ORIGINAL ARTICLE: Role of Inflammatory Cytokines and eNOS Gene Polymorphism in Pathophysiology of Pre‐Eclampsia

Abstract

An IL-6-mediated endothelium dependent NO-cyclic guanine monophosphate-mediated relaxation pathway may be inhibited in systemic vessels in pre-eclampsia. As observed in this study Glu298Asp eNOS gene polymorphism did not showed significant association with pre-eclampsia.

Association of common eNOS/NOS3 polymorphisms with preeclampsia in Tunisian Arabs

“…Several polymorphisms in NOS3 gene were identified, of which three common functional polymorphisms were studied. These comprise the promoter -786T>C (rs2070744) single-nucleotide polymorphism (SNP) (Aggarwal et al, 2010;Lizbeth et al, 2011;Sandrim et al, 2010), the 4b/4a (rs61722009) variable number of 27 bp-repeat tandem repeats in intron 4 ( Rahimi et al, 2013;Sandrim et al, 2010;Singh et al, 2010), and the functional Glu298Asp (rs1799983) exon 7 variant, G to T substitution at nucleotide position 894 resulting in the replacement of glutamic acid with aspartic acid at codon 298 the Glu298Asp (Rahimi et al, 2013;Turan et al, 2010;Yu et al, 2006). However, conflicting and controversial results were reported among different studies.…”

“…Guo et al, 1999;Singh et al, 2010;Turan et al, 2010). Insofar as plasma NO levels are dependent on environmental and genetic factors, it was shown that-786T>C, Glu289Asp and 4b/4a NOS3 variants can alter the secretion and function ofNO (Deng et al, 2010; Zdoukopoulos et al, 2011).…”

MTHFR C677T and eNOS G894T variants in preeclamptic women: Contribution to lipid peroxidation and oxidative stress

“…However, subsequent studies from various populations did not support a role for this polymorphism in the pathogenesis of preeclampsia. The studies of Hakli et al [17] from eastern Finland, Yoshimura et al [18] from Bangladesh, Landau et al [19] among Hispanic and white women, Singh et al [20] from India and Yu et al [21] from England did not detect an association between this polymorphism and the risk of preeclampsia. Also, in the study by Sandrim et al [22] no association was detected between two eNOS polymorphisms (G894T and T786C) and the risk of preeclampsia.…”

“…The role of endothelial nitric oxide synthase (eNOS) polymorphism in the pathogenesis of preeclampsia is debated [14][15][16][17][18][19][20][21][22][23][24].…”

Association between functional polymorphisms in the nitric oxide synthase 3 gene and pediatric acute respiratory distress syndrome

“…Several polymorphisms in NOS3 were identified in this study, among which, three common functional polymorphisms, the promoter -786T>C (rs2070744) SNP (Aggarwal et al, 2010), the 4b/4a (rs61722009) variable number of tandem repeats (27-bp repeat) in intron 4 (Singh et al, 2010;Rahimi et al, 2013), and the functional Glu298Asp (rs1799983) exon 7 variant (a G-to-T substitution at position 894 resulting in the replacement of glutamic acid with aspartic acid at codon 298) (Yu et al, 2006;Turan et al, 2010), were investigated. Recent clinical trials have proven the beneficiary effects of inhaled NO on respiratory syndromes (Schreiber et al, 2003;Ballard et al, 2006).…”