Origin of Canine Distemper Virus: Consolidating Evidence to Understand Potential Zoonoses

Quintero-Gil, Carolina; Rendón-Marín, Santiago; Martínez-Gutiérrez, Marlen; Ruíz-Saenz, Julián

doi:10.3389/fmicb.2019.01982

Cited by 16 publications

(24 citation statements)

References 41 publications

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“…CDV is a pathogen that affects a vast array of animal species, including domestic dogs, wild animals and non-human primates [ 2 ]. However, to date, the potential cross-species transmission to humans has not been fully understood [ 36 , 37 , 38 ]. Considering CDV as potential zoonotic virus has important implications in public health, due to the proximity among potential transmitters such as domestic dogs and humans.…”

Section: Discussionmentioning

confidence: 99%

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RETRACTED: Canine Morbillivirus from Colombian Lineage Exhibits In Silico and In Vitro Potential to Infect Human Cells

et al. 2021

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Canine morbillivirus (CDV) is a viral agent that infects domestic dogs and a vast array of wildlife species. It belongs to the Paramyxoviridae family, genus Morbillivirus, which is shared with the Measles virus (MeV). Both viruses employ orthologous cellular receptors, SLAM in mononuclear cells and Nectin-4 in epithelial cells, to enter the cells. Although CDV and MeV hemagglutinin (H) have similar functions in viral pathogenesis and cell tropism, the potential interaction of CDV-H protein with human cellular receptors is still uncertain. Considering that CDV is classified as a multi-host pathogen, the potential risk of CDV transmission to humans has not been fully discarded. In this study, we aimed to evaluate both in silico and in vitro, whether there is a cross-species transmission potential from CDV to humans. To accomplish this, the CDV-H protein belonging to the Colombian lineage was modelled. After model validations, molecular docking and molecular dynamics simulations were carried out between Colombian CDV-H protein and canine and human cellular receptors to determine different aspects of the protein–protein interactions. Moreover, cell lines expressing orthologous cellular receptors, with both reference and wild-type CDV strains, were conducted to determine the CDV cross-species transmission potential from an in vitro model. This in silico and in vitro approach suggests the possibility that CDV interacts with ortholog human SLAM (hSLAM) and human Nectin-4 receptors to infect human cell lines, which could imply a potential cross-species transmission of CDV from dogs to humans.

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Section: Discussionmentioning

confidence: 99%

“…The cross-species transmission potential of CDV to humans has been proposed prior to this study [ 36 , 37 , 42 , 43 ]. The CDV Ac96I strain was reported to infect human epithelial cell lines expressing the Nectin-4 cellular receptor, but not hSLAM [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Canine Morbillivirus from Colombian Lineage Exhibits In Silico and In Vitro Potential to Infect Human Cells

et al. 2021

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“…Teniendo en cuenta que el CDV puede afectar a una amplia gama de especies, incluidos los animales domésticos y silvestres, se ha propuesto la posible transmisión entre especies a los humanos, debido a la aparición de diversos linajes diferentes (45). Aunque, hasta la fecha, no hay evidencia de infección humana por CDV, el virus ha sido aislado in vivo de primates no humanos e in vitro en líneas celulares humanas, destacando la posibilidad de un salto zoonótico a los humanos en ausencia de inmunidad viral por sarampión (46,47). Importantes medidas y controles fronterizos deben tomarse para las mascotas que viajan entre países, a fin de evitar la propagación del virus de una región a otra.…”

