Original article Disturbed regulation of the isolated middle cerebral artery in acute hyponatremia

Aleksandrowicz, Marta; Koźniewska, Ewa

doi:10.5114/fn.2013.37707

Cited by 7 publications

(7 citation statements)

References 37 publications

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“…Despite the importance of blood vessels function for the homeostasis of the brain, little is known about the influence of hyponatremia on cerebrovascular regulation 7. One previous study demonstrated that the dilatation of the cerebral vessel in response to acetylcholine, which is endothelium and nitric oxide dependent, was severely impaired in hyponatremia 8. Cerebral hypoxia due to vasoconstriction probably makes impairment of brain adaptation due to dysfunction of Na+ − K+ − ATPase, which is primary importance for the extrusion of ions from the glial cell 9.…”

Section: Discussionmentioning

confidence: 99%

Posterior Reversible Encephalopathy Syndrome Due to Hyponatremia

Jeon¹,

Park²,

Seo³

2014

J Epilepsy Res

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Posterior reversible encephalopathy syndrome (PRES) is characterized by variable associations of seizure activity, consciousness impairment, headaches, visual abnormalities, nausea/vomiting, and focal neurological signs. The PRES may occur in diverse situations. The findings on neuroimaging in PRES are often symmetric and predominate edema in the white matter of the brain areas perfused by the posterior brain circulation, which is reversible when the underlying cause is treated. We report the case of PRES in normotensive patient with hyponatremia. (2014;4:31-33)

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Section: Discussionmentioning

confidence: 99%

Posterior Reversible Encephalopathy Syndrome Due to Hyponatremia

Jeon¹,

Park²,

Seo³

2014

J Epilepsy Res

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“…Our previous studies indicate that acute hyponatremia, which was induced in vitro without the presence of vasopressin, did not affect autoregulation, but blunted the response of the MCA to ACh, NO donor, and acidosis [ 4 , 5 ]. Acute hyponatremia also decreased the sensitivity of the BK Ca channels in vascular smooth muscle cells to agonists [ 4 ], which would explain the impaired response of the MCA to the abovementioned vasodilators.…”

Section: Discussionmentioning

confidence: 99%

Effect of vasopressin-induced chronic hyponatremia on the regulation of the middle cerebral artery of the rat

Aleksandrowicz

Koźniewska

2018

Pflugers Arch - Eur J Physiol

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Vasopressin (arginine vasopressin, AVP) plays a crucial role in maintaining body fluid homeostasis. Excessive release of vasopressin can lead to hyponatremia. Changes in cerebral circulation during vasopressin-induced chronic hyponatremia are not elucidated. The present study has been designed to investigate the effect of chronic vasopressin-induced hyponatremia on the regulation of the tone of the middle cerebral artery (MCA) of the rat. Chronic hyponatremia was induced in vivo with the help of vasopressin, released continuously from subcutaneously implanted ALZET mini-osmotic pumps, and a liquid diet. After 3.5 days of chronic hyponatremia, the plasma Na+ concentration decreased to 119 ± 3 mM. MCAs were isolated and placed in a MOPS-buffered saline solution containing 121 mM Na+. Chronic hyponatremia did not affect the response of the MCA to increased intravascular pressure, to the administration of acetylcholine (ACh) and nitric oxide (NO) donor (SNAP, S-nitroso-N-acetyl-DL-penicillamine), and to increased K+ concentration, but impaired the response of the MCA to increased extravascular H+ concentration. Disturbed response of the MCA to acidosis was associated neither with the impairment of KATP channels nor with the activation of vasopressin V1 receptor. Correction of hyponatremia did not restore the response of the MCA to acidosis. These results indicate that cerebral blood vessels do not fully adapt to prolonged vasopressin-induced hyponatremia.

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“…RAS activation can also lead to plaque rupture in atherosclerotic lesions, along with with cardiac and brain damage [19,20]. Third, a study has shown that hyponatremia impairs NOdependent vasodilatation in cerebral artery [21]. Dysregulation of perfusion in cerebral vessels is possibly related to occurrence of ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%

Increased Risk of Ischemic Stroke in Patients with Chronic Kidney Disease after Recurrent Dysnatremias: A Nationwide Population-Based Cohort Study

Chung¹,

Yu²,

Wu³

et al. 2018

Neuropsychiatry

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Dysnatremias are the common problems in chronic kidney disease (CKD) patients and associated with neurologic symptoms. Thus, the purpose of this study was to determine the association between dysnatremias (either hypernatremia or hyponatremia) and risk of stroke in CKD population. A retrospective cohort study was constructed using the claims data of the entire insured residents covered by Taiwan's universal health insurance from 2000 to 2011. Severe hyponatremia and hypernatremia are defined as the need of 3% sodium chloride treatment and the need of admission respectively. A total of 365 hyponatremia and 137 hypernatremia patients and 1983 matched comparisons were recruited. The incidence of stroke was defined using the International Classification of Diseases, 9th Revision, Clinical Modification. Cox proportional hazard regression and Kaplan-Meier curves were used for the analyses. In the analysis, CKD with dysnatremias were with more diabetes, heart failure, mental illness, liver cirrhosis, cancer history and diuretics treatment. Compared with comparisons, patients with dysnatremias, hyponatremia or hypernatremia patients had a 2.57 (95% CI: 1.91-3.46), 2.35 (95% CI: 1.67-3.29) and 3.35 (95% CI: 2.04-5.50) fold risks of stroke after adjusting for potential factors. There was similarly increased risk for ischemic stroke, but not for hemorrhagic stroke. In addition, patients with recurrent dysnatremias, the risk of stroke much increased ) for hyponatremia and 11.4 (95% CI: 5.66-23.1) for hypernatremia]. In conclusion, we suggest more intensive surveillance to prevent recurrent dysnatremias and ischemic stroke should be emphasized.

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Original article Disturbed regulation of the isolated middle cerebral artery in acute hyponatremia

Cited by 7 publications

References 37 publications

Posterior Reversible Encephalopathy Syndrome Due to Hyponatremia

Posterior Reversible Encephalopathy Syndrome Due to Hyponatremia

Effect of vasopressin-induced chronic hyponatremia on the regulation of the middle cerebral artery of the rat

Increased Risk of Ischemic Stroke in Patients with Chronic Kidney Disease after Recurrent Dysnatremias: A Nationwide Population-Based Cohort Study

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