Origin of Arterial Prosthesis Lining From Circulating Blood Cells

Mackenzie, James; Hackett, M.E.J.; Topuzlu, Cemalettin; Tibbs, David J.

doi:10.1001/archsurg.1968.01340060057005

Cited by 44 publications

(14 citation statements)

References 4 publications

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“…One year later "the development of organized vessels in cultures of blood cells" and in 1950 "in vitro blood vessel" formation from bone marrow of adult chickens were described (Parker, 1933;White and Parshley, 1950). In addition, reports of fallout endothelialization, i.e., endothelialization of grafts by blood-derived cells, have been appearing almost as long as synthetic arterial grafts have been in use (Stump et al, 1963;Mackenzie et al, 1968;Scott et al, 1994;Shi et al, 1994). Elegant studies by Sauvage and colleagues showed that when blood flow is present, implanted synthetic arterial grafts can be reendothelialized even when endothelial cell ingrowth from the anastomoses and the vaso vasorum are apparently prevented (Shi et al, 1994;Wu et al, 1995).…”

Section: Adult Hemangioblasts and Vasculogenesismentioning

confidence: 99%

Hemangioblasts, angioblasts, and adult endothelial cell progenitors

Schatteman

Awad

2003

Anat. Rec.

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After decades of speculation, proof of embryonic hemangioblasts finally emerged a few years ago. Surprisingly, at about the same time, evidence for adult hemangioblasts began to appear, and recent single-cell bone marrow transplants have confirmed their existence. Embryonic and adult hemangioblasts appear to share antigenic determinants, including CD34, ACC133, and VEGFR2, although their phenotype may be plastic. They also respond to similar factors, prominent among them vascular endothelial growth factor (VEGF). In the adult, hemangioblasts reside principally in the bone marrow, although they may subsequently leave that niche to reside in nonhematopoietic tissues. A number of studies indicate that these cells or their progeny may be a significant source of endothelial cells in adult pathologic and nonpathologic vascularization, and may participate in vascular repair. In addition to hemangioblasts, a more differentiated source of endothelial cell progenitors may be present in the blood, namely, monocytes or monocytic-like cells. The relative importance of the two cell types in vivo is not clear, though endothelial cells derived from the two sources may not be identical, and hemangioblasts seem to provide a stimulus for differentiation of the monocytes. Treatment with exogenous bone marrow-derived cells can promote neovascularization, accelerate restoration of blood flow to ischemic tissues, and improve cardiac function after infarct. Hence, there is great hope that either alone, in combination with angiogenic factors, or as gene therapy vectors, we can harness these cells to treat ischemic and vascular diseases in the relatively near future. Anat Rec Part A 276A: 13-21, 2004.

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Section: Adult Hemangioblasts and Vasculogenesismentioning

confidence: 99%

Hemangioblasts, angioblasts, and adult endothelial cell progenitors

Schatteman

Awad

2003

Anat. Rec.

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“…In the same way we have been looking for the degree of endothelialization of the neointima because of its dependence of the underlying layer and its viability {Stump Mackenzie et al, 1968). As mentioned before, the migration of connective tissue through the pores are fixing the neointima to the prostheses and thereby preventing dislodgement.…”

Section: Discussionmentioning

confidence: 99%

“…In the evaluation of the viability of the neointima, the vascular growth through the grafts has been studied because of its obvious importance (Macpherson and Muir, 1963;Warren, 1965;Mackenzie et al, 1968). In the same way we have been looking for the degree of endothelialization of the neointima because of its dependence of the underlying layer and its viability {Stump Mackenzie et al, 1968).…”

Section: Discussionmentioning

confidence: 99%

Influence of Porosity on the Viability of the Neointima

Hermansen¹,

Kraglund²,

Ludwigsen³

et al. 1980

Eur Surg Res

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The influence of porosity on the viability of the neointima was evaluated in two types of Dacron vascular prostheses with quite different porosities. It could be concluded that the observed parietal thrombus formation in functioning prostheses, and the dislodgement of the neointima in several of these, might well be attributed to the low porosity of the investigated prostheses, as compared to the recommended value. At the same time it is remarkable that no pronounced difference in the histological picture was observed in the two types of prostheses, despite large differences in their mutual porosities.

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“…· (17) considered that round cells in the blood may be undifferentiated multipotential cells that may differentiate into various mature cells. We believe that epithelium migration from the arterial edge is the main source for re-endothelialization of the inner surface because the sections' examinations confirmed that a layer of intact endothelial cells covering the inner surface of the graft linked up with the epithelium of the adjacent arteries in our experiment.…”

Section: Control Groupmentioning

confidence: 99%