Section: Virus Reemergentes De Importancia Para Animales De Compañíaunclassified

A concise review on certain important veterinary viruses in the Americas

Giraldo-Ramirez¹,

Rendón-Marín²,

Ruíz-Saenz³

2021

Rev MVZ Córdoba

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Animals have become an essential member for our society, with roles related to company, human well-being and therapy for some diseases, and as a source of food in many populations around the world. Animals intended for human consumption like pigs and cattle, as well as companion animals, specifically cats and dogs, are constantly threatened by multiple viral agents. This puts at risk pet owners and threatens food security in the region. Considering that control or eradication is a complex problem that involves several aspects, there is a limited success in this regard for viral diseases such as foot-and-mouth disease, rabies and classical or African swine fever, this review aims to show the most important characteristics, in the epidemiological context, from farm animals virus, re-emerging viruses affecting companion animals, and emerging and re-emerging zoonotic viruses. Since viral pathogens affect animal populations and human well-being, there is a need to increase efforts to control, monitor and eradicate them from livestock and companion animals. The following sections contribute to improve the understanding of these viral agents and orchestrate actions of control entities in the Americas.

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“…Canine distemper is a disease of dogs and wild carnivores caused by the canine morbillivirus (previously called distemper virus, CDV), belonging to the genus Morbillivirus, family Paramyxoviridae [1]. Closely related paramyxoviruses, such as the phocine morbillivirus (phocid distemper virus), rinderpest virus in animals and measles virus in humans are important pathogens [2]. Canine distemper virus is spread worldwide and is associated with highly contagious infection in susceptible species.…”

Section: Introductionmentioning

confidence: 99%

Canine Distemper Virus in Wild Carnivore Populations from the Czech Republic (2012–2020): Occurrence, Geographical Distribution, and Phylogenetic Analysis

Kličková

Černíková

Dumondin³

et al. 2022

Life

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Canine distemper is a highly contagious viral disease in carnivores and represents a serious threat for both wild and domestic animals. The aim of our study was to monitor the occurrence of the canine distemper virus in wildlife from the Czech Republic, reveal the H gene heterogeneity in positive samples and perform subsequent phylogenetic analysis. In total, 412 wild animals of 10 species were included in the study: 219 red foxes (Vulpes vulpes), 79 European badgers (Meles meles), 47 European otters (Lutra lutra), 40 stone martens (Martes foina), 10 pine martens (M. martes), 7 raccoons (Procyon lotor), 5 undetermined martens (Martes sp.), 2 wolves (Canis lupus), 1 European polecat (Mustela putorius), 1 free-ranging ferret (Mustela putorius furo), and 1 free-ranging American mink (Neovison vison). Most animals were found dead or were killed by hunters during hunting seasons in the years 2012–2020 and came from all 14 regions of the Czech Republic. In the animals that were hunted, symptoms such as apathy, loss of shyness or disorientation were reported. Canine distemper virus (CDV) was detected by real-time RT-PCR in the tissues of 74 (18%) of the animals, including 62 (28%) red foxes, 4 (10%) stone martens, 3 (43%) raccoons, 2 (20%) pine martens, 2 (2.5%) European badgers and 1 (20%) undetermined marten. There was a statistical difference in positivity among animal species (p < 0.0001), regions (p = 0.0057), and the years of sampling (p = 0.0005). To determine the genetic characteristics of circulating variants of CDV in wildlife, 23 of 74 CDV variants were partially sequenced. Phylogenetic analysis showed that 21 variants belonged to the European lineage and two strains belonged to the European-Wildlife lineage. This study provides the first comprehensive overview of the prevalence and spatial distribution of CDV in wildlife in the Czech Republic, including molecular phylogenetic analysis of currently circulating CDV lineages.

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Origin of Canine Distemper Virus: Consolidating Evidence to Understand Potential Zoonoses

Cited by 16 publications

References 41 publications

RETRACTED: Canine Morbillivirus from Colombian Lineage Exhibits In Silico and In Vitro Potential to Infect Human Cells

RETRACTED: Canine Morbillivirus from Colombian Lineage Exhibits In Silico and In Vitro Potential to Infect Human Cells

A concise review on certain important veterinary viruses in the Americas

Canine Distemper Virus in Wild Carnivore Populations from the Czech Republic (2012–2020): Occurrence, Geographical Distribution, and Phylogenetic Analysis

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