Maintaining food quality is a priority due to it is the basis of products acceptability from the consumer. In this regard, the lifetime of full-cream pasteurized milk stored under refrigeration at different temperatures (7, 15, 20 and 28 C) was calculated using computer-aided tools, applying the chemical kinetics of casein degradation and a mathematical model based on the Arrhenius equation. During a period of time, pH values were monitored until sample rejection was corroborated by a sensory panel. The information collected allowed calculating kinetic parameters (k, EA, Q10 and pre-exponential factor) by lineal regression using Statgraphics Centurion XV. Monitoring pH and casein concentration variables through time showed a negative impact on the quality and durability of full-cream pasteurized milk as the temperature was increased. It was found that both models give an appropriate approach to predict the lifetime of full-cream pasteurized milk, with an average variation of16.2 % at 7, 15 and 28°C. In this sense, at 4 °C pasteurized whole milk has a lifetime of 13.83 days.