The Trans-Pecos region of Texas, in the southeasternmost part of the Basin and Range province, is semiarid; precipitation ranges from less than 250 to 450 millimeters and potential evapotranspiration is as great as 2.5 meters annually. Structurally, the region is transitional with the Great Plains to the east; only the northern and western parts of the region have well-developed, northwest-trending basins and ranges. The area has experienced repeated deformation since the Precambrian with igneous activity and basin-and-range extension, and to a lesser extent Laramide structures, dominating the topography. Potential host media for isolation of high-level radioactive waste in the region include: (1) Intrusive rocks occurring as stocks, sills, and laccoliths of several rock types; (2) tuffaceous rocks, which include densely welded ash-flow tuff; (3) basaltic lava flows; and (4) argillaceous Manuscript approved for publication, January 3, 1985. rocks. Quaternary tectonism of the region is characterized by: (1) Many small earthquakes and only one damaging earthquake; (2) heat flow that is transitional between that of the craton to the east and the greater heat flow of the Basin and Range; and (3) Quaternary fault scarps, which are more common in the western part of the region. Longterm (late Cenozoic to modern) vertical crustal movement is estimated to be 1 to 2 meters per 10,000 years. Surface and groundwater drainage in the region is to the Rio Grande and to topographically closed basins. Groundwater recharge in the upland areas and in channels of ephemeral streams probably averages about 10 millimeters or less annually. Relatively long travel paths and traveltimes exist from groundwater divides to natural discharge areas. Ground water generally contains less than 1,000 milligrams per liter of dissolved solids except in the Salt Basin where concentrations exceed 3,000 milligrams per liter. Mineral production from the Trans-Pecos region has been dominated by silver, fluorspar, and mercury. Bl B2