Original article Involvement of D 2 /D 2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate

Razavi, Samira; Haeri-Rohani, Ali; Eidi, Akram; Zarrindast, Mohammad Reza

doi:10.5114/fn.2014.43788

Cited by 5 publications

(3 citation statements)

References 98 publications

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“…We postulate that novelty-induced rearing may represent risk-taking or impulsivity. The KOR-stimulated increase in avoidance behavior is consistent with prior observations of its aversive effects in the caudal NAc shell [8] and has previously been associated with reduced dopamine release and activity in the NAc shell [39,40]. Finally, while locomotor activity is commonly thought to involve the NAc core rather than shell, a reduction of dopamine with application of 7-OH-DPAT in the NAc shell has been shown to decrease locomotor activity [41].…”

Section: Discussionsupporting

confidence: 85%

Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis

et al. 2020

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Neural circuit engagement within the nucleus accumbens (NAc) shell is implicated in the regulation of both negative and positive affect. Classically, the dynorphin/kappa opioid receptor (KOR) system in the NAc was believed to promote dysphoric behavior, while dopamine was viewed as interacting with reward behavior, and KOR activation was known to inhibit dopamine release. Recently, however, both the KOR and dopamine systems have, separately, been shown to have differential effects across the rostro-caudal axis of the NAc shell on hedonic responses. Whether or not this is due to interactions between KORs and dopamine, and if it extends to other affective behaviors, remains to be determined. In this study, we examined in rats the relationship between the KOR and dopamine systems in both the rostral and caudal NAc shell using ex vivo fast scan cyclic voltammetry and the impact of KOR activation on affective behavior using approach-avoidance assays. We report here that activation of KORs in the caudal NAc shell significantly inhibits dopamine release, stimulates novelty-induced rearing behavior, increases avoidance behavior, and reduces locomotor activity. In contrast, activation of KORs in the rostral NAc shell inhibits dopamine release to a lesser extent and instead increases approach behavior. Taken together, these results indicate that there is heterogeneity across the rostro-caudal axis of the NAc shell in the effects of KOR stimulation on affective behaviors, and they suggest that this might be due to differences in KOR control over dopamine release.

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Section: Discussionsupporting

confidence: 85%

Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis

et al. 2020

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“…Thus, we hypothesize that the novelty-induced rearing may represent increased risk-taking or impulsivity. Increased anxiety-like behavior, as measured in an elevated plus maze, has been associated with reduced dopamine release and activity in the NAc shell (Avena et al, 2008;Razavi et al, 2014), and the ability of the KOR to induce anxiety-like or avoidance behavior in the present study is in line with prior observations of its aversive effects in the caudal NAc shell (Castro & Berridge, 2014). Finally, while the effect of dopamine on locomotor activity is commonly thought to involve the NAc core, a reduction of dopamine with application of 7-OH-DPAT in the NAc shell has also been found to decrease locomotor activity (Clements & Greenshaw, 2005).…”

Section: Discussionmentioning

confidence: 99%

Kappa-opioid receptor-dependent changes in dopamine and affective behavior occur differentially across the nucleus accumbens shell rostro-caudal axis

Pirino

Spodnick

Gargiulo

et al. 2020

Preprint

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Neural activity in the nucleus accumbens (NAc) shell has long been implicated in the regulation of negative and positive affect. Classically, the dynorphin/kappa opioid receptor (KOR) system in the NAc was believed to promote dysphoric behaviors, while dopamine release was viewed as interacting with reinforcing stimuli, and KOR-activation was known to inhibit dopamine release. Recently, however, both the KOR and dopamine systems have been shown to have differential effects across the rostro-caudal axis of the NAc shell on hedonic responses. Whether or not this is due to interactions between KORs and dopamine, and if it extends to other affective behaviors, remains to be determined. In this study, we examined in rats the relationship between the KOR and dopamine systems in both the rostral and caudal NAc shell using ex vivo fast scan cyclic voltammetry and the impact of KOR activation on affective behaviors using various assays.We found that activation of KORs in the caudal NAc shell resulted in greater dopamine inhibition, and stimulated novelty-induced rearing behavior and anxiety-like and avoidance behaviors while reducing locomotor activity. In contrast, activation of KORs in the rostral NAc shell resulted in less dopamine inhibition and actually reduced anxiety-like and avoidance behaviors. These results demonstrate that there is heterogeneity across the rostro-caudal axis of the NAc shell in the effects of KOR stimulation on affective behavior and they suggest that this might be due to differences in KOR control over dopamine inhibition.

