Origin of ventricular reflexes caused by coronary arteriography.

Pérez-Gómez, Francisco; García-Aguado, A

doi:10.1136/hrt.39.9.967

Cited by 51 publications

(11 citation statements)

References 20 publications

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“…2 ' 3 Further, these observations suggest that cardiac receptors mediating vasodepressor effects are preferentially distributed to the inferior wall of the heart in man. 2 Myocardial necrosis in dogs 4 and coronary occlusion in cats 5 ' 6 are known to activate cardiac receptors and to induce reflex responses 7 …”

mentioning

confidence: 83%

Preferential distribution of inhibitory cardiac receptors with vagal afferents to the inferoposterior wall of the left ventricle activated during coronary occlusion in the dog.

Thames¹,

Klopfenstein²,

Abboud³

et al. 1978

Circulation Research

197

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The purpose of this study was to determine the relative magnitudes of the reflex effects mediated by cardiac receptors during anterior as opposed to inferoposterior ischemia of the left ventricle of the dog. Cessation of perfusion (coronary "occlusion") of the circumflex coronary artery (Cx) in 29 chloralose-anesthetized dogs with common carotids ligated (group I) resulted in significant bradycardia and hypotension, but in no significant change in perfusion pressure in the gracilis muscle perfused at constant flow. Occlusion of the left anterior descending coronary artery (LAD) produced less hypotension, no change in heart rate, and vasoconstriction in the gracilis. After vagotomy and aortic nerve section, no significant change in heart rate or gracilis perfusion pressure was observed during lad or Cx occlusion, and the blood pressure responses to LAD and Cx occlusion were not different. In nine dogs with sinoaortic denervation (group II), brief Cx occlusion resulted in bradycardia, hypotension, and vasodilation in the gracilis muscle. LAD occlusion in group II dogs caused less hypotension and no change in heart rate or gracilis perfusion pressure. After vagotomy, the bradycardia and vasodilation resulting from Cx occlusion were abolished and the blood pressure responses to LAD and Cx occlusion were not different. The weights of left ventricle perfused by each occluded vessel were not different. These data show that left ventricular receptors with vagal afferents which are activated during coronary occlusion and which mediate cardioinhibitory and vasodepressor responses are located mainly in the inferoposterior left ventricle of the dog heart.

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mentioning

confidence: 83%

Preferential distribution of inhibitory cardiac receptors with vagal afferents to the inferoposterior wall of the left ventricle activated during coronary occlusion in the dog.

Thames¹,

Klopfenstein²,

Abboud³

et al. 1978

Circulation Research

197

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show abstract

“…Clinical and experimental data have shown that the Bezold-Jarisch reflex plays an important role in the control of cardiovascular function in normal and pathophysiological conditions (41)(42)(43). An indication of the functional role of this reflex in cardiovascular regulation was reported by Chianca Jr. and Machado (44), demonstrating an increased sensitivity of the Bezold-Jarisch reflex in both acute and chronic sinoaortic denervated rats (Figure 3).…”

Section: Cardiopulmonary Reflexesmentioning

confidence: 73%

Neural reflex regulation of arterial pressure in pathophysiological conditions: interplay among the baroreflex, the cardiopulmonary reflexes and the chemoreflex

Vasquez¹,

Meyrelles²,

Mauad³

et al. 1997

Braz J Med Biol Res

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The maintenance of arterial pressure at levels adequate to perfuse the tissues is a basic requirement for the constancy of the internal environment and survival. The objective of the present review was to provide information about the basic reflex mechanisms that are responsible for the moment-to-moment regulation of the cardiovascular system. We demonstrate that this control is largely provided by the action of arterial and non-arterial reflexes that detect and correct changes in arterial pressure (baroreflex), blood volume or chemical composition (mechanoand chemosensitive cardiopulmonary reflexes), and changes in bloodgas composition (chemoreceptor reflex). The importance of the integration of these cardiovascular reflexes is well understood and it is clear that processing mainly occurs in the nucleus tractus solitarii, although the mechanism is poorly understood. There are several indications that the interactions of baroreflex, chemoreflex and Bezold-Jarisch reflex inputs, and the central nervous system control the activity of autonomic preganglionic neurons through parallel afferent and efferent pathways to achieve cardiovascular homeostasis. It is surprising that so little appears in the literature about the integration of these neural reflexes in cardiovascular function. Thus, our purpose was to review the interplay between peripheral neural reflex mechanisms of arterial blood pressure and blood volume regulation in physiological and pathophysiological states. Special emphasis is placed on the experimental model of arterial hypertension induced by N-nitro-L-arginine methyl ester (L-NAME) in which the interplay of these three reflexes is demonstrable.

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“…On the other hand, when spontaneous angina was accompanied by a decrease in heart rate and systemic arterial pressure, ST segment changes were observed in inferior and inferolateral leads (table I). These two types of cardiovascular response frequently occur within 30-60 min after the onset of myocar dial infarction [10] and during coronary an giography [11] or coronary spasm [12], Time intervals during spontaneous an gina were differently affected in these two groups of patients. The number of patients included in each group is relatively small, since criteria of spontaneous angina in the invasive laboratory are difficult to meet; however, we believe that the results are fairly convincing, since changes during and after angina are quite consistent.…”

Section: Discussionmentioning

confidence: 99%

Electromechanical Events during Spontaneous Angina

et al. 1988

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The electromechanical events occurring during acute myocardial ischemia were assessed in 10 patients who developed spontaneous angina during cardiac catheterization. Aortic pressure and electrocardiogram were recorded, and heart rate and systolic and diastolic time intervals were measured under control conditions, at the onset of angina and during the relief of chest pain. In 5 patients spontaneous angina was accompanied by an increase in heart rate and systemic arterial pressure and by ST segment changes in anterior or anterolateral precordial leads. Diastolic time, expressed as percent of cardiac cycle, shortened from 48.8 ± 3.6% at rest to 33.6 ± 4.8% (p < 0.01) at the onset of angina, as a consequence of a significant increase in both electromechanical systole and heart rate, and returned to control values within 10 min after sublingual nitroglycerin. In the remaining 5 patients, spontaneous angina was accompanied by a decrease in heart rate and systemic arterial pressure and by ST segment changes in the inferior or inferolateral leads. The diastolic time increased significantly (p < 0.05) from 39.4 ± 6.1 % at rest to 47.8 ± 9% at the onset of angina, as a consequence of a significant decrease in heart rate and a slight decrease in electromechanical systole. Since coronary perfusion takes place mainly during diastole, our results suggest that the reflex increase in adrenergic tone may worsen myocardial ischemia by affecting diastolic perfusion time. In contrast, the increase in vagal tone may contribute to spontaneous relief of angina by prolonging diastolic perfusion time.

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Origin of ventricular reflexes caused by coronary arteriography.

Cited by 51 publications

References 20 publications

Preferential distribution of inhibitory cardiac receptors with vagal afferents to the inferoposterior wall of the left ventricle activated during coronary occlusion in the dog.

Preferential distribution of inhibitory cardiac receptors with vagal afferents to the inferoposterior wall of the left ventricle activated during coronary occlusion in the dog.

Neural reflex regulation of arterial pressure in pathophysiological conditions: interplay among the baroreflex, the cardiopulmonary reflexes and the chemoreflex

Electromechanical Events during Spontaneous Angina

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