Origin of Urinary Resorcinol Sulphate

Decarboxylation and demethylation of some phenolic benzoic acid derivatives by rat caecal contents

“…This variation has also been seen in in vivo experiments where a conjugate of resorcinol was found in the urine of some but not all rats given gallic acid orally (Scheline, 1966). A similar finding in man has been reported by Curzon (1957) and Curzon & Pratt (1964) who found that resorcinol sulphate was excreted by some subjects. They suggested that it originated from the action of particular intestinal bacteria on dietary tea polyphenols.…”

In vitro colonic catabolism of orange juice (poly)phenols

“…Aromatic ketones such as acetophenone and propiophenone are metabolized by several animals to mandelic and phenylhydracrylic acid, respectively . Such a gut microflora transformation would utilize the C–C hydrolase enzyme produced by several gut microflora anaerobes and simultaneously generate an A‐ring derivative with a 2,4‐dihydroxy substitution, such as 2,4‐dihydroxybenzoic acid (β‐resorcylic acid) or resorcinol, which has been found in human urine as a resorcinol sulfate . Stoupi et al.…”

“…Aromatic ketones such as acetophenone and propiophenone are metabolized by several animals to mandelic and phenylhydracrylic acid, respectively [38]. Such a gut microflora transformation would utilize the C-C hydrolase enzyme produced by several gut microflora anaerobes [39] and simultaneously generate an A-ring derivative with a 2,4-dihydroxy substitution, such as 2,4-dihydroxybenzoic acid (␤-resorcylic acid) [40] or resorcinol, which has been found in human urine as a resorcinol sulfate [41]. Stoupi et al [42] detected an A-ring-derived 2,4-dihydroxyphenyl metabolite when procyanidin B2 was incubated with human gut microbiota, and there are reports of volunteers excreting 3-(3hydroxyphenyl)hydracrylic acid after consuming (+)-catechin [43], green tea [44], and mixed wine and grape juice [45,46].…”