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“…As the amygdala is known to mediate memories with emotional content (Herry et al, 2010 ; Lüthi and Lüscher, 2014 ) and to project extensively to the AcbShm (Heimer et al, 1997 ), it is plausible that amygdala-AcbShm projections modulate the effect of anxiety on AcbShm MSN activation. Regions medial of the nucleus accumbens i.e., the major island of Calleja and intermediate part of the lateral septum as well as the medial septum/diagonal band complex have also been shown to be affected by rewarding/reinforcing effects of drugs of abuse (Mahler and Aston-Jones, 2012 ; Prast et al, 2014 ) or by anxiety (Menard and Dallas, 1996 ; Degroot and Treit, 2003 ; Razavi et al, 2014 ). For instance, it has been shown that neurons in the lateral septum were specifically activated during cue-induced cocaine seeking (Mahler and Aston-Jones, 2012 ) or that the cocaine CPP reacquisition-induced EGR1 expression was increased in the medial septum/diagonal band complex and also in the major islands of Calleja and the intermediate part of the lateral septum (Prast et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Increased conditioned place preference for cocaine in high anxiety related behavior (HAB) mice is associated with an increased activation in the accumbens corridor

Prast

Schardl

Sartori

et al. 2014

Front. Behav. Neurosci.

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Anxiety disorders and substance use disorders are strongly associated in humans. Accordingly, a widely held but controversial concept in the addiction field, the so-called “self-medication hypothesis,” posits that anxious individuals are more vulnerable for drug dependence because they use drugs of abuse to alleviate their anxiety. We tested this hypothesis under controlled experimental conditions by quantifying the conditioned place preference (CPP) to 15 mg/kg i.p. cocaine given contingently (COCAINE) in CD1 mice selectively bred for high anxiety-related behavior (HAB) vs. normal anxiety-related behavior (NAB). Cocaine was conditioned to the initially non-preferred compartment in an alternate day design (cocaine vs. saline, four pairings each). HAB and NAB mice were also tested for the effects of non-contingent (NONCONT) cocaine administration. HAB mice showed a slightly higher bias for one of the conditioning compartments during the pretest than NAB mice that became statistically significant (p = 0.045) only after pooling COCAINE and NONCONT groups. Cocaine CPP was higher (p = 0.0035) in HAB compared to NAB mice. The increased cocaine CPP was associated with an increased expression of the immediate early genes (IEGs) c-Fos and Early Growth Related Protein 1 (EGR1) in the accumbens corridor, i.e., a region stretching from the anterior commissure to the interhemispheric border and comprising the medial nucleus accumbens core and shell, the major island of Calleja and intermediate part of the lateral septum, as well as the vertical limb of the diagonal band and medial septum. The cocaine CPP-induced EGR1 expression was only observed in D1- and D2-medium spiny neurons, whereas other types of neurons or glial cells were not involved. With respect to the activation by contingent vs. non-contingent cocaine EGR1 seemed to be a more sensitive marker than c-Fos. Our findings suggest that cocaine may be more rewarding in high anxiety individuals, plausibly due to an anxiolytic effect.

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Original article Involvement of D 2 /D 2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate

Abstract: A b s t r a c t Glutamatergic system stimulation in some parts of the brain may affect anxiety-related behaviours

Cited by 5 publications

References 98 publications

Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis

Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis

Kappa-opioid receptor-dependent changes in dopamine and affective behavior occur differentially across the nucleus accumbens shell rostro-caudal axis

Increased conditioned place preference for cocaine in high anxiety related behavior (HAB) mice is associated with an increased activation in the accumbens corridor

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