Orientin, a C-glycosyl dietary flavone, suppresses colonic cell proliferation and mitigates NF-κB mediated inflammatory response in 1,2-dimethylhydrazine induced colorectal carcinogenesis

Thangaraj, Kalaiyarasu; Vaiyapuri, Manju

doi:10.1016/j.biopha.2017.11.088

Cited by 38 publications

(29 citation statements)

References 43 publications

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“…The lipid peroxidation and antioxidant status proposed to be useful indicators for determining the risk of oxidative damage induced carcinogenesis [ 20 , 10 ]. In our study, the prominent increase of circulatory TBARS could be due to too much ROS generation and disintegration of cell membranes advancing to epithelial cell transformation [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

“…Orientin (Luteolin -8-glucoside) belonging to the subclass of flavones namely C-glycosyl flavonoid was copiously found in rooibos tea, passion fruit and isolated from various medicinal plants such as tulsi and bamboo Leaves [ [20] , [21] , [22] ]. It is a water-soluble flavonoid with a molecular formula of C 21 H 20 O 11 and a molecular weight of 448.3769 g/mol; contains mostly phenol groups with two ether groups and a ketone group as shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

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Orientin, a flavanoid, mitigates 1, 2 dimethylhydrazine-induced colorectal lesions in Wistar rats fed a high-fat diet

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Orientin, a flavanoid, mitigates 1, 2 dimethylhydrazine-induced colorectal lesions in Wistar rats fed a high-fat diet

et al. 2018

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“…Antiproliferative effects [396]. Improved tumor marker levels and decreased proliferative marker levels [396].…”

Section: Orientinmentioning

confidence: 99%

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Tomko

Whynot

Ellis

et al. 2020

Cancers

162

139

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In recent years, and even more since its legalization in several jurisdictions, cannabis and the endocannabinoid system have received an increasing amount of interest related to their potential exploitation in clinical settings. Cannabinoids have been suggested and shown to be effective in the treatment of various conditions. In cancer, the endocannabinoid system is altered in numerous types of tumours and can relate to cancer prognosis and disease outcome. Additionally, cannabinoids display anticancer effects in several models by suppressing the proliferation, migration and/or invasion of cancer cells, as well as tumour angiogenesis. However, the therapeutic use of cannabinoids is currently limited to the treatment of symptoms and pain associated with chemotherapy, while their potential use as cytotoxic drugs in chemotherapy still requires validation in patients. Along with cannabinoids, cannabis contains several other compounds that have also been shown to exert anti-tumorigenic actions. The potential anti-cancer effects of cannabinoids, terpenes and flavonoids, present in cannabis, are explored in this literature review.

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“…Extracts are considered fermented unless otherwise indicated. NFK-β, TNF-α, IL-6, iNOS and COX2, reflecting its anti-inflammatory potential [92]. Aspalathin and nothofagin inhibited LPS-mediated expression of the lipopolysaccharide (LPS) receptor (TLR4) and LPS-mediated barrier disruption.…”

Section: [101]mentioning

confidence: 99%

“…[91]. The anti-inflammatory effects of rooibos and honeybush may involve a reduction in inflammatory cytokines such as IL-6, TNF-α, COX2 [91,92,94]. It may also involve a reduction in neutrophil adhesion, and other mechanisms [96], Table 1.…”

Section: [101]mentioning

confidence: 99%

Rooibos (Aspalathus linearis) and Honeybush (Cyclopiaspp.): From Bush Teas to Potential Therapy for Cardiovascular Disease

Windvogel¹

2020

Nutraceuticals - Past, Present and Future

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Cardiovascular disease (CVD) is a leading cause of worldwide deaths. A number of risk factors for cardiovascular disease as well as type 2 diabetes and stroke present as the metabolic syndrome. Metabolic risk factors include hypertension, abdominal obesity, dyslipidaemia and increased blood glucose levels and may also include risk factors such as vascular dysfunction, insulin resistance, low high density lipoprotein (HDL) cholesterol levels and inflammation. Rooibos (Aspalathus linearis) and honeybush (Cyclopia spp.) are indigenous South African plants whose reported health benefits include anti-tumour, anti-inflammatory, anti-obesity, antioxidant, cardioprotective and anti-diabetic properties. The last two decades have seen worldwide interest and success for these plants, not only as health beverages but also as preservatives, flavourants and skincare products. This review will focus on the current literature supporting the function of these plants as nutraceuticals capable of potentially reducing the risk of cardiovascular disease.

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Orientin, a C-glycosyl dietary flavone, suppresses colonic cell proliferation and mitigates NF-κB mediated inflammatory response in 1,2-dimethylhydrazine induced colorectal carcinogenesis

Cited by 38 publications

References 43 publications

Orientin, a flavanoid, mitigates 1, 2 dimethylhydrazine-induced colorectal lesions in Wistar rats fed a high-fat diet

Orientin, a flavanoid, mitigates 1, 2 dimethylhydrazine-induced colorectal lesions in Wistar rats fed a high-fat diet

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Rooibos (Aspalathus linearis) and Honeybush (Cyclopiaspp.): From Bush Teas to Potential Therapy for Cardiovascular Disease

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