Original paper Can the histological type of colorectal cancer determine the carcinogenesis pathway?

Kołos, Małgorzata; Wasążnik-Jędras, Anna; Nasierowska‐Guttmejer, Anna

doi:10.5114/pjp.2015.53003

Cited by 8 publications

(8 citation statements)

References 11 publications

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“…Its etiology involves modifiable, medical and hereditary risk factors, and the precise events vary from one individual to another [4]. Various pathways of neoplastic progression contribute to the molecular and biological heterogeneity exhibited by CRCs [5]. About 85% of CRCs are sporadic and progress slowly by accumulating multiple genetic mutations (APC, KRAS, p53, and DCC) in precancerous lesions (polyps/adenomas).…”

Section: Introductionmentioning

confidence: 99%

Mucins and associated glycan signatures in colon adenoma–carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer

et al. 2016

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Development of biomarkers that detect early stage resectable premalignant lesions of colon can provide critical aid in prevention of colorectal cancer. Recent evidences advocate the utility of mucin expression to predict malignant transformation of colon pre-neoplastic lesions. In this study, we investigated the combined expression of multiple mucins and mucin-associated glycans during the adenoma-carcinoma sequence of colon cancer progression. Further, we evaluated their applicability as markers for differentiating adenomas/adenocarcinomas from hyperplastic polyps. Immunohistochemical analyses performed on colon disease tissue microarrays revealed that MUC2, MUC4 expression were downregulated (p<0.0001) and MUC1, MUC5AC expression were upregulated (p=0.01) during adenoma-adenocarcinoma progression. Expression of MUC17 was downregulated in inflamed tissues compared to normal tissues, but its increased expression differentiated adenomas (p=0.0028) and adenocarcinomas (p=0.025) from inflammation. MUC1 specific glycan-Tn/STn-MUC1 showed higher expression in hyperplastic polyps (p=0.023), adenomas (p=0.042) and adenocarcinomas (p=0.0096) compared to normal. Multivariate regression analyses indicated that a combination of MUC2, MUC5AC, and MUC17 could effectively discriminate adenoma-adenocarcinoma from hyperplastic polyps. Altogether, a combined analysis of altered mucins and mucin-associated glycans is a useful approach to distinguish premalignant/malignant lesions of colon from benign polyps.

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Section: Introductionmentioning

confidence: 99%

Mucins and associated glycan signatures in colon adenoma–carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer

et al. 2016

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“…TCCs can occur anywhere along the urinary tract, among which 90% are localized in the bladder, and approximately 90% of colorectal cancers are adenocarcinomas [1,8]. In the present case, TCC of the ascending colon was initially considered to be a metastatic lesion from a urologic or gynecologic carcinoma.…”

Section: Discussionmentioning

confidence: 94%

Clinically diagnosed primary transitional cell carcinoma of the colon: A case report

Taketomi

Ujiie

Enomoto

et al. 2019

International Journal of Surgery Case Reports

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“…In fact, a cocktail of varied histopathological types illustrates many pathways involved and simultaneously acquired additional molecular hits. Setting aside CRC heterogeneity’s meaning, Kolos et al [ 15 ] reported the loss of MSH-2 with a 2% frequency within left-sided typical CRCs, which should be taken into consideration in unequivocal discrimination of left- and right side CRC based only on a morphological pattern.…”

Section: Discussionmentioning

confidence: 99%

Conventional colon adenomas harbor various disturbances in microsatellite stability and contain micro-serrated foci with microsatellite instability

et al. 2017

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IntroductionColorectal cancer belongs to the most frequent occurring malignancies. A prediction of the clinical outcome and appropriate choice of neoadjuvant chemotherapy needs personalized insight to the main driving pathways. Because most CRCs have polyps as progenitor lesions, studying the pathways driving to adenomagenesis is no less important.GoalsOur purpose was the evaluation of microsatellite stability status within conventional colon adenomas and also β-catenin, BRAFV600E and p53 contribution.Material and methodsThe cohort included 101 cases of typical colon adenomas with high grade epithelial dysplasia according to WHO. An immunohistochemistry method was used for the depiction of the expression of targeted proteins, as also their heterogeneity.ResultsGenerally, we noted a 10% frequency of MSI events where MSI-H reached a 5% share occurred within the left colon and rectal polyps. β-catenin nuclear overexpression was noted with a 70% frequency and p53 with close to a 24% frequency. In addition, we found a presence of micro-serration foci more often within tubular adenomas, where focal MSI took place more often. Our results indicate that MSI events occur more often than had been theorized earlier. It results in tumour heterogeneity, more complex underlying pathways and finally ontogenetic molecular-diversity of tumours besides similar occurring histopathological features.

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Original paper Can the histological type of colorectal cancer determine the carcinogenesis pathway?

Cited by 8 publications

References 11 publications

Mucins and associated glycan signatures in colon adenoma–carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer

Mucins and associated glycan signatures in colon adenoma–carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer

Clinically diagnosed primary transitional cell carcinoma of the colon: A case report

Conventional colon adenomas harbor various disturbances in microsatellite stability and contain micro-serrated foci with microsatellite instability

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