Orientierende Untersuchungen zum Stoffwechsel verschiedenartiger akalorischer Verbindungen mit fettähnlichen Eigenschaften bei der Ratte

Abstract

Pseudofats as total substituted long-chain esters and ethers of polyhydroxyl compounds (sucrose, triglycerol, and polyethyleneglycol) are more or less indifferent against gastrointestinal enzymes, but display specific metabolic effects on lipid metabolism especially on cholesterol synthesis in liver, plasma lipid level, and fecal cholesterol excretion. Among the different tested compounds there exist similarities as well as differences, which are to consider as an indication for a specific relationship between structure and effect. These relations are more closely investigated and critically discussed.

Oxidation and accumulation of sucrose polyesters after i.v. application in rats (Short communication)

“…Their application leads to an increase of fecal cholesterol excretion. which is accompanied by a significant stimulation of the cholesterol synthesis in the liver and partly by a reduction of the lipid level in serum [3,4). SPE are consequently potential substitutes for dietary 1ats in foodstoffs to reduce energy intake and the serum lipid level [5.…”