Origin of Ovarian Cancer: Molecular Profiling

Dutta, Dilip; Dutta, Indranil

doi:10.1007/s13224-013-0419-x

Cited by 19 publications

(18 citation statements)

References 22 publications

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“…Previously, it was hypothesized that tubal ligation is a significant protective factor in ovarian malignancies [9]. But the latest research [10] has made clear that tubal ligation protects only against Clear cell and Endometrioid ovarian cancers as they ''p'' = ns migrate from the endometrium, whereas the Serous cancers arise from the fimbrial end of the fallopian tube, and Mucinous and Brenner tumors originate from Walthard cell nests which are not protected by tubal ligation. As there are no cases of Clear cell and Endometrioid cancers in our study, exact correlation between tubal ligation and specific histological pattern Ovarian cancer is not possible.…”

Section: Discussionmentioning

confidence: 99%

Ovarian Masses: Changing Clinico Histopathological Trends

Sharadha

Sridevi

Renukadevi

et al. 2014

J Obstet Gynecol India

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Results Incidence of ovarian masses was 6.9 %. Among 205 cases, 68 % were neoplastic. Among the neoplasms, 87.8 % were benign, 10 % malignant, and 2.2 % borderline. Mean ages of malignant and benign neoplasm were 41 and 39 years, respectively. 42.9 % malignant tumors presented with non-specific abdominal and constitutional symptoms. Serous cystadenoma was the commonest benign tumor (67 %) followed by Mucinous (19 %) and Dermoid (11.6 %). Most common malignant ovarian tumor was Serous cystadenocarcinoma (42.9 %). Out of the malignant cases, all were primary except one secondary deposit from Non-Hodgkin's Lymphoma. Only 28.6 % presented at stage I, remaining presented at stage III/IV. Conclusion Ovarian neoplasms have twice the incidence of non-neoplasms. Mean age of malignant tumors is decreased. Rising trend in Mucinous cystadenoma is noted.

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Section: Discussionmentioning

confidence: 99%

Ovarian Masses: Changing Clinico Histopathological Trends

Sharadha

Sridevi

Renukadevi

et al. 2014

J Obstet Gynecol India

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“…Hence, it is applied in various industrial fields, including textile production, food processing, and agriculture. 4,5) Additionally, GlcNAc oligomers prepared from chitin have useful biological activities, including immunostimulation and the induction of plant defense responses. 6) Moreover, GlcNAc monomers can be used as sweeteners and nutritional supplements.…”

mentioning

confidence: 99%

Heterologous Expression and Functional Characterization of a Novel Chitinase from the Chitinolytic BacteriumChitiniphilus shinanonensis

Huang¹,

Shizume²,

Nogawa³

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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Chitiniphilus shinanonensis strain SAY3T is a chitinolytic bacterium isolated from moat water of Ueda Castle in Nagano Prefecture, Japan. Fifteen genes encoding putative chitinolytic enzymes (chiA-chiO) have been isolated from this bacterium. Five of these constitute a single operon (chiCDEFG). The open reading frames of chiC, chiD, chiE, and chiG show sequence similarity to family 18 chitinases, while chiF encodes a polypeptide with two chitin-binding domains but no catalytic domain. Each of the five genes was successfully expressed in Escherichia coli, and the resulting recombinant proteins were characterized. Four of the recombinant proteins (ChiC, ChiD, ChiE, and ChiG) exhibited endo-type chitinase activity toward chitinous substrates, while ChiF showed no chitinolytic activity. In contrast to most endo-type chitinases, which mainly produce a dimer of N-acetyl-D-glucosamine (GlcNAc) as final product, ChiG completely split the GlcNAc dimer into GlcNAc monomers, indicating that it is a novel chitinase.

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“…Figure 1 shows the chemical structures of these two compounds, chitin (R=C(O)CH 3 ) and chitosan (R=H). After cellulose, chitin is the most abundant naturally occurring polymer (4)(5)(6). It is composed of linear chains of poly(β-(1-4)-N-acetyl-D-glucosamine) and is present in crustacean shells as ordered crystalline microfibrils forming a complex structure with associated proteins, minerals and lipids.…”

Section: Introductionmentioning

confidence: 99%

Lactic acid demineralization of green crab (Carcinus maenas) shells: effect of reaction conditions and isolation of an unusual calcium complex

Greene

Robertson

Young

et al. 2016

Green Chemistry Letters and Reviews

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Chitin and chitosan are potentially useful and environmentally friendly biopolymers with a wide range of value-added applications. Effective and green technologies for isolation of these materials are potentially important. Here, we report the use of lactic acid for the demineralization of green crab shells. Green crab shells and lactic acid, produced during cheese making, are two waste streams that could be tapped for large-scale chitin and chitosan processing. We have studied the effect of concentration and temperature on the demineralization of green crab shells. An unusual calcium lactate/lactic acid complex was also isolated and crystallographically characterized. The results have implications not only for the use of weak acids in the isolation of chitin and chitosan but also for the use of lactic acid as a solvent in green chemistry. ARTICLE HISTORY

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Origin of Ovarian Cancer: Molecular Profiling

Cited by 19 publications

References 22 publications

Ovarian Masses: Changing Clinico Histopathological Trends

Ovarian Masses: Changing Clinico Histopathological Trends

Heterologous Expression and Functional Characterization of a Novel Chitinase from the Chitinolytic BacteriumChitiniphilus shinanonensis

Lactic acid demineralization of green crab (Carcinus maenas) shells: effect of reaction conditions and isolation of an unusual calcium complex

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