Origin and evolution of metabolism

Oparin, A.I.

doi:10.1016/0010-406x(62)90018-x

Cited by 11 publications

(8 citation statements)

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“…The emergence of catalysis is a premise of the metabolism-first model [47]. Once peptides evolved to recognize molecules, some could possess weak catalytic activities that break or form covalent bonds, thus becoming primitive catalysis (Figure 1, part III).…”

Section: Resultsmentioning

confidence: 99%

“…Inger et al previously suggested the GARD model for inheritance of chemical information in support of Oparin’s metabolism first hypothesis [47,67,74]. However, one limitation noted was that such a system is incapable of evolution [75].…”

Section: The Genesis Of Heredity Through Degenerate Semiconservative mentioning

confidence: 99%

“…I do not propose any change to the potential role of protocells in the origins of life; rather, I point out how the minimotif synthesis hypothesis is consistent with protocell formation. Protocells form when self-organized lipid- or fatty-acid membranes encapsulate bio-oligomers and small molecules which, in the metabolism first model, are thought to be the predecessors to cells [47,74,78,79]. Protocells containing sets of peptides, minimotifosomes, and chemicals may have been the first prebiotic entities capable of metabolism, growth, and reproduction.…”

Section: Protocellsmentioning

confidence: 99%

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The minimotif synthesis hypothesis for the origin of life

Schiller¹

2016

J Transl Sci

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Several theories for the origin of life have gained widespread acceptance, led by primordial soup, chemical evolution, metabolism first, and the RNA world. However, while new and existing theories often address a key step, there is less focus on a comprehensive abiogenic continuum leading to the last universal common ancestor. Herein, I present the “minimotif synthesis” hypothesis unifying select origin of life theories with new and revised steps. The hypothesis is based on first principles, on the concept of selection over long time scales, and on a stepwise progression toward complexity. The major steps are the thermodynamically-driven origination of extant molecular specificity emerging from primordial soup leading to the rise of peptide catalysts, and a cyclic feed-forward catalytic diversification of compound and peptides in the primordial soup. This is followed by degenerate, semi-partially conservative peptide replication to pass on catalytic knowledge to progeny protocells. At some point during this progression, the emergence of RNA and selection could drive the separation of catalytic and genetic functions, allowing peptides and proteins to permeate the catalytic space, and RNA to encode higher fidelity information transfer. Translation may have emerged from RNA template driven organization and successive ligation of activated amino acids as a predecessor to translation.

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Section: Resultsmentioning

confidence: 99%

Section: The Genesis Of Heredity Through Degenerate Semiconservative mentioning

confidence: 99%

Section: Protocellsmentioning

confidence: 99%

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The minimotif synthesis hypothesis for the origin of life

Schiller¹

2016

J Transl Sci

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“…[ 7 ]). A minimally living entity needs not be a cell as we know it but could be a much simpler protocell [ 2 , 8 – 15 ], i.e. container with some necessary molecular content.…”

Section: Introductionmentioning

confidence: 99%

“…The replicator-first approach focuses on a single self-perpetuating informational biopolymer, e.g., RNA, as the first step, and it is thus often referred to as the “RNA world” [ 16 – 20 ]. In contrast, the metabolism-first approach [ 2 , 9 , 11 , 21 – 23 ] focuses on a network of chemical reactions among simpler chemical components that became endowed with some reproductive characteristics [ 2 , 8 , 9 , 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Predicting species emergence in simulated complex pre-biotic networks

Markovitch

Krasnogor

2018

PLoS ONE

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An intriguing question in evolution is what would happen if one could “replay” life’s tape. Here, we explore the following hypothesis: when replaying the tape, the details (“decorations”) of the outcomes would vary but certain “invariants” might emerge across different life-tapes sharing similar initial conditions. We use large-scale simulations of an in silico model of pre-biotic evolution called GARD (Graded Autocatalysis Replication Domain) to test this hypothesis. GARD models the temporal evolution of molecular assemblies, governed by a rates matrix (i.e. network) that biases different molecules’ likelihood of joining or leaving a dynamically growing and splitting assembly. Previous studies have shown the emergence of so called compotypes, i.e., species capable of replication and selection response. Here, we apply networks’ science to ascertain the degree to which invariants emerge across different life-tapes under GARD dynamics and whether one can predict these invariant from the chemistry specification alone (i.e. GARD’s rates network representing initial conditions). We analysed the (complex) rates’ network communities and asked whether communities are related (and how) to the emerging species under GARD’s dynamic, and found that the communities correspond to the species emerging from the simulations. Importantly, we show how to use the set of communities detected to predict species emergence without performing any simulations. The analysis developed here may impact complex systems simulations in general.

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HILIC‐MS/MS method development for targeted quantitation of metabolites: Practical considerations from a clinical diagnostic perspective

Rappold¹,

Grant²

2011

J of Separation Science

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The development of targeted assays for polar molecules is a persistent challenge in quantitative metabolite measurement. In addressing these challenges, hydrophilic interaction liquid chromatography (HILIC) has proved to be a valuable, though under-used and poorly understood chromatographic technique. This work has addressed a number of components that are intrinsic in development of a high-throughput, specific and sensitive assay for metabolites using HILIC-MS/MS. Generally accepted HILIC doctrine, such as addition of water to all mobile phases and re-equilibration time, was shown to be flawed under gradient HILIC mode. The effect of non-classical mobile phase additives on HILIC-MS/MS specificity, sensitivity and assay throughput was shown for endogenous metabolites. A broad evaluation of columns and mobile phases for the retention of varied molecular classes was performed, elucidating the empirical nature of HILIC method development. Application of the empirical evaluations performed in the paper was demonstrated by detailing a method development cycle for methylmalonic acid to achieve a highly selective and sensitive HILIC-MS/MS quantitation capable of high-throughput analysis for clinical utility.

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Origin and evolution of metabolism

Cited by 11 publications

References 0 publications

The minimotif synthesis hypothesis for the origin of life

The minimotif synthesis hypothesis for the origin of life

Predicting species emergence in simulated complex pre-biotic networks

HILIC‐MS/MS method development for targeted quantitation of metabolites: Practical considerations from a clinical diagnostic perspective

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