Origin of mink cytopathic focus-forming (MCF) viruses:Comparison with ecotropic and xenotropic murine leukemia virus genomes

Chattopadhyay, Sisir K.; Lander, Marilyn R.; Gupta, Sukumar; Rands, Elaine; Lowy, Douglas R.

doi:10.1016/0042-6822(81)90175-6

Cited by 188 publications

(163 citation statements)

References 36 publications

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“…(ii) The mink cell focus-forming (MCF) class of recombinant MLVs has been proposed as intermediates in the induction of lymphomas by MLVs (22,23). The restriction endonuclease cleavage map of the proviruses found adjacent to c-myc is inconsistent with their being MCF recombinants of MoMLV, but rather is consistent with their being intact, unaltered MLV proviruses (24,25). In fact, none of the five proviruses present in the RT 10-2 lymphoma is an MCF-type provirus (unpublished data).…”

Section: Methodsmentioning

confidence: 85%

Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas.

Steffen¹

1984

Proc. Natl. Acad. Sci. U.S.A.

160

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Sixty-one murine leukemia virus-induced lymphomas were examined for evidence of proviral insertions adjacent to known oncogenes. Five of these lymphomas were found to have alterations adjacent to c-myc. Two of the lymphomas with altered c-myc sequences were examined in detail. Evidence was obtained showing that the alterations in the cmyc sequences in these two lymphomas were the result of proviral integrations. This result suggests that lymphomagenesis by murine leukemia viruses can result from insertional mutagenesis of cellular oncogenes.

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Section: Methodsmentioning

confidence: 85%

Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas.

Steffen¹

1984

Proc. Natl. Acad. Sci. U.S.A.

160

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“…Laboratory mice are a mosaic of the wild mouse species of house mice, and 3 of the 4 house mouse species (M. molossinus, M. castaneus, M. musculus) carry X-MLV-related sequences and are capable of producing infectious virus (4,17,26,43,46,47). It is therefore possible that the Bxv1 provirus originated in one of these wild mouse species.…”

Section: Inbred Strain Distribution Of the Inducible Xmv Locus Bxv1mentioning

confidence: 99%

Common Inbred Strains of the Laboratory Mouse That Are Susceptible to Infection by Mouse Xenotropic Gammaretroviruses and the Human-Derived Retrovirus XMRV

Baliji

Liu

Kozak

2010

J Virol

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Laboratory mouse strains carry endogenous copies of the xenotropic mouse leukemia viruses (X-MLVs), named for their inability to infect cells of the laboratory mouse. This resistance to exogenous infection is due to a nonpermissive variant of the XPR1 gammaretrovirus receptor, a resistance that also limits in vivo expression of germ line X-MLV proviruses capable of producing infectious virus. Because laboratory mice vary widely in their proviral contents and in their virus expression patterns, we screened inbred strains for sequence and functional variants of the XPR1 receptor. We also typed inbred strains and wild mouse species for an endogenous provirus, Bxv1, that is capable of producing infectious X-MLV and that also contributes to the generation of pathogenic recombinant MLVs. We identified the active Bxv1 provirus in many common inbred strains and in some Japanese Mus molossinus mice but in none of the other wild mouse species that carry X-MLVs. Our screening for Xpr1 variants identified the permissive Xpr1 sxv allele in 7 strains of laboratory mice, including a Bxv1-positive strain, F/St, which is characterized by lifelong X-MLV viremia. Cells from three strains carrying Xpr1 sxv , namely, SWR, SJL, and SIM.R, were shown to be infectable by X-MLV and XMRV; these strains carry different alleles at Fv1 and vary in their sensitivities to specific X/P-MLV isolates and XMRV. Several strains with Xpr1 sxv lack the active Bxv1 provirus or other endogenous X-MLVs and may provide a useful model system to evaluate the in vivo spread of these gammaretroviruses and their disease potential in their natural host.

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“…Considerable recent evidence indicates that genetic recombination between the env genes of ecotropic-and xenotropic-related murine leukemia virus (MuLV) is essential for acquisition of viral determinants of leukemogenicity in mice (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Ap-parently inconsistent with this concept are results with Gross passage A virus, originally derived from extracts of a spontaneous AKR mouse leukemia by serial passage in mice ofthe low leukemia incidence strain C3Hf/Bi (17).…”

mentioning

confidence: 99%

Leukemogenesis by Gross passage A murine leukemia virus: expression of viruses with recombinant env genes in transformed cells.

Famulari¹,

Koehne²,

O’Donnell³

1982

Proc. Natl. Acad. Sci. U.S.A.

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Gross passage A murine leukemia virus (MuLV) derived from extracts of C3Hf/Bi mouse leukemias has been shown to be a virus complex consisting of ecotropic, xenotropic, and recombinant, dualtropic MuLV components. The three virus components were distinguished biochemically by differences in the molecular weights and peptide maps oftheir primary env gene products synthesized in infected cells in vivo and in vitro. Virus expression was studied in primary leukemias induced in C3Hf/ Bi mice by Gross passage A virus extracts and by the individual ecotropic and recombinant MuLV components that were isolated in vitro. Our findings suggest that expression of the recombinant MuLV component of the Gross passage A virus complex is necessary and sufficient for the induction of leukemias in C3Hf/Bi mice. In contrast, induction of leukemias by the ecotropic virus component appears to involve generation of a second virus with characteristics of recombinant, dualtropic MuLV.

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Origin of mink cytopathic focus-forming (MCF) viruses:Comparison with ecotropic and xenotropic murine leukemia virus genomes

Cited by 188 publications

References 36 publications

Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas.

Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas.

Common Inbred Strains of the Laboratory Mouse That Are Susceptible to Infection by Mouse Xenotropic Gammaretroviruses and the Human-Derived Retrovirus XMRV

Leukemogenesis by Gross passage A murine leukemia virus: expression of viruses with recombinant env genes in transformed cells.

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