Origin of anti-tumor immunity failure in mammals and new possibility for immunotherapy

Bubanovic, Ivan

doi:10.1016/s0306-9877(02)00263-3

Cited by 8 publications

(11 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elevated levels of cytokines such as IL-4, IL-6, IL-10 and TGF-β (Th2 and Th3 cytokines) are labels of both progressive malignant disease and successful pregnancy. Similarly, decreased levels of IL-2, IL-12, IL-18, IFN-γ and TNF-α (Th1 cytokines) are specific for progressive malignant disease and successful pregnancy (reviewed in Bubanovic, 2003a;Raghupathy et al, 2000;Wegmann et al, 1993).…”

Section: Basic Mechanisms For the Escape Of Tumors And Trophoblast Frmentioning

confidence: 99%

“…11) The mammalian immune system may be tolerant to cancer cells because they are very similar to trophoblast cells (reviewed in Bubanovic, 2003a). 12) Sex hormones, steroids and other factors, which are attributes of pregnancy and malignant processes, can impair the blood-thymus barrier.…”

Section: Tumors In Mammals and Other Classes Of Vertebratesmentioning

confidence: 99%

“…Finally, trophoblast or embryonic cells or their antigens can be used for anti-tumor immunization. Taking into consideration the fact that anti-tumor immunity failure in mammals is an immunoreproductive phenomenon could open many new possibilities for immunotherapy of malignant diseases (reviewed in Bubanovic, 2003a).…”

Section: Tumors In Mammals and Other Classes Of Vertebratesmentioning

confidence: 99%

“…Also, the immunological properties of the two tissues are very similar. Whether or not cancer originated from a trophoblast, the cells and the immunological events appear to act in a similar way (reviewed in Bubanovic, 2003aBubanovic, , 2003d.…”

Section: Introductionmentioning

confidence: 99%

“…The fact that mammals are the only vertebrates that have a placenta gives us an opportunity to compare anti-tumor immunity in mammals and other classes of vertebrates. Detection of the anti-tumor mechanisms in non-mammalian classes of vertebrates can be very usable in efforts to prove the connection between pregnancy and malignancy (reviewed in Bubanovic, 2003a). …”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Ideas in Theoretical Biology - Failure of Anti-Tumor Immunity in Mammals - Evolution of the Hypothesis

Bubanovic

Najman²

2004

Acta Biotheor

View full text Add to dashboard Cite

Observations on the morphological and functional similarity between embryonic or trophoblast tissues and tumors are very old. Over a period of time many investigators have created different hypotheses on the origin of cancerogenesis or tumor efficiency in relation to the host immune system. Some of these ideas have been rejected but many of them are still current. A presumption of the inefficiency of anti-tumor immunity in mammals due to the high similarity between trophoblast and embryonic cells to tumor cells is very real. The mechanisms for the escape of tumors from the immune response are very similar to the mechanisms for the escape of a fetoplacental unit from the maternal immune response. The similarity between these two mechanisms is so great that any randomness must be banished. At the same time, an incidence of malignant tumors and the types of more frequent tumors in non-mammalian vertebrates is significantly different to that in mammals. Lastly, the mechanisms of anti-tumor immunity in mammals are substantially different from the mechanisms of anti-tumor immunity in other classes of vertebrates. These facts indicate that the immune system of mammals during anti-tumor immune response is tricked by the similarity between tumor cells and trophoblast or other placental cells. From this aspect, our conclusion is that anti-tumor immunity failure in mammals can be defined as an immunoreproductive phenomenon, which is developed under the evolutionary pressure of autoimmunity and reproductive effectiveness.

show abstract

Section: Basic Mechanisms For the Escape Of Tumors And Trophoblast Frmentioning

confidence: 99%

Section: Tumors In Mammals and Other Classes Of Vertebratesmentioning

confidence: 99%

Section: Tumors In Mammals and Other Classes Of Vertebratesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations