Origin and differentiation of dendritic cells

Ardavı́n, Carlos; Hoyo, Gloria Martı́nez del; Martı́n, Pilar; Anjuère, Fabienne; Arias, Cristina Fernández; Marı́n, Alvaro Rodrı́guez; Ruiz, Sara; Parrillas, Verónica; Hernández, Héctor Hernández y

doi:10.1016/s1471-4906(01)02059-2

Cited by 249 publications

(145 citation statements)

References 64 publications

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“…Each of the subsets represents a small fraction (∼0.3%) of the entire circulating blood leukocyte population [24]. More recent work has characterized these two subsets as belonging to the myeloid or lymphoid lineage and, although different denominations have been used, they can be defined as myeloid DC (M-DC) and plasmacytoid DC (P-DC) [25,26,27,28]. M-DC and P-DC differ in morphology, expression of markers and function.…”

Section: Subsetsmentioning

confidence: 99%

Ins and Outs of Dendritic Cells

Schuurhuis

Fu²,

Ossendorp³

et al. 2006

Int Arch Allergy Immunol

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Dendritic cells (DC) are professional antigen-presenting cells which are strategically positioned at the boundaries between the inner and the outside world, in this way bridging innate and adaptive immunity. DC can initiate T cell responses against microbial pathogens and tumors due to their capacity to stimulate naïve T cells. The development of DC occurs in distinct stages. DC precursors develop in the bone marrow and home to a large variety of tissues. Immature DC capture antigen (Ag) and, following proinflammatory signals, migrate to the lymphoid organs where, after maturation, they present captured Ag to naïve T cells, thereby inducing differentiation of naïve T cells into effector T cells. An important cognate event in the development of cell-mediated immunity is the interaction between CD40 and CD40 ligand. Ligation of CD40 on DC by its ligand results in maturation of the DC. In addition to CD40 ligand (expressed by activated Th cells), inflammatory cytokines, bacterial components or Ag-Ab immune complexes can induce maturation of DC. Maturation of DC is crucial for the priming of efficient T cell responses and is characterized by a decreased Ag processing capacity, an increased cell surface expression of MHC and costimulatory molecules, and rearrangement of cytoskeleton, adhesion molecules, and cytokine receptors. Mature DC migrate from peripheral tissues to secondary lymphoid organs, where T cell priming occurs. DC are not only critical in initiating T cell immunity, they also play a role in the induction of T cell tolerance and the regulation of the type of T cell response that is induced. Here we give an overview of the dendritic cell system.

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Section: Subsetsmentioning

confidence: 99%

Ins and Outs of Dendritic Cells

Schuurhuis

Fu²,

Ossendorp³

et al. 2006

Int Arch Allergy Immunol

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“…They have a dendritic shape and are found mainly at the corticomedullary border and in the medullary region of the thymus (Lafontaine et al 1997). The function of TDC is generating central T-cell tolerance through the deletion or negative selection of autoreactive thymocytes (Gaillard et al 1993;Vicente et al 1994;Shortman and Caux 1997;Ardavin 1997;Ardavin et al 2001;Vandenabeele et al 2001;Varas et al 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Ardavin et al (2001) have been proposed that TDC should develop intrathymically. Indeed, endogenous DC precursors have been found in the normal thymus (Varas et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Development and maturation of thymic dendritic cells during human ontogeny

2006

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Thymic dendritic cells (TDC) are dendritic cells situated mainly in the cortico-medullary zone and in the medullary region of the thymus. However, the phenotype of TDC during ontogeny is poorly documented. The aim of this study has been to investigate the development and maturation of TDC during human ontogeny. Immunohistochemical analyses and immunoelectron-microscopic investigation of 21 human thymus specimens have been performed to detect the subtypes of TDC by using various DC-related and DC-development-related markers. TDC express a Langerhans-cell-like phenotype during human ontogeny. Cells expressing thymic stromal lymphopoietin receptor have been observed in Hassal's corpuscles of the thymus. Granulocyte/macrophage colony-stimulating factor (GM-CSF) is also expressed in thymic epithelial cells (TEC) localized in Hassal's corpuscles. During human ontogeny, GM-CSF is produced by TEC of Hassal's corpuscles and might play a key role in the differentiation of TDC having Langerhans-cell-like phenotypes.

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“…They are heterogeneous with regard to their origin and maturation states and are variously termed according to the organ, surface markers and morphology. Consensus states that DCs originate from a hematopoietic progenitor and have myeloid and lymphoid pathways of differentiation [3]. DCs distributed throughout the body (except for the brain) are also called Langerhans cells, dermal dendritic cells, interstitial dendritic cells and veiled cells.…”

Section: Introductionmentioning

confidence: 99%

Fascin-positive dendritic cells and fibroblastic reticulum cells build a framework of T-cell areas in lymph nodes

et al. 2004

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Fascin, a 55-kDa actin-bundling protein, and alpha-smooth muscle actin (ASMA) were immunohistochemically examined in murine normal and stimulated lymph nodes. In specific pathogen-free young female mice, a few fascin-positive cells (FPCs) were located in the sinus and surrounding tissues, but ASMA-positive cells were undetectable. Following a subcutaneous injection of sheep red blood cells, the numbers of FPCs and their dendrites increased in the paracortex, with the accumulation of activated lymphocytes. Fibroblastic reticulum cells (FRCs), endothelial cells, histiocytic cells and lymphocytes in various stages of maturation were all fascin negative. These results indicated that fascin could be a reliable marker of paracortical dendritic cells in murine lymph nodes. However, FRCs became ASMA positive. Immunoelectron microscopy showed that the FPCs were interdigitating cells and that they closely contacted with FRCs. These two types of cells and reticular fiber formed a network in the paracortex and contacted with each other. In active paracortical response, both FPCs and FRCs are also stimulated and might play a significant role in the maturation of the lymphocytes.

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Origin and differentiation of dendritic cells

Cited by 249 publications

References 64 publications

Ins and Outs of Dendritic Cells

Ins and Outs of Dendritic Cells

Development and maturation of thymic dendritic cells during human ontogeny

Fascin-positive dendritic cells and fibroblastic reticulum cells build a framework of T-cell areas in lymph nodes

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