Origin of Macrophages

Ginsel, L.A.

doi:10.1007/978-1-4757-9534-9_3

Cited by 4 publications

(2 citation statements)

References 94 publications

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“…Our results give additional data about the morphological and functional heterogenity of macrophages described previously (van Furth et aI., 1972;van Furth, 1988;Ginsel, 1993). The heterogenity may be due to 1.)…”

Section: Discussionsupporting

confidence: 81%

Early endocytotic steps in elicited macrophages: omega‐shaped plasma membrane vesicles at their cell surface.

Kiss

1995

Cell Biology International

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Fluid-phase and receptor-mediated endocytosis were studied in Freund's adjuvant elicited macrophages. These cells were found to bind and internalize significantly larger amounts of peroxidase-antiperoxidase (PAP) immune complex than resident macrophages. Similarly the rate of the fluid-phase uptake was higher in elicited cells. When studying the early steps of endocytotic processes, omega-shaped plasma membrane pits (d approximately 90 nm) were found at the macrophage cell surface. Although occurring occasionally in resident cells, their number was highly increased after elicitation in 30% of the macrophage cell population. The different morphology of these cells coincided with a lower endocytotic activity and a very strong ecto Ca(2+)-ATPase reaction. The present findings indicate that the elicited macrophage population is heterogenous and consists of different subclasses.

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Section: Discussionsupporting

confidence: 81%

Early endocytotic steps in elicited macrophages: omega‐shaped plasma membrane vesicles at their cell surface.

Kiss

1995

Cell Biology International

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“…Despite these variations, most macrophages can be defined by the expression of certain enzymes, such as lysozyme and peroxidase [23]. In addition to phagocytosis of infectious materials, macrophages also function during host tissue repair, regulation of inflammatory events (through secretion of cytokines), regulation of immune responses (through antigen presentation to lymphocytes) and are believed to influence certain aspects of neovascularization [23,25,26]. …”

Section: Introductionmentioning

confidence: 99%

The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish

et al. 2007

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Background: How different immune cell compartments contribute to a successful immune response is central to fully understanding the mechanisms behind normal processes such as tissue repair and the pathology of inflammatory diseases. However, the ability to observe and characterize such interactions, in real-time, within a living vertebrate has proved elusive. Recently, the zebrafish has been exploited to model aspects of human disease and to study specific immune cell compartments using fluorescent reporter transgenic lines. A number of blood-specific lines have provided a means to exploit the exquisite optical clarity that this vertebrate system offers and provide a level of insight into dynamic inflammatory processes previously unavailable.

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Amphibia Kupffer cells

Sichel

Scalia

Corsaro

2002

Microscopy Res & Technique

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Amphibia Kupffer cells (i.e., liver resident macrophages) show many common characteristics when compared with Mammalia Kupffer cells: filopodia, microvillous-like structures, lamellipodia, fuzzy coat, coated vesicles, bristled vacuoles, nonspecific esterase activity, and pinocytotic and phagocytic activity are present both in Amphibia and Mammalia Kupffer cells. On the other hand, some differences are present between Kupffer cells of both zoological classes: phagocytosed red cells and their derivatives, iron-protein complexes, and lipofuscin bodies are normally present in Amphibia Kupffer cells, but absent in the same cells of healthy mammals. Worm-like structures are not seen in Amphibia and endogenous peroxidase activity is very weak in these animals compared with Mammalia. The most important difference lies in the ability of Amphibia Kupffer cells to produce melanins: in fact the tyrosinase gene is expressed, "melanosome centers" are present, and dopa oxidase activity is demonstrable.

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Origin of Macrophages

Cited by 4 publications

References 94 publications

Early endocytotic steps in elicited macrophages: omega‐shaped plasma membrane vesicles at their cell surface.

Early endocytotic steps in elicited macrophages: omega‐shaped plasma membrane vesicles at their cell surface.

The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish

Amphibia Kupffer cells

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