Original research article on cystic ovarian lesions diagnosed as teratomas - a 2 year study in a tertiary care hospital

Nagamuthu, Ezhil Arasi; Mudavath, Padmavathy; Kishore, Naval; Fatima, Syeda Sumaiya; Samudrala, Swapna

doi:10.18203/2320-6012.ijrms20162949

Cited by 3 publications

(2 citation statements)

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“…Abdominal pain may arise because of torsion, hemorrhage, infection, and pressure effects. [ 11 ] Abdominal pain was the most frequent clinical complaint (68.51%), which might happened due to pressure effects of ovarian masses owing to their size and cystic components. The presence of fertility and infertility is difficult to access in ovarian mature teratoma but infertility may result because of recurrent endometriosis.…”

Section: Discussionmentioning

confidence: 99%

Types and Frequency of Neural Elements in Mature Ovarian Teratomas

Dayal

Kumar

Krishna

2022

Journal of Microscopy and Ultrastructure

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Introduction: Teratomas are those tumors which are derived from the totipotent cells. They may manifest at any site. Ovary is the most common site for teratomas. Ovarian teratomas may be immature and mature depending on the elements they harbor. Mature ovarian teratomas may contain ectoderm, endoderm, and mesoderm. Ectoderm mainly comprises the skin and its adnexa, followed by neural tissue, whereas mesodermal elements are blood vessels, adipose tissue, cartilage, and hematopoietic tissue, similarly, endoderm consists of respiratory tissue, thyroid gland, and gastrointestinal tissue. Materials and Methods: This study was conducted in the histopathology section from January 2008 to April 2019 and included 54 cases of mature ovarian teratomas. The slides of ovarian tumors were evaluated, and the relationship between clinical and pathological findings was studied with emphasis predominantly on neural elements. Results: The most common age group among the women with ovarian teratoma was 21–30 (31.48%) years, the youngest patients been 8 years, and oldest of 60 years. The chief complaints were pain in 37 (68.51%), followed by mass per abdomen 25 (46.29%). On gross examination, most of the tumors were unilateral 53 (98.14%), having tufts of hairs with sebaceous material 34 (61.81%). Microscopic examination confirmed the presence of squamous epithelium and its adnexal structure 52 (94.54%). Neural elements were seen in 14 (25.45%) cases. In every case with neural elements, skin, its adnexa, and adipose tissue were also seen. Conclusion: Teratomas have diversity in the age of presentation, gross findings, and microscopy features. Neural elements are commonly found in 25.45% of ovarian teratoma which is mostly found in association with skin and adipose tissue. The combination of neural elements with adipose tissue signifies an association between them because both arise from different dermal elements.

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Section: Discussionmentioning

confidence: 99%

Types and Frequency of Neural Elements in Mature Ovarian Teratomas

Dayal

Kumar

Krishna

2022

Journal of Microscopy and Ultrastructure

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“…[4]. Although there are several studies of MCT in Asian countries, there are only very few retrospective cross sectional studies from India to understand the epidemiology of the disease [5]. Since the prognosis for malignant transformation of MCT is very poor with a five year survival of only 15-30%, it is essential to diagnose and treat them early in the course of disease [6].…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological Evaluation of 223 Cases of Mature Cystic Teratoma, Ovary: 25-Year Experience in a Single Tertiary Care Centre in India

Rathore

Sharma

Arora

2017

JCDR

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IntROduCtIOnThe term 'Teratoma' is derived from a greek word "teraton" which means monster. It was named so because these tumours contain elements derived from all the 3 germ cell layers of the ovary. MCT are the most common germ cell tumours of the ovary accounting for 10-20% of all the ovarian tumours. They comprise approximately one third of all the benign ovarian neoplasms and are most common ovarian tumour in patients between 20 to 40 years of age [1]. Torsion, rupture and infection are more common complications of MCT [2,3] and only very rarely do these tumours undergo a malignant transformation. The possibility of such malignant transformation must be kept in mind when either the patient is over 45 years of age or the tumour diameter is more than 10 cm. [4]. Although there are several studies of MCT in Asian countries, there are only very few retrospective cross sectional studies from India to understand the epidemiology of the disease [5]. Since the prognosis for malignant transformation of MCT is very poor with a five year survival of only 15-30%, it is essential to diagnose and treat them early in the course of disease [6]. We retrospectively analysed the clinicopathological characteristics and the trends of all the teratomas of the ovary at our institution over a 25-year study period. MAtERIALS And MEtHOdSThis was a retrospective study of all the teratomas of the ovary received in the Department of Pathology at a tertiary care hospital, India. It included a total of 242 cases of ovarian teratomas over a period of 25 years from 1990 to 2014. The data regarding age, size, laterality, gross, morphological features, complications and surgery performed was retrieved from the pathological archives and analysed using SPSS software version 22. Descriptive statistics was used and the results were expressed as percentages. RESuLtSA total of 1102 ovarian neoplasms were received in our department during a period of 25 years from 1990 to 2014. 25.7% (284/1102) of all the ovarian tumours so received in our department were Germ cell tumours. Of the consecutive 242 cases of ovarian teratoma 223 were MCT. These were the most common tumours in our study forming 20.2% of the total ovarian neoplasms and 78.5% of all the germ cell tumours. [Table/ Fig-1] represents the age wise distribution of various germ cell neoplasms found in our study. As is evident from the histogram, MCT was most common tumour in all the age groups. Apart from MCT there were 11 cases of immature teratoma and 8 cases of malignant teratoma each. The rate of malignant transformation of mature cystic teratoma was 3.5% in this study.The mean age of the patients with MCT was 32.5 ± 13.11 (mean ± standard deviation) years ranging from 8 years to 70 years. The median age was 30 years. [Table/ Fig-2] represents the age wise distribution of all the MCT included in our study. It was seen that maximum number of cases i.e., 39.4% were in the age group of 21-40 years and only 8% of patients presented beyond 50 years of age. It was noted that although the tumour ...

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Laparoscopic Management of Ovarian Dermoid Cyst in a 31-year-old Woman: A Case Report

Pramana¹

2021

World Journal of Laparoscopic Surgery With DVD

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Original research article on cystic ovarian lesions diagnosed as teratomas - a 2 year study in a tertiary care hospital

Cited by 3 publications

References 12 publications

Types and Frequency of Neural Elements in Mature Ovarian Teratomas

Types and Frequency of Neural Elements in Mature Ovarian Teratomas

Clinicopathological Evaluation of 223 Cases of Mature Cystic Teratoma, Ovary: 25-Year Experience in a Single Tertiary Care Centre in India

Laparoscopic Management of Ovarian Dermoid Cyst in a 31-year-old Woman: A Case Report

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