“…Myofibroblasts are the primary source of extracellular matrix (ECM), which is deposited in the renal interstitium during fibrogenesis. The anatomic origin of interstitial myofibroblasts responsible for excessive matrix production is still an area of controversy, and various origins have been proposed including adult kidney nephrogenic progenitors, stroma, bone marrow-derived cells, damaged epithelium, and endothelium (3,(7)(8)(9)(10)(11)(12)(13)(14)(15). Most likely, interstitial myofibroblasts in renal fibrosis originate from multiple sources but to various extents; the majority, however, appears to originate from the FOXD1 lineage, which gives rise to pericytes, Abbreviations: ATA, acetylthioacetate; DMF, dimethylformamide; ECM, extracellular matrix; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; GMBS, g-maleimidobutyryloxy-succinimide ester; HRP, horseradish peroxidase; HSA, human serum albumin; IF, interstitial fibrosis; IFN-gR1, IFN-g receptor 1; JAK/STAT, Janus kinase/signal transducers and activators of transcription signaling pathway; LTA, lotus tetragonolobus; LTL, lotus tetragonolobus lectin;…”