Original Research Article Novel Nano-Sized Iron Complex Application Using Folate Based Imaging Agent

Abstract

Design and evaluation of new chemically nano composites towards molecular imaging of malignant tumors is being considered as a kind of medical global research interests. In the current experiment novel nano-composite based on gadolinium ions and anionic linear globular Dendrimer G2 (as biocompatible biodegradable hybrid nanomaterial grafted to folic acid was developed and biophysically assayed. The results showed a very good Magnetic Resonance (MR) relaxivity data on T2 decreasing as well as a very good cellular uptake and tolerance. The complex was found toxic with employing apoptosis as main mechanism of action on cancerous cells respectively. Based on results it could be concluded that such nano-complex may be used as novel theranostic agent in further in vivo practices in near future.