the reverse (Eysel, 1992;Gulyas et al, 1993;Buhl et al, 1997;Eysel et al, 1998). However, the nature of inhibitory input on neurons in the same cortical column (presumably LACs) or in neighboring cortical columns (for MACs and WACs) is highly relevant to the function of lateral inhibitory mechanisms controlling neuronal excitability generally and receptive field conformation specifically.…”

Section: Pyramidal Cell Innervation Of Lacs Macs and Wacsmentioning

confidence: 99%

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Prefrontal Microcircuits: Membrane Properties and Excitatory Input of Local, Medium, and Wide Arbor Interneurons

2001

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To elucidate cortical mechanisms involved in higher cortical functions such as working memory, we have examined feedforward excitation transmitted by identified pyramidal cells to interneurons with predominantly horizontal axonal arbors, using dual somatic recordings in prefrontal cortical slices. Interneurons with local (narrow) axonal arbors, especially chandelier interneurons, exhibited extremely narrow action potentials and high evoked firing rates, whereas neurons identified with wide arbor axons generated wider spikes and lower evoked firing rates with considerable spike adaptation, resembling that of pyramidal cells. Full reconstruction of differentially labeled neuronal pairs revealed that local arbor cells generally received a single but functionally reliable putative synaptic input from the identified pyramidal neuron member of the pair. In contrast, more synapses (two to five) were necessary to depolarize medium and wide arbor neurons reliably. The number of putative synapses and the amplitude of the postsynaptic response were remarkably highly correlated within each class of local, medium, and wide arbor interneurons (r ϭ 0.88, 0.95, and 0.99, respectively). Similarly strong correlations within these subgroups were also present between the number of putative synapses and variance in the EPSP amplitudes, supporting the validity of our morphological analysis. We conclude that interneurons varying in the span of their axonal arbors and hence in the potential regulation of different numbers of cortical modules differ also in their excitatory synaptic input and physiological properties. These findings provide insight into the circuit basis of lateral inhibition and functional interactions within and between cortical columns in the cerebral cortex.

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Section: Pyramidal Cell Innervation Of Lacs Macs and Wacsmentioning

confidence: 99%

“…In visual cortex they contribute to orientation and direction tuning of excitatory neurons (Sillito, 1975;Eysel et al, 1998). Lateral inhibition, including oblique-and cross-orientation inhibition (Kisvarday et al, 1994), has been hypothesized to account for these effects (Sillito, 1984;Eysel, 1992).…”

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confidence: 99%

Prefrontal Microcircuits: Membrane Properties and Excitatory Input of Local, Medium, and Wide Arbor Interneurons

2001

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“…In sensory systems, inhibitory neurotransmission works along with excitation to shape multiple aspects of neuronal responses, including tuning, activation thresholds, and temporal response properties (Sillito, 1977(Sillito, , 1979Sanes and Rubel, 1988;Eysel et al, 1998;Tremere et al, 2001a;Tremere and Pinaud, 2005). Inhibition also contributes significantly to experience-and injury-induced plasticity in central sensory neurons of multiple modalities (Jacobs and Donoghue, 1991;Zheng and Knudsen, 1999;Tremere et al, 2001b;Tremere and Pinaud, 2005;Teo et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Expression and rapid experience‐dependent regulation of type‐A GABAergic receptors in the songbird auditory forebrain

Jeong

Terleph

Burrows

et al. 2011

Developmental Neurobiology

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GABAergic transmission influences sensory processing and experience-dependent plasticity in the adult brain. Little is known about the functional organization of inhibitory circuits in the auditory forebrain of songbirds, a robust model extensively used in the study of central auditory processing of behaviorally relevant communication signals. In particular, no information is currently available on the expression and organization of GABAA receptor-expressing neurons. Here, we studied the distribution and regulation of GABAA receptors in the songbird auditory forebrain, with a specific focus on α5, a subunit implicated in tonic inhibition and sensory learning. We obtained a zebra finch cDNA that encodes the α5-subunit (GABRA5) and carried out a detailed analysis of its expression via in situ hybridization. GABRA5 was highly expressed in the caudomedial nidopallium (NCM), caudomedial mesopallium, and field L2. Using double fluorescence in situ hybridization, we demonstrate that a large fraction of GABRA5-expressing neurons is engaged by auditory experience, as revealed by the song-induced expression of the activity-dependent gene zenk. Remarkably, we also found that α5 expression is rapidly regulated by sensory stimulation: 30 min of conspecific song playbacks significantly increase the number of GABRA5-expressing neurons in NCM, but not in other auditory areas. This effect is selective for α5, but not γ2 transcripts. Our results suggest that α5-containing GABAA receptors likely play a key role in central auditory processing and may contribute to the experience-dependent plasticity underlying auditory learning.

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“…There are essentially two models explaining the mechanisms of orientation selectivity, the feedforward model that relies on the input from the LGN [1,[4][5][6][7][8] and the feedback model that relies on global inhibition to refi ne the selectivity to a weak bias provided by LGN input [3,[9][10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Orientation selectivity in cat primary visual cortex: local and global measurement

Yan

Song

et al. 2015

Neurosci. Bull.

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In this study, we investigated orientation selectivity in cat primary visual cortex (V1) and its relationship with various parameters. We found a strong correlation between circular variance (CV) and orthogonal-topreferred response ratio (O/P ratio), and a moderate correlation between tuning width and O/P ratio. Moreover, the suppression far from the peak that accounted for the lower CV in cat V1 cells also contributed to the narrowing of the tuning width of cells. We also studied the dependence of orientation selectivity on the modulation ratio for each cell, which is consistent with robust entrainment of the neuronal response to the phase of the drifting grating stimulus. In conclusion, the CV (global measure) and tuning width (local measure) are signifi cantly correlated with the modulation ratio.

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Orientation tuning and receptive field structure in cat striate neurons during local blockade of intracortical inhibition

Cited by 64 publications

References 39 publications

Prefrontal Microcircuits: Membrane Properties and Excitatory Input of Local, Medium, and Wide Arbor Interneurons

Prefrontal Microcircuits: Membrane Properties and Excitatory Input of Local, Medium, and Wide Arbor Interneurons

Expression and rapid experience‐dependent regulation of type‐A GABAergic receptors in the songbird auditory forebrain

Orientation selectivity in cat primary visual cortex: local and global measurement

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