Original article Evaluation of oxidative and nitrosative stress in relapsing remitting multiple sclerosis: effect of corticosteroid therapy

Seven, Aru; Aslan, Mine; İncir, Said; Altıntaş, Ayşe

doi:10.5114/fn.2013.34197

Cited by 34 publications

(28 citation statements)

References 27 publications

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“…Most patients finally suffer from a smouldering, chronic inflammatory, progressive MS process in the long term. Concomitantly, an upregulated free-radical synthesis may occur in the central nervous system [Ljubisavljevic et al 2013;Mitosek-Szewczyk et al 2010] that may be influenced by steroids [Seven et al 2013]. Free radicals play a role in a variety of normal regulatory systems.…”

Section: Introductionmentioning

confidence: 99%

One-time intrathecal triamcinolone acetonide application alters the redox potential in cerebrospinal fluid of progressive multiple sclerosis patients: a pilot study

Müller

Herrling²,

Lütge

et al. 2016

Ther Adv Neurol Disord

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Introduction: Cerebrospinal fluid analysis may provide insight into the interplay between chronic inflammation and response to treatment. Objectives: To demonstrate the impact of one intrathecal triamcinolone injection on the redox potential and on ascorbyl radical appearance in the cerebrospinal fluid of chronic progressive multiple sclerosis patients. Methods: A total of 16 patients received 40 mg triamcinolone. Electron-spin resonance spectroscopy measured the oxidation range after copper ion [Cu (II)] addition and ascorbylradical bioavailability. Results: There was an increase of Cu (II) ion absorption, which reflects an augmented content of reduced proteins. Ascorbyl radicals were present in contrast to healthy controls according to the literature. Conclusion: Intrathecal steroid application alters the redox potential in cerebrospinal fluid. Our findings support the beneficial role of steroids on oxidative stress generally demonstrated by ascorbyl radical appearance. Reactive oxygen species decline is necessary for an upregulated production of reduced proteins.

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Section: Introductionmentioning

confidence: 99%

One-time intrathecal triamcinolone acetonide application alters the redox potential in cerebrospinal fluid of progressive multiple sclerosis patients: a pilot study

Müller

Herrling²,

Lütge

et al. 2016

Ther Adv Neurol Disord

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“…A single study also reported significantly higher 3-NT in an SPMS group compared to RRMS [81]. Conversely, Seven et al [27] reported reduced 3-NT immediately following relapse and following corticosteroid treatment (p<0.001). Case mix differences may partly explain this discrepancy as the latter is the only study in this section in which all MS subjects had RRMS and were enrolled after an acute relapse.…”

Section: Protein Nitrosylationmentioning

confidence: 88%

“…Three studies described no significant difference but were heterogeneous as to the MS disease phenotype, and none considered patients following an acute relapse [24][25][26]. A single study [27] found the opposite: significantly lower mean tNOx in RRMS patients compared to control groups; no significant study characteristics were identified to explain this disparity. tNOx has been considered across RRMS and SPMS groups with mixed resultsone study reported significantly higher mean tNOx in RRMS than SPMS [22] whereas others reported no significant difference [16,17,23].…”

Section: Peripheral Bloodmentioning

confidence: 89%

Oxidative Stress-Related Biomarkers in Multiple Sclerosis: A Review

et al. 2016

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms AbstractObjective: To provide an up to date review of oxidative stress biomarkers in multiple sclerosis and thus identify candidate molecules with greatest promise as biomarkers of diagnosis, disease activity or prognosis.Method: A semi-systematic literature search using PubMed and other databases.Results: Nitric oxide metabolites, superoxide dismutase, catalase, glutathione reductase, inducible nitric oxide synthase, protein carbonyl, 3-nitrotyrosine, isoprostanes, malondialdehyde and products of DNA oxidation have been identified across multiple studies as having promise as diagnostic, therapeutic or prognostic markers in MS.Conclusion: Heterogeneity of study design, particularly patient selection, limits comparability across studies. Further cohort studies are needed, and we would recommend promising markers be incorporated into future clinical trials to prospectively validate their potential.

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“…Systemic methylprednisolone administration has been shown to induce rat lens opacity (19) . The protective effect of methylprednisolone against oxidative injury has been found in several disease types (20)(21)(22)(23)(24) . However, no studies in the literature have related the impact of systemic methylprednisolone to the oxidative stress of crystalline lenses.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress of crystalline lens in rat menopausal model

Acer¹,

Pekel²,

Küçükatay³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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Purpose: To evaluate lenticular oxidative stress in rat menopausal models. Methods: Forty Wistar female albino rats were included in this study. A total of thirty rats underwent oophorectomy to generate a menopausal model. Ten rats that did not undergo oophorectomy formed the control group (Group 1). From the rats that underwent oophorectomy, 10 formed the menopause control group (Group 2), 10 were administered a daily injection of methylprednisolone until the end of the study (Group 3), and the remaining 10 rats were administered intraperitoneal streptozocin to induce diabetes mellitus (Group 4). Total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) measurements of the crystalline lenses were analyzed. Results: The mean OSI was the lowest in group 1 and highest in group 4. Nevertheless, the difference between the groups was not statistically significant in terms of OSI (p>0.05). The mean TOS values were similar between the groups (p>0.05), whereas the mean TAC of group 1 was significantly higher than that of the other groups (p<0.001). Conclusions:Our results indicate that menopause may not promote cataract formation.

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Original article Evaluation of oxidative and nitrosative stress in relapsing remitting multiple sclerosis: effect of corticosteroid therapy

Cited by 34 publications

References 27 publications

One-time intrathecal triamcinolone acetonide application alters the redox potential in cerebrospinal fluid of progressive multiple sclerosis patients: a pilot study

One-time intrathecal triamcinolone acetonide application alters the redox potential in cerebrospinal fluid of progressive multiple sclerosis patients: a pilot study

Oxidative Stress-Related Biomarkers in Multiple Sclerosis: A Review

Oxidative stress of crystalline lens in rat menopausal model

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