ORIGINAL ARTICLE Effect of Ketotifen Fumarate, Olopatadine, and Levocabastine on Ocular Active Anaphylaxis in the Guinea Pig and Ocular Immediate Hypersensitivity in the Albino Rat

Schoch, Christian

doi:10.1080/09273940590909167

Cited by 10 publications

(4 citation statements)

References 11 publications

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“…However, ketotifen is a compound with strong anti-anaphylactic and antihistaminic properties both in experimental animals and humans [19]. Ketotifen not only blocks H 1 receptors and stabilizes mast cells, it also reduces intracellular calcium levels in activated mast cells [20,21]. In the present study, we did not note an effect of Buk music on mast cell stabilization and intracellular calcium level.…”

Section: Discussioncontrasting

confidence: 51%

The Sound of a Buk (Korean Traditional Drum) Attenuates Anaphylactic Reactions by the Activation of Estrogen Receptor-β

Kim

Nam

et al. 2015

Int Arch Allergy Immunol

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Background: Anaphylaxis is associated with systemic vasodilation that causes low blood pressure and induces hypoxic brain damage. The sound of a Buk (Korean traditional drum) is similar to the human heart beat and affects blood pressure, heart rate, and the nervous system by increasing physiological excitation and sympathetic nervous system activity. So, this study focused on the effect of Buk music as a means of treating anaphylaxis. Methods: Mice were given an intraperitoneal injection of compound 48/80 (6.5 mg/kg, a mast cell degranulator). After compound 48/80 injection, mice were exposed to Buk music and white noise for 5 min in a sound isolation booth. The mortality rate was checked over the next 40 min. Levels of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in the serum and brain tissues were analyzed by Western blotting, quantitative real-time PCR, and ELISA methods. Results: Exposure to Buk music significantly reduced compound 48/80-induced mortality and histamine release, as well as HIF-1α and VEGF levels compared with the compound 48/80 group or compound 48/80 and white noise group. Buk music also reduced levels of tumor necrosis factor-α, and significantly increased estrogen receptor-β mRNA levels. Conclusion: These results indicate that Buk music has potential for the treatment of anaphylaxis.

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Section: Discussioncontrasting

confidence: 51%

The Sound of a Buk (Korean Traditional Drum) Attenuates Anaphylactic Reactions by the Activation of Estrogen Receptor-β

Kim

Nam

et al. 2015

Int Arch Allergy Immunol

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“…28 To determine the effect of anti-allergic agents on the conjunctival vasculature, 16 mg/kg of EB (30 mg/mL in sterile saline) was then injected into the cervical vein immediately prior to challenge. 29…”

Section: Methodsmentioning

confidence: 99%

Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: Preparation, characterization, and in vivo evaluation

Chen

Zhou

et al. 2011

J Biomater Appl

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The purpose of this study was to evaluate the feasibility of in situ thermosensitive hydrogel based on chitosan in combination with disodium α-d-Glucose 1-phosphate (DGP) for ocular drug delivery system. Aqueous solution of chitosan/DGP underwent sol-gel transition as temperature increased which was flowing sol at room temperature and then turned into non-flowing hydrogel at physiological temperature. The properties of gels were characterized regarding gelation time, gelation temperature, and morphology. The sol-to-gel phase transition behaviors were affected by the concentrations of chitosan, DGP and the model drug levocetirizine dihydrochloride (LD). The developed hydrogel presented a characteristic of a rapid release at the initial period followed by a sustained release and remarkably enhanced the cornea penetration of LD. The results of ocular irritation demonstrated the excellent ocular tolerance of the hydrogel. The ocular residence time for the hydrogel was significantly prolonged compared with eye drops. The drug-loaded hydrogel produced more effective anti-allergic conjunctivitis effects compared with LD aqueous solution. These results showed that the chitosan/DGP thermosensitive hydrogel could be used as an ideal ocular drug delivery system in terms of the suitable sol-gel transition temperature, mild pH environment in the hydrogel as well as the organic solvent free.

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“…Although cyclosporine A is reported to inhibit degranulation of mast cells in vitro, 12,13 the effect of cyclosporine A on the early-phase reaction is not well studied in vivo. We therefore examined the effect of cyclosporine A eye drops in the early-phase reaction such as plasma exudation and mast cell degranulation in the conjunctiva 30 min after RW challenge in actively sensitized to that shown in Figure 1B because administration of cyclosporine A eye drops 3 h before RW challenge signifi cantly decreased the increase in vascular permeability.…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that anti-histamine is a potent inhibitor of the early-phase reaction. 12,14 Ketotifen instillation showed the most potent inhibitory effect on plasma exudation after single RW challenge. mice.…”

Section: Effect Of Cyclosporine a Eye Drops On The Itch-scratch Respomentioning

confidence: 91%

Cyclosporine A Eye Drops Inhibit the Early-Phase Reaction in a Type-I Allergic Conjunctivitis Model in Mice

Shii

Oda

Shinomiya

et al. 2009

Journal of Ocular Pharmacology and Therapeutics

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ORIGINAL ARTICLE Effect of Ketotifen Fumarate, Olopatadine, and Levocabastine on Ocular Active Anaphylaxis in the Guinea Pig and Ocular Immediate Hypersensitivity in the Albino Rat

Cited by 10 publications

References 11 publications

The Sound of a Buk (Korean Traditional Drum) Attenuates Anaphylactic Reactions by the Activation of Estrogen Receptor-β

The Sound of a Buk (Korean Traditional Drum) Attenuates Anaphylactic Reactions by the Activation of Estrogen Receptor-β

Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: Preparation, characterization, and in vivo evaluation

Cyclosporine A Eye Drops Inhibit the Early-Phase Reaction in a Type-I Allergic Conjunctivitis Model in Mice

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